Humanin - Front - MiPeptidos
Anti-Aging / Longevity

Humanin

CAS: 330936-69-1

Humanin is a research peptide in the anti-aging / longevity category. Humanin is a mitochondrial-derived peptide encoded by the MT-RNR2 gene (16S ribosomal RNA). MiPeptidos offers Humanin in 1 sizes with 99.3% verified purity and full analytical documentation.

Starting at
$126.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How Humanin Works

Humanin is a mitochondrial-derived peptide encoded by the MT-RNR2 gene (16S ribosomal RNA). It exerts cytoprotective effects by binding to IGFBP-3 (blocking its pro-apoptotic effects), binding to BAX (preventing mitochondrial membrane permeabilization and apoptosis), and activating the STAT3 signaling pathway via the CNTFR/WSX-1/gp130 receptor complex. Humanin protects neurons from amyloid-beta toxicity and has broad anti-apoptotic, anti-inflammatory, and metabolic regulatory functions.

Research Applications

1
Alzheimer's disease and amyloid-beta neuroprotection
2
Mitochondrial-derived peptide biology
3
Anti-apoptotic signaling pathways
4
Age-related cognitive decline
5
Cardiovascular protection and metabolic regulation
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$126.95$926.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.3%purity
mAURetention Time (min)0250500750100005101520253099.3%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Humanin
PASSES ALL SPECIFICATIONS
Batch NumberHR-HMNN-2600215
Date of AnalysisMarch 11, 2026
Purity (HPLC)99.3%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)2687.28 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg Humanin + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Humanin product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Akiko Sato, PhD·Yokohama, Japan

Humanin from MiPeptidos is essential for our neuroprotection and anti-apoptotic research. The 24-amino-acid mitochondria-derived peptide showed cytoprotective effects in our amyloid-beta toxicity assays exactly as publis...

Feb 1, 2026
View All Reviews →

Frequently Asked Questions

Humanin (CAS: 330936-69-1) is a research compound, with a molecular weight of 2687.28 Da in the Anti-Aging / Longevity category. Humanin is a mitochondrial-derived peptide encoded by the MT-RNR2 gene (16S ribosomal RNA). It exerts cytoprotective effects by binding to IGFBP-3 (blocking its pro-apoptotic effects), binding to BAX (preventing mitochondrial membrane permeabilization and apoptosis), and activating the STAT3 signaling pathway via the CNTFR/WSX-1/gp130 receptor complex. Researchers commonly investigate Humanin for Alzheimer's disease and amyloid-beta neuroprotection, Mitochondrial-derived peptide biology, Anti-apoptotic signaling pathways. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your Humanin 10mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 2-3mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted Humanin at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
Humanin and MOTS-c are both mitochondrial-derived peptides (MDPs) encoded in the mitochondrial genome, but Humanin is a 24-amino acid cytoprotective peptide that signals through the STAT3 pathway via its trimeric receptor (CNTFR/WSX-1/gp130), while MOTS-c is a 16-amino acid metabolic regulator that activates AMPK. Humanin specifically protects against amyloid-beta toxicity and apoptosis, making it a focus of Alzheimer research. MiPeptidos offers both MDPs for mitochondrial biology studies.
Store lyophilized Humanin at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Humanin has a reported half-life of Short in plasma; intracellular effects persist longer, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Humanin order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-HMNN-2600215, tested March 11, 2026) shows 99.3% purity by HPLC, mass spectrometry confirmation at 2687.28 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
330936-69-1
Mol. Weight
2687.28 Da
Formula
C119H204N34O32S2
Half-Life
Short in plasma; intracellular effects persist longer
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg

Sequence

MAPRGFSCLLLLTSEIDLPVKRRA (24 amino acids; mitochondria-derived)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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