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AICAR - Front - MiPeptidos
Specialty / Research

AICAR

CAS: 2627-69-2

AMPK activation and energy metabolism · Exercise mimetic and endurance enhancement · Cardiac ischemia preconditioning

AICAR is a cell-permeable nucleoside analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and directly activates AMP-activated protein kinase (AMPK).

  • AMPK activation and energy metabolism
  • Exercise mimetic and endurance enhancement
  • Cardiac ischemia preconditioning
  • Autophagy and cellular quality control
Research Use Only.

This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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≥99% HPLC| COA Included| Ships Today
≥99% Purity
COA Included
Third-Party Tested
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HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18UV 220nmACN/H₂O + 0.1% TFA
CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
Same-Day Shipping
Batch Tracked

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS
2627-69-2
Mol. Weight
258.23 Da

How AICAR Works

AICAR is a cell-permeable nucleoside analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and directly activates AMP-activated protein kinase (AMPK). AMPK is the master cellular energy sensor that, when activated, switches on catabolic pathways (fatty acid oxidation, glucose uptake, autophagy) and switches off anabolic pathways (lipogenesis, protein synthesis, gluconeogenesis). AICAR has been termed an "exercise mimetic" because it activates the same AMPK-PGC-1alpha pathway triggered by exercise.

Research Applications

1
AMPK activation and energy metabolism
2
Exercise mimetic and endurance enhancement
3
Cardiac ischemia preconditioning
4
Autophagy and cellular quality control
5
Diabetes and insulin sensitivity research

Pricing

SizePer Vial10-Pack
50mg
$40.00$400.00
100mgBest Value
$65.00$650.00

10-pack pricing shown. Volume discounts for 50+ vials — contact us.

Certificate of Analysis

MiPeptidos
AICAR
PASSES ALL SPECIFICATIONS
Batch NumberHR-AICA-2600315
Date of AnalysisMarch 5, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)258.23 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.