5-AMINO-1MQ - Front - MiPeptidos
Specialty / Research

5-AMINO-1MQ

CAS: 42464-96-0

5-AMINO-1MQ is a research peptide in the specialty / research category. 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that methylates and inactivates nicotinamide (a NAD+ precursor). MiPeptidos offers 5-AMINO-1MQ in 2 sizes with 99.3% verified purity and full analytical documentation.

Starting at
$16.95/vial
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≥99% Purity
COA Included
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How 5-AMINO-1MQ Works

5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that methylates and inactivates nicotinamide (a NAD+ precursor). By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD+ and S-adenosylmethionine (SAM) levels, activating SIRT1 and other NAD+-dependent metabolic enzymes. This leads to increased energy expenditure, enhanced fatty acid oxidation, reduced lipogenesis, and decreased adipocyte size. It effectively reverses diet-induced obesity in preclinical models without affecting food intake.

Research Applications

1
NNMT inhibition and adipose tissue metabolism
2
NAD+ salvage pathway enhancement
3
Obesity treatment without appetite suppression
4
Metabolic syndrome and insulin resistance
5
Epigenetic regulation of fat metabolism
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$16.95$123.95
10mgBest Value
$22.95$167.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.3%purity
mAURetention Time (min)0250500750100005101520253099.3%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
5-AMINO-1MQ
PASSES ALL SPECIFICATIONS
Batch NumberHR-5MN1-2600315
Date of AnalysisMarch 7, 2026
Purity (HPLC)99.3%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)159.21 Da (free base); 286.11 Da (iodide salt) — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg 5-AMINO-1MQ + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed 5-AMINO-1MQ product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Stephanie Alvarez·San Antonio, TX

5-Amino-1MQ from MiPeptidos is our primary NNMT inhibitor for adipocyte metabolism studies. The small molecule shows expected inhibition of nicotinamide N-methyltransferase and the resulting NAD+ salvage pathway activati...

Mar 7, 2026
View All Reviews →

Frequently Asked Questions

5-AMINO-1MQ (CAS: 42464-96-0) is a research compound, with a molecular weight of 159.21 Da (free base); 286.11 Da (iodide salt) in the Specialty / Research category. 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that methylates and inactivates nicotinamide (a NAD+ precursor). By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD+ and S-adenosylmethionine (SAM) levels, activating SIRT1 and other NAD+-dependent metabolic enzymes. Researchers commonly investigate 5-AMINO-1MQ for NNMT inhibition and adipose tissue metabolism, NAD+ salvage pathway enhancement, Obesity treatment without appetite suppression. Every vial from MiPeptidos includes batch-specific analytical documentation.
5-AMINO-1MQ is available in 2 sizes (5mg, 10mg), so reconstitution volume depends on which vial you have. For the 5mg size, add 1-2mL of bacteriostatic water; for the 10mg size, use 2-3mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted 5-AMINO-1MQ at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
5-Amino-1MQ and direct NAD+ supplementation both increase cellular NAD+ levels, but through opposite approaches. 5-Amino-1MQ inhibits NNMT (the enzyme that destroys nicotinamide, a NAD+ precursor), indirectly boosting NAD+ by preserving its precursor supply. Direct NAD+ injection provides the finished coenzyme immediately. 5-Amino-1MQ also increases SAM levels and activates SIRT1, and uniquely reduces adipocyte size without suppressing appetite. MiPeptidos offers both.
Store lyophilized 5-AMINO-1MQ at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, 5-AMINO-1MQ has a reported half-life of Not fully characterized in humans; preclinical data suggest oral dosing efficacy, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every 5-AMINO-1MQ order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-5MN1-2600315, tested March 7, 2026) shows 99.3% purity by HPLC, mass spectrometry confirmation at 159.21 Da (free base); 286.11 Da (iodide salt), endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
42464-96-0
Mol. Weight
159.21 Da (free base); 286.11 Da (iodide salt)
Formula
C10H11N2 (free base cation)
Half-Life
Not fully characterized in humans; preclinical data suggest oral dosing efficacy
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg, 10mg

Sequence

N/A (not a peptide; small molecule quinolinium compound)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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