SS-31 - Front - MiPeptidos
Anti-Aging / Longevity

SS-31

CAS: 736992-21-5

SS-31 is a research peptide in the anti-aging / longevity category. SS-31 is a cell-permeable, mitochondria-targeted tetrapeptide that concentrates ~1000-fold in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to this membrane. MiPeptidos offers SS-31 in 2 sizes with 99.4% verified purity and full analytical documentation.

Starting at
$25.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How SS-31 Works

SS-31 is a cell-permeable, mitochondria-targeted tetrapeptide that concentrates ~1000-fold in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to this membrane. By stabilizing cardiolipin's interaction with cytochrome c, SS-31 optimizes electron transport chain efficiency, reduces electron leak, and decreases mitochondrial reactive oxygen species (ROS) production. It does not act as a traditional antioxidant scavenger but rather prevents ROS formation at the source by maintaining proper mitochondrial function.

Research Applications

1
Mitochondrial dysfunction and aging
2
Barth syndrome (FDA-approved indication)
3
Heart failure and cardiac ischemia-reperfusion
4
Acute kidney injury
5
Neurodegenerative diseases (mitochondrial component)
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$25.95$188.95
50mgBest Value
$98.95$721.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.4%purity
mAURetention Time (min)0250500750100005101520253099.4%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
SS-31
PASSES ALL SPECIFICATIONS
Batch NumberHR-SS31-2600315
Date of AnalysisFebruary 8, 2026
Purity (HPLC)99.4%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)639.80 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg SS-31 + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed SS-31 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

4.0/5from 1 review
Verified
Dr. Laura Bennett·New Haven, CT

SS-31 (elamipretide) targets the inner mitochondrial membrane and is vital for our cardiolipin interaction studies. Purity tested at 98.1% in our analysis. Four stars because this tetrapeptide is prone to oxidation and I...

Jan 19, 2026
View All Reviews →

Frequently Asked Questions

SS-31 (CAS: 736992-21-5) is a research compound, with a molecular weight of 639.80 Da in the Anti-Aging / Longevity category. SS-31 is a cell-permeable, mitochondria-targeted tetrapeptide that concentrates ~1000-fold in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to this membrane. By stabilizing cardiolipin's interaction with cytochrome c, SS-31 optimizes electron transport chain efficiency, reduces electron leak, and decreases mitochondrial reactive oxygen species (ROS) production. Researchers commonly investigate SS-31 for Mitochondrial dysfunction and aging, Barth syndrome (FDA-approved indication), Heart failure and cardiac ischemia-reperfusion. Every vial from MiPeptidos includes batch-specific analytical documentation.
SS-31 is available in 2 sizes (10mg, 50mg), so reconstitution volume depends on which vial you have. For the 10mg size, add 2-3mL of bacteriostatic water; for the 50mg size, use 5-6mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted SS-31 at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
SS-31 (Elamipretide) is a synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2, 640 Da) that penetrates to the inner mitochondrial membrane where it binds cardiolipin to stabilize electron transport chain complexes and reduce ROS production. MOTS-c works upstream on AMPK signaling rather than directly on mitochondrial structure. SS-31 is in clinical trials for Barth syndrome and heart failure. MiPeptidos carries both for complementary mitochondrial research approaches.
Store lyophilized SS-31 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, SS-31 has a reported half-life of ~4 hours (subcutaneous), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every SS-31 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-SS31-2600315, tested February 8, 2026) shows 99.4% purity by HPLC, mass spectrometry confirmation at 639.80 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
736992-21-5
Mol. Weight
639.80 Da
Formula
C32H49N9O5
Half-Life
~4 hours (subcutaneous)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg, 50mg

Sequence

D-Arg-Dmt-Lys-Phe-NH2 (tetrapeptide; Dmt = 2',6'-dimethyltyrosine)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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