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MOTS-c - Front - MiPeptidos
Anti-Aging / Longevity

MOTS-c

CAS: 1627580-64-6

Metabolic homeostasis and AMPK activation · Exercise mimetic and endurance research · Age-related metabolic decline

MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus.

  • Metabolic homeostasis and AMPK activation
  • Exercise mimetic and endurance research
  • Age-related metabolic decline
  • Insulin sensitivity and glucose-regulation research
Research Use Only.

This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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≥99% HPLC| COA Included| Ships Today
≥99% Purity
COA Included
Third-Party Tested
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HPLC Purity Analysis

High-Performance Liquid Chromatography
99.2%purity
mAURetention Time (min)0250500750100005101520253099.2%
Method: RP-HPLC C18UV 220nmACN/H₂O + 0.1% TFA
CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
Same-Day Shipping
Batch Tracked

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS
1627580-64-6
Mol. Weight
2174.60 Da

How MOTS-c Works

MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. It activates AMPK, enhancing glucose uptake and fatty acid oxidation in skeletal muscle. MOTS-c regulates the folate cycle and de novo purine biosynthesis, leading to AICAR accumulation and subsequent AMPK activation. It translocates to the nucleus under metabolic stress to regulate adaptive gene expression, functioning as an exercise mimetic at the molecular level.

Research Applications

1
Metabolic homeostasis and AMPK activation
2
Exercise mimetic and endurance research
3
Age-related metabolic decline
4
Insulin sensitivity and glucose-regulation research
5
Mitochondrial-nuclear communication (retrograde signaling)

Pricing

SizePer Vial10-PackSavings
10mgSale
$54.95$70.00
$549.5021% off
15mg
$100.00$1000.00
20mgSale
$124.95$150.00
$1249.5017% off
40mgBest Value
$396.95$3969.50

10-pack pricing shown. Volume discounts for 50+ vials — contact us.

Certificate of Analysis

MiPeptidos
MOTS-c
PASSES ALL SPECIFICATIONS
Batch NumberHR-MTSC-2600115
Date of AnalysisFebruary 26, 2026
Purity (HPLC)99.2%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)2174.60 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.