Melanotan I - Front - MiPeptidos
Sexual Health / Hormonal

Melanotan I

CAS: 75921-69-6

Melanotan I is a research peptide in the sexual health / hormonal category. Melanotan I is a synthetic linear analog of alpha-melanocyte stimulating hormone (alpha-MSH) with Nle4 and D-Phe7 substitutions that confer enhanced potency and metabolic stability. MiPeptidos offers Melanotan I in 1 sizes with 99.8% verified purity and full analytical documentation.

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$34.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How Melanotan I Works

Melanotan I is a synthetic linear analog of alpha-melanocyte stimulating hormone (alpha-MSH) with Nle4 and D-Phe7 substitutions that confer enhanced potency and metabolic stability. It activates melanocortin 1 receptors (MC1R) on melanocytes, stimulating the cAMP/PKA pathway to upregulate tyrosinase and increase eumelanin production, resulting in skin tanning. It also has anti-inflammatory and photoprotective properties. It is approved in Europe (Scenesse) for erythropoietic protoporphyria.

Research Applications

1
Photoprotection and UV damage prevention
2
Melanogenesis and tanning mechanisms
3
Erythropoietic protoporphyria treatment
4
Skin cancer prevention
5
Melanocortin receptor selectivity studies
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$34.95$254.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.8%purity
mAURetention Time (min)0250500750100005101520253099.8%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Melanotan I
PASSES ALL SPECIFICATIONS
Batch NumberHR-MLNT-2600315
Date of AnalysisJanuary 16, 2026
Purity (HPLC)99.8%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)1646.87 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg Melanotan I + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Melanotan I product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Lucas Oliveira·Rio de Janeiro, Brazil

Melanotan I (afamelanotide) from MiPeptidos is a linear alpha-MSH analog essential for our melanogenesis and photoprotection research. The tridecapeptide shows expected MC1R activation and melanin production in our melan...

Nov 28, 2025
View All Reviews →

Frequently Asked Questions

Melanotan I (CAS: 75921-69-6) is a research compound, with a molecular weight of 1646.87 Da in the Sexual Health / Hormonal category. Melanotan I is a synthetic linear analog of alpha-melanocyte stimulating hormone (alpha-MSH) with Nle4 and D-Phe7 substitutions that confer enhanced potency and metabolic stability. It activates melanocortin 1 receptors (MC1R) on melanocytes, stimulating the cAMP/PKA pathway to upregulate tyrosinase and increase eumelanin production, resulting in skin tanning. Researchers commonly investigate Melanotan I for Photoprotection and UV damage prevention, Melanogenesis and tanning mechanisms, Erythropoietic protoporphyria treatment. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your Melanotan I 10mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 2-3mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted Melanotan I at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
Melanotan I (afamelanotide, 1647 Da) is a linear 13-amino acid alpha-MSH analog that selectively activates MC1R for melanogenesis (skin darkening and photoprotection) with minimal MC4R sexual arousal effects. Melanotan II (1024 Da) is a shorter cyclic heptapeptide that hits both MC1R and MC4R, producing tanning plus sexual function effects. Melanotan I is approved in Europe as Scenesse for erythropoietic protoporphyria. MiPeptidos offers both melanocortin peptides.
Store lyophilized Melanotan I at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Melanotan I has a reported half-life of ~30 minutes to 2 hours, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Melanotan I order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-MLNT-2600315, tested January 16, 2026) shows 99.8% purity by HPLC, mass spectrometry confirmation at 1646.87 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
75921-69-6
Mol. Weight
1646.87 Da
Formula
C78H111N21O19
Half-Life
~30 minutes to 2 hours
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg

Sequence

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 (13 amino acids; linear alpha-MSH analog)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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