Nootropic Pathway Study Kit

Semax is a synthetic heptapeptide analog of ACTH(4-10) with a stabilizing Pro-Gly-Pro extension. It increases BDNF and TrkB receptor expression, enhances neurotrophic factor signaling, modulates dopaminergic and serotonergic neurotransmission, and provides neuroprotection through antioxidant and inflammatory-pathway mechanisms. Unlike ACTH, Semax has no steroidogenic activity. It improves cerebral circulation, enhances memory consolidation, and has been approved in Russia and Ukraine for stroke recovery and cognitive enhancement.

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension that enhances metabolic stability. It modulates the balance of Th1/Th2 cytokines, influences enkephalinase activity, and increases BDNF mRNA expression in the hippocampus. Selank produces anxiolytic effects comparable to benzodiazepines without sedation, cognitive impairment, or dependence by modulating GABAergic neurotransmission and monoamine metabolism in limbic structures.

Dihexa is a small, orally active, blood-brain barrier-permeable oligopeptide derivative of angiotensin IV. It acts as an allosteric agonist of the hepatocyte growth factor (HGF)/c-Met receptor system, potentiating HGF signaling at picomolar concentrations. This drives neurogenesis, synaptogenesis, and spinogenesis in the hippocampus. Dihexa is reportedly 10 million times more potent than BDNF in promoting neurite outgrowth. It also enhances synaptic plasticity and long-term potentiation, the cellular basis of learning and memory.