Cortagen - Front - MiPeptidos
Specialty / Research

Cortagen

CAS: 335591-03-2

Cortagen is a research peptide in the specialty / research category. Cortagen is a synthetic tetrapeptide bioregulator that acts primarily on the brain and central nervous system. MiPeptidos offers Cortagen in 1 sizes with 99.4% verified purity and full analytical documentation.

Starting at
$39.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How Cortagen Works

Cortagen is a synthetic tetrapeptide bioregulator that acts primarily on the brain and central nervous system. It interacts with DNA regulatory sequences in neural cells to modulate gene expression related to antioxidant enzyme production, neurotransmitter synthesis, and the balance between pro-oxidant and antioxidant processes. Cortagen has been shown to normalize cerebral cortex function, restore the balance of excitatory and inhibitory neurotransmission, and protect neurons from oxidative damage in aging models.

Research Applications

1
CNS bioregulation and neuroprotection
2
Oxidative stress balance in neural tissue
3
Age-related cognitive decline
4
Cerebral cortex function restoration
5
Bioregulator peptide (Khavinson peptide) platform
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
20mg
$39.95$291.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.4%purity
mAURetention Time (min)0250500750100005101520253099.4%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Cortagen
PASSES ALL SPECIFICATIONS
Batch NumberHR-CRTG-2600315
Date of AnalysisJanuary 4, 2026
Purity (HPLC)99.4%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)430.40 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
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Select a different concentration for a practical volume

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Cortagen product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Yoko Ishikawa·Kobe, Japan

Cortagen is a cortex-specific bioregulatory peptide for our CNS research. The tetrapeptide from MiPeptidos shows expected neuroprotective gene activation in our cortical neuron cultures. Our Japanese lab appreciates the...

Feb 26, 2026
View All Reviews →

Frequently Asked Questions

Cortagen (CAS: 335591-03-2) is a research compound, with a molecular weight of 430.40 Da in the Specialty / Research category. Cortagen is a synthetic tetrapeptide bioregulator that acts primarily on the brain and central nervous system. It interacts with DNA regulatory sequences in neural cells to modulate gene expression related to antioxidant enzyme production, neurotransmitter synthesis, and the balance between pro-oxidant and antioxidant processes. Researchers commonly investigate Cortagen for CNS bioregulation and neuroprotection, Oxidative stress balance in neural tissue, Age-related cognitive decline. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your Cortagen 20mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 3-5mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted Cortagen at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
Cortagen (Ala-Glu-Asp-Pro, 430 Da) is the cerebral cortex-targeting member of the Khavinson tetrapeptide family, while Cardiogen (489 Da) targets cardiac tissue. Cortagen proline C-terminus directs it toward neuronal gene expression regulation and neuroprotection. It has been studied in Russian literature for age-related cognitive decline and neurodegenerative conditions. The tetrapeptide bioregulator approach pioneered by Khavinson represents a unique field of peptide pharmacology. MiPeptidos stocks the complete set.
Store lyophilized Cortagen at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Cortagen has a reported half-life of Short; rapidly absorbed and distributed as an ultrashort peptide, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Cortagen order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-CRTG-2600315, tested January 4, 2026) shows 99.4% purity by HPLC, mass spectrometry confirmation at 430.40 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
335591-03-2
Mol. Weight
430.40 Da
Formula
C17H26N4O9
Half-Life
Short; rapidly absorbed and distributed as an ultrashort peptide
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
20mg

Sequence

Ala-Glu-Asp-Pro (tetrapeptide)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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