ACE 031 - Front - MiPeptidos
Specialty / Research

ACE 031

CAS: 1169766-01-1

ACE 031 is a research peptide in the specialty / research category. ACE-031 is a soluble decoy receptor consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to a human IgG1 Fc domain. MiPeptidos offers ACE 031 in 1 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$13.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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Batch Tracked

How ACE 031 Works

ACE-031 is a soluble decoy receptor consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to a human IgG1 Fc domain. It functions as a ligand trap, binding and neutralizing myostatin (GDF-8), activin A, GDF-11, and other TGF-beta superfamily ligands that negatively regulate muscle growth. By sequestering these ligands in the circulation, ACE-031 removes the natural brake on muscle growth, resulting in significant increases in muscle mass and strength. The Fc domain provides extended half-life through FcRn recycling.

Research Applications

1
Duchenne muscular dystrophy (clinical trials conducted)
2
Myostatin inhibition and muscle growth
3
Muscle wasting and sarcopenia
4
TGF-beta superfamily ligand trap biology
5
Bone mineral density enhancement (secondary effect)
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
1mg
$13.95$101.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
ACE 031
PASSES ALL SPECIFICATIONS
Batch NumberHR-C031-2600215
Date of AnalysisJanuary 1, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)~57,320 Da (fusion protein homodimer) — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
1.0 mL
1 mg ACE 031 + 1.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed ACE 031 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dmitri Petrov·Kiev, Ukraine

ACE-031 is a soluble activin receptor type IIB-Fc fusion protein we use for myostatin inhibition research. MiPeptidos' product shows expected myostatin sequestration in our muscle biology assays. The Fc-fusion is properl...

Jan 9, 2026
View All Reviews →

Frequently Asked Questions

ACE 031 (CAS: 1169766-01-1) is a research compound, with a molecular weight of ~57,320 Da (fusion protein homodimer) in the Specialty / Research category. ACE-031 is a soluble decoy receptor consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to a human IgG1 Fc domain. It functions as a ligand trap, binding and neutralizing myostatin (GDF-8), activin A, GDF-11, and other TGF-beta superfamily ligands that negatively regulate muscle growth. Researchers commonly investigate ACE 031 for Duchenne muscular dystrophy (clinical trials conducted), Myostatin inhibition and muscle growth, Muscle wasting and sarcopenia. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your ACE 031 1mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 1mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted ACE 031 at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
ACE-031 and FST-344 both inhibit myostatin, but through different architectures. ACE-031 is a soluble activin receptor type IIB-Fc fusion protein (~57,320 Da) that acts as a decoy receptor, trapping myostatin and other TGF-beta ligands before they reach cell surface receptors. FST-344 (Follistatin, ~38,000 Da) is a glycoprotein that directly binds and neutralizes myostatin. ACE-031 is broader — it also traps activin A and GDF-11. MiPeptidos stocks both for muscle biology research.
Store lyophilized ACE 031 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, ACE 031 has a reported half-life of ~10-15 days (Fc fusion provides extended circulation), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every ACE 031 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-C031-2600215, tested January 1, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at ~57,320 Da (fusion protein homodimer), endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
1169766-01-1
Mol. Weight
~57,320 Da (fusion protein homodimer)
Formula
Fusion protein (ActRIIB-IgG1-Fc)
Half-Life
~10-15 days (Fc fusion provides extended circulation)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
1mg

Sequence

Extracellular domain of human activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1; ~500+ amino acids per chain

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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