No spam. Unsubscribe anytime.
HPLC Purity Analysis
PNC-27
CAS: 1159861-00-3
Selective anticancer peptide therapy · HDM-2/MDM2 membrane biology in oncology · Tumor-selective membrane disruption
PNC-27 is a 32-amino acid chimeric anticancer peptide consisting of two functional domains: residues from the HDM-2 (human double minute 2) binding domain of p53 (PPLSQETFSDLWKLL), and a membrane residency peptide (MRP) from the Antennapedia homeodomain (KKWKMRRNQFWVKVQRG).
- Selective anticancer peptide therapy
- HDM-2/MDM2 membrane biology in oncology
- Tumor-selective membrane disruption
- p53 pathway and oncology cell death
This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.
Frequently Bought Together
Bacteriostatic Water
Required for reconstitution
AICAR
Specialty / Research
No spam. Unsubscribe anytime.
HPLC Purity Analysis
Specifications
How PNC-27 Works
PNC-27 is a 32-amino acid chimeric anticancer peptide consisting of two functional domains: residues from the HDM-2 (human double minute 2) binding domain of p53 (PPLSQETFSDLWKLL), and a membrane residency peptide (MRP) from the Antennapedia homeodomain (KKWKMRRNQFWVKVQRG). PNC-27 selectively binds to HDM-2 protein that is overexpressed in the plasma membrane of oncology cells (but not normal cells), causing membrane destabilization and rapid necrotic cell death. Normal cells, which express HDM-2 intranuclearly rather than on the cell surface, are unaffected.
Research Applications
Pricing
| Size | Per Vial | 10-Pack |
|---|---|---|
5mg | $80.00 | $800.00 |
10-pack pricing shown. Volume discounts for 50+ vials — contact us.
Certificate of Analysis
This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.
Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.
Related Peptides
AICAR
Exercise-mimetic compound studied for metabolic activation
ARA290 (Cibinetide)
Studied for neuroprotection via EPO-derived non-hematopoietic signaling
ACE 031
Studied for myostatin pathway inhibition in muscle research
ACTH 1-39
Studied for melanocortin-mediated stress response modulation