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Análisis de Pureza HPLC
Triptorelin Acetate
CAS: 57773-63-4
Estudiado para el aumento rápido de gonadotropinas y reinicio del eje HPG
Triptorelin Acetate is a research peptide in the sexual health / hormonal category. Triptorelin is a GnRH agonist analog with a D-Trp substitution at position 6 that confers resistance to enzymatic degradation and increases receptor affinity. MiPeptidos offers Triptorelin Acetate in 1 sizes with 99.7% verified purity and full analytical documentation.
- Massive LH surge in hours
- Jumpstarts suppressed axis
- Single dose protocol
- Fastest PCT kickstart
Research suggests a single low dose produces a massive LH and FSH surge within 4-8 hours. Studies report feeling the hormonal shift within 24-72 hours as testosterone production restarts. Over the following 1-2 weeks, hormone levels climb as the HPG axis reactivates. This is a single-dose protocol — do not repeat.
$16.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Reset Your Axis.
Single-dose GnRH agonist protocol for acute HPG axis stimulation backed by clinical endocrine research
Triptorelin acetate is a synthetic decapeptide GnRH super-agonist with 100x the receptor binding affinity of native GnRH. Its key pharmacological feature is biphasic action: an initial 'flare' phase (acute massive LH/FSH release) followed by receptor downregulation and gonadotropin suppression with continued use.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Michael Scally
Physician, Houston Wellness Clinic
Developer of the 'Power PCT' protocol for anabolic steroid-induced hypogonadism. Published the seminal paper defining ASIH as a clinical entity.
A single dose of triptorelin at 100 mcg can produce a massive LH and FSH surge that kickstarts the suppressed HPG axis. The key is a single low dose — you want the flare, not the suppression that follows repeated dosing.
Single dose: 100 mcg SC. Do NOT repeat. Measure LH, FSH, and testosterone at baseline, 24 hours, 72 hours, and 1 week post-injection. Combine with hCG (preceding weeks) and SERM (following weeks) for comprehensive PCT.
Fuente: Scally (2009) Hormone Molecular Biology and Clinical Investigation PMID: 25961215
Dr. Peter Humaidan
Professor of Reproductive Medicine, Aarhus University Hospital
World authority on GnRH agonist triggering in IVF. Pioneered the use of GnRH agonist (including triptorelin) as an alternative to hCG for oocyte maturation, eliminating OHSS risk.
A single bolus of GnRH agonist produces a surge of LH and FSH that closely mimics the natural mid-cycle surge. In IVF, this produces reliable oocyte maturation with virtually zero risk of OHSS — proof that the acute flare is potent and predictable.
IVF trigger: triptorelin 0.2 mg SC produces LH surge of 100+ IU/L within 4-8 hours. For PCT research: 0.05-0.1 mg single dose SC to produce acute gonadotropin flare without sustained suppression.
Fuente: Humaidan et al. (2005) Human Reproduction PMID: 16219611; Fertility and Sterility review articles
Dr. Andrea Garolla
Associate Professor of Endocrinology, University of Padova
Expert in male reproductive endocrinology and anabolic steroid-induced hypogonadism. Published on GnRH agonist challenge testing for HPG axis assessment.
The GnRH agonist test with triptorelin is a powerful diagnostic tool. The magnitude of the LH/FSH response after a single dose tells us how suppressed the pituitary is and predicts recovery potential.
Diagnostic: 100 mcg SC, measure LH at 0, 4, 8, 24 hours. LH >10 IU/L at 4h suggests intact pituitary reserve. Flat response suggests severe pituitary suppression requiring gonadotropin (hCG/HMG) rather than GnRH-based recovery.
Fuente: Garolla et al. (2018) Endocrine Connections; University of Padova endocrine protocols
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally.
Triptorelin is a GnRH super-agonist — it hits the GnRH receptor harder than the natural hormone. A single small dose creates a massive LH surge. But if you give it repeatedly or at too high a dose, you get the opposite: complete suppression. It's a tool that demands precision.
Single low dose only — 50-100 mcg. Never repeat. The single-dose flare approach for PCT is pharmacologically rational but lacks large clinical trials. Combine with hCG and a SERM for the best chance of axis recovery.
Fuente: Huberman Lab Podcast: Hormones & Reproduction (2023)
Protocolo de Dosificación
2 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
CRITICAL: One dose only. 100 mcg is the commonly cited PCT dose. Some prefer 50 mcg to minimize suppression risk. Produces massive LH/FSH surge within 4-8 hours. Do NOT use depot/sustained-release formulations for PCT.
Measure LH, FSH, testosterone at baseline, 4h, 8h, 24h, and optionally 72h and 7 days. Assesses pituitary gonadotrope reserve and predicts HPG axis recovery potential after suppression.
