Anti-Aging Premium Clinic Kit

Epithalon is a synthetic tetrapeptide based on the natural epithalamin produced by the pineal gland. It activates telomerase (hTERT), the enzyme responsible for adding telomeric repeats to chromosome ends, thereby extending telomere length and increasing cellular replicative capacity. It also stimulates melatonin production from the pineal gland, restoring circadian rhythm function that declines with age. Additionally, it modulates antioxidant enzyme expression and has been shown to extend lifespan in animal models.

FOXO4-DRI is a retro-inverso peptide (D-amino acid mirror image in reverse sequence) designed to disrupt the interaction between FOXO4 and p53 in senescent cells. In cellular senescence, FOXO4 accumulates in the nucleus and sequesters p53, preventing p53-mediated apoptosis and keeping senescent cells alive. FOXO4-DRI competitively blocks this interaction, freeing p53 to trigger apoptosis selectively in senescent cells while sparing healthy cells. This makes it a targeted senolytic agent.

NAD+ is an essential coenzyme present in all living cells that serves as an electron carrier in metabolic redox reactions (glycolysis, TCA cycle, oxidative phosphorylation) and as a substrate for NAD+-consuming enzymes including sirtuins (SIRT1-7), PARPs, and CD38. Sirtuins are NAD+-dependent deacetylases that regulate DNA repair, mitochondrial biogenesis, inflammation, and stress resistance. NAD+ levels decline with age, and restoring NAD+ activates these protective pathways, enhancing cellular energy production, DNA repair capacity, and stress resilience.

MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. It activates AMPK, enhancing glucose uptake and fatty acid oxidation in skeletal muscle. MOTS-c regulates the folate cycle and de novo purine biosynthesis, leading to AICAR accumulation and subsequent AMPK activation. It translocates to the nucleus under metabolic stress to regulate adaptive gene expression, functioning as an exercise mimetic at the molecular level.

SS-31 is a cell-permeable, mitochondria-targeted tetrapeptide that concentrates ~1000-fold in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to this membrane. By stabilizing cardiolipin's interaction with cytochrome c, SS-31 optimizes electron transport chain efficiency, reduces electron leak, and decreases mitochondrial reactive oxygen species (ROS) production. It does not act as a traditional antioxidant scavenger but rather prevents ROS formation at the source by maintaining proper mitochondrial function.

Pinealon is a synthetic tripeptide bioregulator designed to target the pineal gland and central nervous system. It penetrates cell membranes and reaches the nucleus where it binds to specific DNA sequences to regulate gene expression related to neurotransmitter synthesis, antioxidant enzyme production, and neuroendocrine function. It promotes melatonin synthesis in pinealocytes, has neuroprotective properties against oxidative stress, and modulates neuronal apoptosis through regulation of anti-apoptotic gene expression.

Humanin is a mitochondrial-derived peptide encoded by the MT-RNR2 gene (16S ribosomal RNA). It exerts cytoprotective effects by binding to IGFBP-3 (blocking its pro-apoptotic effects), binding to BAX (preventing mitochondrial membrane permeabilization and apoptosis), and activating the STAT3 signaling pathway via the CNTFR/WSX-1/gp130 receptor complex. Humanin protects neurons from amyloid-beta toxicity and has broad anti-apoptotic, inflammatory-pathway, and metabolic regulatory functions.

GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. It functions as a signaling molecule that resets gene expression to a healthier state, upregulating genes involved in antioxidant defense, DNA repair, and tissue remodeling while downregulating inflammatory and tissue-destructive genes. It stimulates collagen synthesis, glycosaminoglycan production, and angiogenesis. The copper ion is essential for activating copper-dependent enzymes like lysyl oxidase (collagen cross-linking) and superoxide dismutase.