AICAR - Front - MiPeptidos
Specialty / Research

AICAR

CAS: 2627-69-2

AICAR is a research peptide in the specialty / research category. AICAR is a cell-permeable nucleoside analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and directly activates AMP-activated protein kinase (AMPK). MiPeptidos offers AICAR in 2 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$22.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How AICAR Works

AICAR is a cell-permeable nucleoside analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and directly activates AMP-activated protein kinase (AMPK). AMPK is the master cellular energy sensor that, when activated, switches on catabolic pathways (fatty acid oxidation, glucose uptake, autophagy) and switches off anabolic pathways (lipogenesis, protein synthesis, gluconeogenesis). AICAR has been termed an "exercise mimetic" because it activates the same AMPK-PGC-1alpha pathway triggered by exercise.

Research Applications

1
AMPK activation and energy metabolism
2
Exercise mimetic and endurance enhancement
3
Cardiac ischemia preconditioning
4
Autophagy and cellular quality control
5
Diabetes and insulin sensitivity research
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
50mg
$22.95$167.95
100mgBest Value
$37.95$276.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
AICAR
PASSES ALL SPECIFICATIONS
Batch NumberHR-AICA-2600315
Date of AnalysisMarch 5, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)258.23 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
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Select a different concentration for a practical volume

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed AICAR product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Michael Thompson·Chicago, IL

AICAR from MiPeptidos is our primary AMPK activator for metabolic research. HPLC-verified purity is critical for our enzyme kinetics studies comparing direct AMPK activation with exercise-mimetic compounds. We run it alo...

Feb 21, 2026
View All Reviews →

Frequently Asked Questions

AICAR (CAS: 2627-69-2) is a research compound, with a molecular weight of 258.23 Da in the Specialty / Research category. AICAR is a cell-permeable nucleoside analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and directly activates AMP-activated protein kinase (AMPK). AMPK is the master cellular energy sensor that, when activated, switches on catabolic pathways (fatty acid oxidation, glucose uptake, autophagy) and switches off anabolic pathways (lipogenesis, protein synthesis, gluconeogenesis). Researchers commonly investigate AICAR for AMPK activation and energy metabolism, Exercise mimetic and endurance enhancement, Cardiac ischemia preconditioning. Every vial from MiPeptidos includes batch-specific analytical documentation.
AICAR is available in 2 sizes (50mg, 100mg), so reconstitution volume depends on which vial you have. For the 50mg size, add 5-6mL of bacteriostatic water; for the 100mg size, use 6-8mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted AICAR at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
AICAR (Acadesine, 258 Da) and SLU-PP-332 (290 Da) are both exercise mimetics, but they activate different pathways. AICAR is phosphorylated to ZMP, which directly activates AMP-activated protein kinase (AMPK) — the master sensor of cellular energy status. SLU-PP-332 activates estrogen-related receptors (ERRs) for mitochondrial biogenesis instead. AICAR mimics the energy-depleted state of exercise; SLU-PP-332 mimics the adaptive transcriptional response. MiPeptidos offers both for metabolic research.
Store lyophilized AICAR at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, AICAR has a reported half-life of ~1.5-2.5 hours, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every AICAR order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-AICA-2600315, tested March 5, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at 258.23 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
2627-69-2
Mol. Weight
258.23 Da
Formula
C9H14N4O5
Half-Life
~1.5-2.5 hours
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
50mg, 100mg

Sequence

N/A (not a peptide; nucleoside analog / AMPK activator)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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