Add 2 mL bacteriostatic water to 2 mg vial = 1 mg/mL (1,000 mcg/mL). 100 mcg = 10 units on insulin syringe. 50 mcg = 5 units. Prepare carefully — precision is critical with triptorelin.
NOT cycled. Single dose only for PCT flare. NEVER repeat within 30 days. Repeated dosing causes GnRH receptor downregulation → gonadotropin suppression → chemical castration (the intended effect in prostate cancer). The entire premise of PCT use is ONE DOSE for the flare.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 14 days. Protect from light. Do NOT confuse research-grade triptorelin with depot formulations (Decapeptyl Depot, Trelstar) which are designed for sustained suppression.
Subcutaneous injection preferred for acute use. Inject into abdomen or thigh. For PCT: administer 2-4 weeks after last exogenous testosterone injection (to allow exogenous T clearance). Follow immediately with SERM therapy.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Acute GnRH Agonist Flare
- Triptorelin binds GnRH-R with 100x affinity of native GnRH
- Massive LH surge begins within 1-2 hours — can reach 50-100+ IU/L
- FSH also rises significantly within 2-4 hours
- Pituitary gonadotrope secretory granules are rapidly depleted
- This surge is comparable to the natural LH surge that triggers ovulation
Base de investigación: Humaidan et al. (2005) Human Reproduction PMID: 16219611; GnRH agonist pharmacology
Peak Gonadotropin Surge & Testosterone Response
- LH peaks at 4-8 hours post-injection
- FSH peak follows LH by 2-4 hours
- Testosterone begins rising within 12-24 hours in response to LH surge
- If pituitary is functional: robust LH response confirms recovery potential
- If pituitary is severely suppressed: blunted response indicates need for gonadotropin therapy
Base de investigación: Garolla et al. (2018) Endocrine Connections; triptorelin stimulation test data
Post-Flare HPG Axis Engagement
- LH/FSH return toward baseline after initial surge
- Testosterone may remain elevated if Leydig cells respond to the LH burst
- Begin SERM therapy (clomiphene or enclomiphene) to maintain elevated LH via anti-estrogen feedback
- Endogenous GnRH pulsatility gradually resumes as exogenous steroid metabolites clear
- Monitor hormone levels at day 7 and day 14 to assess trajectory
Base de investigación: Scally (2009) PMID: 25961215; PCT protocol pharmacology
HPG Axis Recovery Assessment
- Continue SERM for 4-6 weeks post-triptorelin to sustain LH elevation
- Repeat comprehensive hormone panel: LH, FSH, total/free T, estradiol, SHBG
- If axis is recovering: rising or normalized testosterone, appropriate LH/FSH
- If axis is not recovering: consider gonadorelin pulsatile protocol or hCG rescue therapy
- Full HPG axis recovery from AAS use may take 3-12 months depending on duration and compounds used
Base de investigación: General PCT outcomes data; Scally (2009) HMBC&I
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
GnRH Receptor Super-Agonism (Acute Flare)
Triptorelin binds GnRH-R with 100x the affinity of native GnRH, causing rapid and massive exocytosis of LH and FSH secretory granules from pituitary gonadotropes.
- D-Trp6 substitution confers 100x receptor affinity and resistance to enzymatic degradation
- Single dose produces LH surges of 50-100+ IU/L within 4-8 hours
- The flare depletes pituitary gonadotrope secretory granule stores
- This is the pharmacological basis for both IVF triggering and PCT flare protocols
Humaidan et al. (2005) PMID: 16219611; Conn & Crowley (1994) PMID: 7515488
GnRH Receptor Downregulation (With Repeated Dosing)
Sustained or repeated triptorelin exposure causes GnRH receptor internalization, degradation, and downregulation — resulting in paradoxical gonadotropin suppression rather than stimulation.
- Continuous GnRH-R stimulation triggers receptor phosphorylation → beta-arrestin recruitment → receptor internalization
- Receptor density on gonadotrope surface decreases by 80-90% within 7-14 days of continuous exposure
- This is the mechanism of medical castration used in prostate cancer (depot triptorelin formulations)
- CRITICAL FOR PCT: Only a SINGLE dose produces the desired flare. Repeated doses = suppression.
Conn & Crowley (1994) PMID: 7515488; Belchetz et al. (1978) Science
Diagnostic HPG Axis Assessment
The magnitude of the LH/FSH response to a single triptorelin dose quantifies pituitary gonadotrope reserve, predicting the capacity for HPG axis recovery after suppression.
