Neuro & Cognitive Clinic Kit

Semax is a synthetic heptapeptide analog of ACTH(4-10) with a stabilizing Pro-Gly-Pro extension. It increases BDNF and TrkB receptor expression, enhances neurotrophic factor signaling, modulates dopaminergic and serotonergic neurotransmission, and provides neuroprotection through antioxidant and inflammatory-pathway mechanisms. Unlike ACTH, Semax has no steroidogenic activity. It improves cerebral circulation, enhances memory consolidation, and has been approved in Russia and Ukraine for stroke recovery and cognitive enhancement.

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension that enhances metabolic stability. It modulates the balance of Th1/Th2 cytokines, influences enkephalinase activity, and increases BDNF mRNA expression in the hippocampus. Selank produces anxiolytic effects comparable to benzodiazepines without sedation, cognitive impairment, or dependence by modulating GABAergic neurotransmission and monoamine metabolism in limbic structures.

Dihexa is a small, orally active, blood-brain barrier-permeable oligopeptide derivative of angiotensin IV. It acts as an allosteric agonist of the hepatocyte growth factor (HGF)/c-Met receptor system, potentiating HGF signaling at picomolar concentrations. This drives neurogenesis, synaptogenesis, and spinogenesis in the hippocampus. Dihexa is reportedly 10 million times more potent than BDNF in promoting neurite outgrowth. It also enhances synaptic plasticity and long-term potentiation, the cellular basis of learning and memory.

Pinealon is a synthetic tripeptide bioregulator designed to target the pineal gland and central nervous system. It penetrates cell membranes and reaches the nucleus where it binds to specific DNA sequences to regulate gene expression related to neurotransmitter synthesis, antioxidant enzyme production, and neuroendocrine function. It promotes melatonin synthesis in pinealocytes, has neuroprotective properties against oxidative stress, and modulates neuronal apoptosis through regulation of anti-apoptotic gene expression.

DSIP is a nonapeptide originally isolated from rabbit cerebral venous blood during electrically induced sleep. It promotes delta-wave (slow-wave) sleep by modulating neuroendocrine signaling, although its exact receptor has not been definitively identified. DSIP modulates corticotropin and cortisol levels, influences the hypothalamic-pituitary-adrenal axis, has analgesic properties through opioid system modulation, and exhibits antioxidant effects. It normalizes disrupted sleep architecture and has stress-protective effects on multiple organ systems.

Humanin is a mitochondrial-derived peptide encoded by the MT-RNR2 gene (16S ribosomal RNA). It exerts cytoprotective effects by binding to IGFBP-3 (blocking its pro-apoptotic effects), binding to BAX (preventing mitochondrial membrane permeabilization and apoptosis), and activating the STAT3 signaling pathway via the CNTFR/WSX-1/gp130 receptor complex. Humanin protects neurons from amyloid-beta toxicity and has broad anti-apoptotic, inflammatory-pathway, and metabolic regulatory functions.