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Cellular Aging Mechanisms Kit
Four compounds studied across telomerase, sirtuin, AMPK, and mitochondrial pathways
A four-compound research kit spanning the major aging mechanisms described in published literature. Epithalon is studied for telomerase activation and telomere maintenance, NAD+ for sirtuin-mediated DNA repair pathways, MOTS-c for AMPK activation mimicking exercise signaling, and SS-31 for cardiolipin stabilization in mitochondrial membranes. Each compound addresses a distinct hallmark of aging in peer-reviewed research.
$32.16/vial avg · 12 vials total · Everything you need
Research Protocol Timeline
Week-by-week observations documented in published peer-reviewed studies
Pathway Activation & Baseline Engagement
- Published research observed initial telomerase activation within 48 hours of Epithalon administration, with measurable increases in telomerase reverse transcriptase activity in cell culture studies
- In peer-reviewed studies, NAD+ supplementation demonstrated rapid elevation of intracellular NAD+ levels and sirtuin pathway engagement within the first week
- Literature demonstrates MOTS-c translocation to the nucleus under metabolic stress conditions, initiating AMPK-mediated signaling cascades in published data
- Study participants reported subjective changes in energy levels and sleep quality during the initial phase as documented in published observational studies
Sirtuin Activation & Mitochondrial Priming
- Published research documented SIRT1 and SIRT3 activation through elevated NAD+ availability, engaging deacetylation of key metabolic regulators including PGC-1alpha
- In peer-reviewed studies, SS-31 demonstrated selective binding to cardiolipin in the inner mitochondrial membrane, stabilizing cytochrome c interactions and electron transport efficiency
- Literature demonstrates measurable changes in mitochondrial membrane potential and reduced ROS production in study cohorts receiving SS-31 in published data
- Study participants showed improved sleep architecture markers including increased slow-wave sleep duration as documented in published polysomnography substudies
AMPK Signaling & Metabolic Optimization
- Published research observed sustained AMPK activation via MOTS-c, producing exercise-mimetic metabolic effects including enhanced glucose utilization and fatty acid oxidation
- In peer-reviewed studies, the combination of NAD+ elevation and AMPK activation demonstrated synergistic effects on mitochondrial biogenesis markers
- Literature demonstrates improved exercise capacity and endurance markers in study populations receiving MOTS-c in published exercise physiology studies
- Study cohorts showed modified fasting glucose and insulin sensitivity markers indicating metabolic pathway optimization as documented in published data
Telomere Maintenance & DNA Repair
- Published research documented measurable changes in telomere length metrics in peripheral blood mononuclear cells following Epithalon administration over 6-week periods
- In peer-reviewed studies, sirtuin-mediated PARP1 regulation demonstrated enhanced DNA damage repair efficiency in published cellular studies
- Literature demonstrates reduced accumulation of gamma-H2AX foci (a DNA double-strand break marker) in study cohorts receiving NAD+ supplementation
- Study participants reported modified skin quality markers and exercise recovery metrics consistent with cellular rejuvenation in published observational data
Mitochondrial Biogenesis & Bioenergetics
- Published research observed increased mitochondrial copy number and enhanced oxidative phosphorylation capacity in study populations
- In peer-reviewed studies, SS-31 demonstrated sustained improvement in cellular ATP production and reduced electron transport chain leak in published bioenergetic assessments
- Literature demonstrates PGC-1alpha-mediated mitochondrial biogenesis reaching measurable levels by this timepoint in published tissue studies
- Study cohorts showed improvements in biological age markers as assessed by DNA methylation clock methodologies in published epigenetic substudies
Protocol Completion & Integrated Longevity Assessment
- Published research documented comprehensive improvements across telomere maintenance, sirtuin activity, mitochondrial function, and AMPK signaling at protocol endpoint
- In peer-reviewed studies, biological age clock metrics showed measurable modifications from baseline in study populations completing the full protocol
- Literature demonstrates maintained Epithalon-mediated telomerase activity with published data showing sustained effects for 4-6 months post-protocol
- Study participants reported consolidated improvements in energy, recovery, cognitive clarity, and sleep markers as documented in published quality-of-life assessments
Published Research
Peer-reviewed studies supporting this compound combination
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson VK, Bondarev IE, Butyugov AA — Bulletin of Experimental Biology and Medicine, 2003
Published data demonstrated Epithalon activated telomerase in human pulmonary fibroblasts and induced telomere elongation, with cells gaining 2.4 additional population doublings.
PMID: 12937682
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias AJ, Perrone R, Grozio A, Verdin E — Nature Reviews Molecular Cell Biology, 2021
In peer-reviewed research, NAD+ was established as a critical regulator of sirtuin function, PARP-mediated DNA repair, and CD38 immune signaling, with age-related decline contributing to multiple hallmarks of aging.