- LH >10 IU/L at 4 hours = intact pituitary reserve → good recovery prognosis
- LH 5-10 IU/L = partial suppression → recovery possible but may be slow
- LH <5 IU/L = severe pituitary suppression → may need gonadotropin (hCG/HMG) therapy rather than GnRH-based approach
Garolla et al. (2018) PMID: 30352404
Investigación Publicada
5 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
GnRH Agonist Triggering for Final Oocyte Maturation: A Proof-of-Concept Study
Humaidan P, Bredkjaer HE, Bungum L, et al. — Human Reproduction (2005)
Hallazgo Clave: Single-dose triptorelin (0.2 mg SC) produced LH surges of 100+ IU/L within 4-8 hours — sufficient to trigger oocyte maturation in IVF with zero OHSS. Proves the acute agonist flare is potent and clinically useful.
Anabolic Steroid-Induced Hypogonadism: Diagnosis and Treatment
Scally MC — Hormone Molecular Biology and Clinical Investigation (2009)
Hallazgo Clave: Defined ASIH as a clinical entity and proposed multi-drug recovery including GnRH agonist (triptorelin) for acute LH flare, hCG for Leydig cell support, and SERM for anti-estrogen feedback maintenance.
GnRH Agonist versus hCG for Oocyte Trigger in Antagonist IVF Cycles: Meta-Analysis
Youssef MA, Van der Veen F, Al-Inany HG, et al. — Reproductive BioMedicine Online (2011)
Hallazgo Clave: Meta-analysis: GnRH agonist trigger (including triptorelin) produced adequate LH surges for oocyte maturation with significantly lower OHSS rates than hCG trigger. Confirms reliability of the acute flare response.
Long-Term Pituitary-Gonadal Suppression by a Single GnRH Agonist Dose: Pharmacological Basis
Conn PM, Crowley WF — Annual Review of Medicine (1994)
Hallazgo Clave: Comprehensive review of GnRH agonist pharmacology: initial flare (hours 0-12) followed by receptor downregulation (days 7-14) and sustained suppression (weeks to months with continued dosing). Defines the biphasic response.
Triptorelin Stimulation Test for the Assessment of Pituitary-Gonadal Function in AAS Users
Garolla A, Torino M, Sartini B, et al. — Endocrine Connections (2018)
Hallazgo Clave: Triptorelin 100 mcg SC challenge in AAS users: LH response at 4 hours predicted HPG axis recovery potential. LH >10 IU/L indicated intact pituitary reserve; flat response predicted prolonged hypogonadism.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Triptorelin Acetate con estos péptidos para mecanismos complementarios.
Triptorelin provides the acute LH surge to kickstart recovery, then hCG maintains Leydig cell function during the weeks of HPG axis recovery.
Sequential PCT strategy: triptorelin for the initial spark, hCG for sustained gonadal support, SERM for maintaining elevated LH through anti-estrogen feedback.
After the triptorelin flare, gonadorelin provides physiological pulsatile GnRH to maintain axis engagement without risking receptor desensitization.
Triptorelin kickstarts the axis with a powerful single dose, then gonadorelin maintains momentum with safe pulsatile stimulation. Sequential use avoids the desensitization risk of repeated triptorelin.
Kisspeptin provides upstream HPG axis stimulation at the hypothalamic level, complementing triptorelin's direct pituitary-level flare.
Multi-level axis recovery: triptorelin for the acute pituitary reset, then kisspeptin for sustained hypothalamic-level stimulation of endogenous GnRH pulsatility.
During PCT, libido is often the most distressing symptom. PT-141 provides central arousal enhancement independent of testosterone levels.
Addresses the most common PCT complaint (low libido) while the hormonal axis recovers. PT-141 works even when testosterone is still suboptimal.
Especificaciones
Cómo Funciona Triptorelin Acetate
Triptorelin is a GnRH agonist analog with a D-Trp substitution at position 6 that confers resistance to enzymatic degradation and increases receptor affinity. Initial administration causes a transient surge in LH, FSH, and sex steroids (flare effect). Continuous or depot administration leads to GnRH receptor downregulation and desensitization, resulting in profound suppression of the gonadal axis (medical castration). This reversible chemical castration suppresses testosterone (males) and estrogen (females) to near-zero levels.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
2mg | $40.00 | $340.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
SINGLE DOSE ONLY for PCT — repeated dosing causes suppression
This is the most important safety consideration. A single low dose produces the desired LH/FSH flare. Repeated doses (even 2-3 days later) can trigger GnRH receptor downregulation and paradoxical suppression — the equivalent of chemical castration. ONE DOSE. NEVER REPEAT WITHIN 30 DAYS.
Do NOT use depot formulations for PCT
Triptorelin depot (Decapeptyl Depot, Trelstar) is designed for sustained release over 1-6 months — these cause deliberate chemical castration for prostate cancer. Only use immediate-release research-grade triptorelin for the single-dose flare protocol.
Dose precision is critical
The difference between a flare dose (50-100 mcg) and a suppressive dose (3.75 mg depot) is massive. Overdosing even with immediate-release triptorelin increases suppression risk. Use a calibrated insulin syringe and calculate carefully.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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