GDF-8 - Front - MiPeptidos
Specialty / Research

GDF-8

CAS: Not formally assigned for recombinant research peptide

GDF-8 is a research peptide in the specialty / research category. Myostatin (GDF-8) is a secreted TGF-beta superfamily member that serves as the principal negative regulator of skeletal muscle mass. MiPeptidos offers GDF-8 in 1 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$86.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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Batch Tracked

How GDF-8 Works

Myostatin (GDF-8) is a secreted TGF-beta superfamily member that serves as the principal negative regulator of skeletal muscle mass. It signals through activin type IIB receptors (ActRIIB) and type I receptors (ALK4/ALK5), activating Smad2/3 transcription factors that suppress myogenic gene expression (MyoD, myogenin) and inhibit satellite cell activation, myoblast proliferation, and differentiation. Myostatin loss-of-function mutations produce dramatic muscle hypertrophy in multiple species. The propeptide remains associated with mature myostatin as an inhibitor until cleaved by BMP-1/tolloid proteases.

Research Applications

1
Muscle growth regulation and hypertrophy
2
Muscular dystrophy and muscle wasting research
3
Myostatin inhibitor development (drug target)
4
TGF-beta superfamily signaling
5
Livestock and agricultural muscle growth
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
1mg
$86.95$634.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
GDF-8
PASSES ALL SPECIFICATIONS
Batch NumberHR-GDF8-2600315
Date of AnalysisJanuary 1, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)~25,000 Da (mature homodimer); ~12,500 Da per monomer (109 amino acids each) — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
1.0 mL
1 mg GDF-8 + 1.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed GDF-8 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Tomasz Wojcik·Krakow, Poland

GDF-8 (myostatin) from MiPeptidos is essential as a positive control in our muscle wasting research. The TGF-beta family growth factor shows expected anti-myogenic activity in our C2C12 differentiation assays. Having a r...

Feb 14, 2026
View All Reviews →

Frequently Asked Questions

GDF-8 (CAS: Not formally assigned for recombinant research peptide) is a research compound, with a molecular weight of ~25,000 Da (mature homodimer); ~12,500 Da per monomer (109 amino acids each) in the Specialty / Research category. Myostatin (GDF-8) is a secreted TGF-beta superfamily member that serves as the principal negative regulator of skeletal muscle mass. It signals through activin type IIB receptors (ActRIIB) and type I receptors (ALK4/ALK5), activating Smad2/3 transcription factors that suppress myogenic gene expression (MyoD, myogenin) and inhibit satellite cell activation, myoblast proliferation, and differentiation. Researchers commonly investigate GDF-8 for Muscle growth regulation and hypertrophy, Muscular dystrophy and muscle wasting research, Myostatin inhibitor development (drug target). Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your GDF-8 1mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 1mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted GDF-8 at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
GDF-8 (Myostatin) IS the target that FST-344 and ACE-031 both inhibit — it is the endogenous negative regulator of muscle growth. Researchers use recombinant GDF-8 as a positive control in myostatin signaling assays, to study Smad2/3 activation kinetics, or to establish dose-response curves for myostatin inhibitors. Loss-of-function mutations in myostatin produce the double-muscled phenotype seen in Belgian Blue cattle and whippet dogs. MiPeptidos offers GDF-8 for this specialized research niche.
Store lyophilized GDF-8 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, GDF-8 has a reported half-life of Circulates bound to propeptide; free active form has short half-life in plasma, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every GDF-8 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-GDF8-2600315, tested January 1, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at ~25,000 Da (mature homodimer); ~12,500 Da per monomer (109 amino acids each), endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
Not formally assigned for recombinant research peptide
Mol. Weight
~25,000 Da (mature homodimer); ~12,500 Da per monomer (109 amino acids each)
Formula
Protein (mature homodimer)
Half-Life
Circulates bound to propeptide; free active form has short half-life in plasma
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
1mg

Sequence

375-amino acid prepropeptide processed to a 109-amino acid mature form; active as a disulfide-linked homodimer containing the TGF-beta superfamily cystine knot

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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