Dermorphin - Front - MiPeptidos
Specialty / Research

Dermorphin

CAS: 77614-16-5

Dermorphin is a research peptide in the specialty / research category. Dermorphin is a natural opioid heptapeptide isolated from the skin of South American Phyllomedusa frogs. MiPeptidos offers Dermorphin in 2 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$13.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
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How Dermorphin Works

Dermorphin is a natural opioid heptapeptide isolated from the skin of South American Phyllomedusa frogs. It binds with extremely high affinity and selectivity to mu-opioid receptors (MOR), where it acts as a potent full agonist. Dermorphin is approximately 30-40 times more potent than morphine as an analgesic. The D-Ala2 residue confers exceptional resistance to enzymatic degradation, making it one of the first naturally occurring D-amino acid-containing peptides discovered. It activates Gi/Go signaling to inhibit adenylyl cyclase, open potassium channels, and close calcium channels in pain pathways.

Research Applications

1
Mu-opioid receptor selectivity and pharmacology
2
D-amino acid-containing natural peptide biology
3
Pain modulation and analgesia research
4
Opioid receptor structure-activity relationships
5
Amphibian peptide biochemistry
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
2mg
$13.95$101.95
10mgBest Value
$25.95$188.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Dermorphin
PASSES ALL SPECIFICATIONS
Batch NumberHR-DRMR-2600215
Date of AnalysisJanuary 17, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)802.88 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
2.0 mL
2 mg Dermorphin + 2.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Dermorphin product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Ana Castillo·Lima, Peru

Dermorphin from MiPeptidos is a potent mu-opioid receptor agonist used in our pain receptor pharmacology studies. The frog-derived heptapeptide with D-Ala2 shows expected high-affinity binding in our receptor displacemen...

Dec 5, 2025
View All Reviews →

Frequently Asked Questions

Dermorphin (CAS: 77614-16-5) is a research compound, with a molecular weight of 802.88 Da in the Specialty / Research category. Dermorphin is a natural opioid heptapeptide isolated from the skin of South American Phyllomedusa frogs. It binds with extremely high affinity and selectivity to mu-opioid receptors (MOR), where it acts as a potent full agonist. Researchers commonly investigate Dermorphin for Mu-opioid receptor selectivity and pharmacology, D-amino acid-containing natural peptide biology, Pain modulation and analgesia research. Every vial from MiPeptidos includes batch-specific analytical documentation.
Dermorphin is available in 2 sizes (2mg, 10mg), so reconstitution volume depends on which vial you have. For the 2mg size, add 1mL of bacteriostatic water; for the 10mg size, use 2-3mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted Dermorphin at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
Dermorphin and DSIP are both naturally occurring peptides with CNS activity, but they target completely different systems. Dermorphin is a mu-opioid receptor full agonist (30-40x more potent than morphine) isolated from frog skin, while DSIP modulates delta-wave sleep architecture through GABAergic and somatostatin pathways without opioid activity. Dermorphin D-Ala2 residue — one of the first natural D-amino acids discovered — gives it exceptional protease resistance. MiPeptidos offers both for distinct CNS research.
Store lyophilized Dermorphin at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Dermorphin has a reported half-life of Extended vs. endogenous enkephalins due to D-Ala2; exact PK varies by route, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Dermorphin order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-DRMR-2600215, tested January 17, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at 802.88 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
77614-16-5
Mol. Weight
802.88 Da
Formula
C40H50N8O10
Half-Life
Extended vs. endogenous enkephalins due to D-Ala2; exact PK varies by route
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
2mg, 10mg

Sequence

Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (heptapeptide; contains D-alanine)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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