MOTS-c - Front - MiPeptidos
Anti-Aging / Longevity

MOTS-c

CAS: 1627580-64-6

MOTS-c is a research peptide in the anti-aging / longevity category. MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. MiPeptidos offers MOTS-c in 4 sizes with 99.2% verified purity and full analytical documentation.

Starting at
$64.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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Batch Tracked

How MOTS-c Works

MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. It activates AMPK, enhancing glucose uptake and fatty acid oxidation in skeletal muscle. MOTS-c regulates the folate cycle and de novo purine biosynthesis, leading to AICAR accumulation and subsequent AMPK activation. It translocates to the nucleus under metabolic stress to regulate adaptive gene expression, functioning as an exercise mimetic at the molecular level.

Research Applications

1
Metabolic homeostasis and AMPK activation
2
Exercise mimetic and endurance research
3
Age-related metabolic decline
4
Insulin sensitivity and type 2 diabetes
5
Mitochondrial-nuclear communication (retrograde signaling)
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$64.95$473.95
15mg
$88.95$648.95
20mg
$113.95$831.95
40mgBest Value
$202.95$1481.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.2%purity
mAURetention Time (min)0250500750100005101520253099.2%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
MOTS-c
PASSES ALL SPECIFICATIONS
Batch NumberHR-MTSC-2600115
Date of AnalysisFebruary 26, 2026
Purity (HPLC)99.2%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)2174.60 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg MOTS-c + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed MOTS-c product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Ryan Cooper·Ann Arbor, MI

MOTS-c is a mitochondria-derived peptide critical for our metabolic regulation studies. MiPeptidos' 16-amino-acid peptide shows expected AMPK activation and improved glucose metabolism in our skeletal muscle cell models....

Nov 5, 2025
View All Reviews →

Frequently Asked Questions

MOTS-c (CAS: 1627580-64-6) is a research compound, with a molecular weight of 2174.60 Da in the Anti-Aging / Longevity category. MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. It activates AMPK, enhancing glucose uptake and fatty acid oxidation in skeletal muscle. Researchers commonly investigate MOTS-c for Metabolic homeostasis and AMPK activation, Exercise mimetic and endurance research, Age-related metabolic decline. Every vial from MiPeptidos includes batch-specific analytical documentation.
MOTS-c is available in 4 sizes (10mg, 15mg, 20mg, 40mg), so reconstitution volume depends on which vial you have. For the 10mg size, add 2-3mL of bacteriostatic water; for the 40mg size, use 5-6mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted MOTS-c at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
MOTS-c and SS-31 are both mitochondrial-derived peptides, but they work through entirely different pathways. MOTS-c is a 16-amino acid peptide encoded in mitochondrial DNA that activates AMPK and the folate-methionine cycle to regulate metabolic homeostasis. SS-31 (Elamipretide) is a tetrapeptide that binds cardiolipin in the inner mitochondrial membrane to stabilize electron transport chain function. MOTS-c is more of a metabolic regulator; SS-31 is a mitochondrial structure stabilizer. MiPeptidos stocks both.
Store lyophilized MOTS-c at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, MOTS-c has a reported half-life of Not fully characterized; biological effects last hours to days, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every MOTS-c order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-MTSC-2600115, tested February 26, 2026) shows 99.2% purity by HPLC, mass spectrometry confirmation at 2174.60 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
1627580-64-6
Mol. Weight
2174.60 Da
Formula
C101H152N28O22S2
Half-Life
Not fully characterized; biological effects last hours to days
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg, 15mg, 20mg, 40mg

Sequence

MRWQEMGYIFYPRKLR (16 amino acids; mitochondria-derived)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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