Dihexa - Front - MiPeptidos
Cognitive / Neuropeptides

Dihexa

CAS: 1401708-83-5

Dihexa is a research peptide in the cognitive / neuropeptides category. Dihexa is a small, orally active, blood-brain barrier-permeable oligopeptide derivative of angiotensin IV. MiPeptidos offers Dihexa in 2 sizes with 99.6% verified purity and full analytical documentation.

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$28.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
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How Dihexa Works

Dihexa is a small, orally active, blood-brain barrier-permeable oligopeptide derivative of angiotensin IV. It acts as an allosteric agonist of the hepatocyte growth factor (HGF)/c-Met receptor system, potentiating HGF signaling at picomolar concentrations. This drives neurogenesis, synaptogenesis, and spinogenesis in the hippocampus. Dihexa is reportedly 10 million times more potent than BDNF in promoting neurite outgrowth. It also enhances synaptic plasticity and long-term potentiation, the cellular basis of learning and memory.

Research Applications

1
Cognitive enhancement (claimed as most potent nootropic)
2
HGF/c-Met receptor biology
3
Alzheimer's and dementia research
4
Synaptogenesis and neural connectivity
5
Blood-brain barrier permeable drug design
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$28.95$210.95
10mgBest Value
$45.95$334.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.6%purity
mAURetention Time (min)0250500750100005101520253099.6%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Dihexa
PASSES ALL SPECIFICATIONS
Batch NumberHR-DHX-2600115
Date of AnalysisJanuary 14, 2026
Purity (HPLC)99.6%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)504.66 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg Dihexa + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Dihexa product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. William Park·San Jose, CA

Dihexa is an extraordinary HGF receptor potentiator for our synaptogenesis research. MiPeptidos' hexapeptide analog of angiotensin IV showed potent pro-cognitive effects in our hippocampal slice models at picomolar conce...

Feb 24, 2026
View All Reviews →

Frequently Asked Questions

Dihexa (CAS: 1401708-83-5) is a research compound, with a molecular weight of 504.66 Da in the Cognitive / Neuropeptides category. Dihexa is a small, orally active, blood-brain barrier-permeable oligopeptide derivative of angiotensin IV. It acts as an allosteric agonist of the hepatocyte growth factor (HGF)/c-Met receptor system, potentiating HGF signaling at picomolar concentrations. Researchers commonly investigate Dihexa for Cognitive enhancement (claimed as most potent nootropic), HGF/c-Met receptor biology, Alzheimer's and dementia research. Every vial from MiPeptidos includes batch-specific analytical documentation.
Dihexa is available in 2 sizes (5mg, 10mg), so reconstitution volume depends on which vial you have. For the 5mg size, add 1-2mL of bacteriostatic water; for the 10mg size, use 2-3mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted Dihexa at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
Dihexa is extraordinarily potent — it enhances hepatocyte growth factor (HGF) signaling through the c-Met receptor at picomolar concentrations, making it approximately 10 million times more potent than BDNF for synaptogenesis. Semax works through ACTH-derived melanocortin/BDNF pathways at much higher concentrations. Dihexa (505 Da) is a small hexanedioic acid derivative, not a peptide in the traditional sense, and is studied for profound pro-cognitive effects. MiPeptidos offers both for different scales of neurotrophic research.
Store lyophilized Dihexa at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Dihexa has a reported half-life of Not fully characterized; orally active with sustained effects, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Dihexa order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-DHX-2600115, tested January 14, 2026) shows 99.6% purity by HPLC, mass spectrometry confirmation at 504.66 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
1401708-83-5
Mol. Weight
504.66 Da
Formula
C27H44N4O5
Half-Life
Not fully characterized; orally active with sustained effects
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg, 10mg

Sequence

N/A (peptidomimetic oligopeptide derived from angiotensin IV; not a standard amino acid sequence)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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