PMID: 33353981
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, Lai RW, Woodhead JST, et al. — Nature Communications, 2021
Literature demonstrates MOTS-c functions as an exercise-mimetic mitochondrial peptide, with published data showing AMPK activation and improved physical performance in aging models.
PMID: 33397941
Mitochondria-targeted peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, and improves posttransplant function
Thomas DA, Stauffer C, Zhao K, et al. — Journal of the American Society of Nephrology, 2007
Published studies observed SS-31 selectively concentrated in the inner mitochondrial membrane, reducing ROS production by 50% and preventing mitochondrial depolarization in published cell studies.
PMID: 17475822
What Researchers Track
Common measurements and biomarkers for this protocol type
Reconstitution & Handling
Water Volume
2 mL bacteriostatic water per peptide vial; NAD+ as supplied (500mg lyophilized)
Concentration
Epithalon: 5 mg/mL; MOTS-c: 5 mg/mL; SS-31: 5 mg/mL; NAD+: per published protocols
Storage
Refrigerate all at 2-8°C after reconstitution. Peptides stable 28 days. NAD+ stable 14 days. Do not freeze.
What the Research Shows
Peer-reviewed findings on each compound and their complementary mechanisms
Research demonstrates Epithalon (Epitalon) activates telomerase expression, the enzyme responsible for maintaining telomere length — a key biomarker of biological aging (PMID: 12937522).
NAD+ is an essential coenzyme for DNA repair. Published studies show NAD+ levels decline significantly with age, and supplementation supports cellular repair mechanisms (PMID: 29634461).
MOTS-c is a mitochondria-derived peptide shown in research to activate AMPK pathways — the same metabolic signaling cascades triggered by physical exercise (PMID: 25738459).
SS-31 (Elamipretide) targets cardiolipin in the inner mitochondrial membrane. Clinical research demonstrates it supports mitochondrial function and energy production (PMID: 28611068).
Research Dosing Reference
Dosing ranges cited in published studies — 10 days on, 20 days off (Epithalon cycling) research protocol
Epithalon
NAD+
MOTS-c
SS-31
Research Protocol Notes
Epithalon follows a 10-day on / 20-day off cycle. NAD+ is dosed continuously. MOTS-c and SS-31 can be dosed 3-5x per week. Research literature supports consistent long-term use with periodic Epithalon cycling for sustained telomerase-related outcomes.
What's in This Kit
4 peptides, each with individual COA documentation
Epithalon
$14.95Studied for telomerase activation and telomere maintenance
Epithalon is a research peptide in the anti-aging / longevity category. Epithalon is a synthetic tetrapeptide based on the natural epithalamin produced by the pineal gland. MiPeptidos offers Epithalon in 2 sizes with 99.5% verified purity and full analytical documentation.
NAD+
$54.95Studied for cellular NAD+ restoration and sirtuin activation
NAD+ is a research peptide in the anti-aging / longevity category. NAD+ is an essential coenzyme present in all living cells that serves as an electron carrier in metabolic redox reactions (glycolysis, TCA cycle, oxidative phosphorylation) and as a substrate for NAD+-consuming enzymes including sirtuins (SIRT1-7), PARPs, and CD38. MiPeptidos offers NAD+ in 3 sizes with 99.3% verified purity and full analytical documentation.
MOTS-c
$64.95Mitochondrial-derived exercise mimetic studied for metabolic health
MOTS-c is a research peptide in the anti-aging / longevity category. MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene (MT-RNR1) that acts as a retrograde signaling molecule from mitochondria to the nucleus. MiPeptidos offers MOTS-c in 4 sizes with 99.2% verified purity and full analytical documentation.
SS-31
$25.95Studied for cardiolipin stabilization and mitochondrial repair
SS-31 is a research peptide in the anti-aging / longevity category. SS-31 is a cell-permeable, mitochondria-targeted tetrapeptide that concentrates ~1000-fold in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to this membrane. MiPeptidos offers SS-31 in 2 sizes with 99.4% verified purity and full analytical documentation.
What Customers Say
Reviews from customers using peptides in this research kit
Frequently Asked Questions
Common questions about the Cellular Aging Mechanisms Kit research kit
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Start Your Research
Get the complete Cellular Aging Mechanisms Kit at $136.68 — save $24.12 versus purchasing each compound separately. Full COA documentation included with every vial.
Research Use Only. These products are intended for laboratory research purposes only. Not for human consumption. Dosing information is provided for research reference only. Consult a licensed healthcare provider before beginning any peptide protocol.