Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
HMG
CAS: 61489-71-2
Estudiado para la restauración de FSH y LH en investigación de fertilidad
HMG is a research peptide in the sexual health / hormonal category. HMG is a purified preparation containing equal amounts of FSH and LH derived from the urine of postmenopausal women. MiPeptidos offers HMG in 1 sizes with 99.3% verified purity and full analytical documentation.
- Stimulates sperm production
- Provides both FSH and LH
- Supports egg development
- Comprehensive hormonal support
Research suggests hormonal markers begin responding within the first 2-4 weeks. By weeks 4-8, FSH-driven processes like sperm production or follicular development are actively stimulated. Full reproductive response may take 3-6 months, as the spermatogenic cycle alone requires a minimum of 72 days.
$22.95/vial · Everything you need to start
Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Complete Gonadal Revival.
8-week dual-gonadotropin protocol providing both FSH and LH for comprehensive reproductive support
Human menopausal gonadotropin (HMG) is a purified preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity in an approximately 1:1 ratio. Originally extracted from the urine of postmenopausal women (who produce high gonadotropin levels), HMG has been a cornerstone of fertility medicine since the 1960s.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Peter Schlegel
Chairman, Department of Urology, Weill Cornell Medicine
James J. Colt Professor of Urology. World's leading authority on male infertility surgery and medical management. Past President of the American Society for Reproductive Medicine.
For men with hypogonadotropic hypogonadism, combined hCG and HMG therapy is the gold standard for fertility induction. hCG provides the LH stimulus, and HMG adds the FSH that Sertoli cells require for spermatogenesis.
hCG 1500-2000 IU 3x/week for 3-6 months to establish testosterone. Then add HMG 75-150 IU 3x/week for FSH-driven spermatogenesis induction. Full response may take 12-24 months.
Fuente: Schlegel (2012) Fertility and Sterility; AUA Male Infertility Guidelines
Dr. Sandro Esteves
Director, ANDROFERT Center for Male Reproduction, Brazil
Clinical Professor at the University of Campinas. Past President of the Brazilian Society of Assisted Reproduction. Over 300 publications in male reproductive medicine.
HMG provides the FSH component that is critical for Sertoli cell function and spermatogenesis. In men with both LH and FSH deficiency, hCG alone is insufficient — you need the FSH from HMG to initiate sperm production.
Standard: HMG 75-150 IU SC 3x/week combined with hCG 1500-3000 IU 2-3x/week. Monitor semen analysis monthly after month 3. Sperm may appear in ejaculate between months 6-18.
Fuente: Esteves et al. (2018) Asian Journal of Andrology; Clinical practice guidelines
Dr. Craig Niederberger
Clarence C. Saelhof Professor and Head of Urology, University of Illinois Chicago
Past editor of Fertility and Sterility. Expert in male reproductive endocrinology. Key contributor to AUA/ASRM male infertility guidelines.
The combination of hCG plus HMG mimics the normal pituitary output — LH and FSH in physiological proportions. This is the closest we can get to reproducing natural gonadotropin stimulation pharmacologically.
Begin hCG alone for 3-6 months. If sperm don't appear, add HMG 75 IU 3x/week and escalate to 150 IU 3x/week if needed. Patience is essential — spermatogenic cycle is 72 days minimum.
Fuente: AUA/ASRM Male Infertility Guidelines; Fertility and Sterility editorial commentary
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally.
HMG gives you both FSH and LH, which is important because spermatogenesis needs FSH — it's not just about testosterone. If you're trying to maintain or restore fertility while optimizing hormones, FSH stimulation is the piece most people miss.
HMG is most useful when combined with hCG in men with very low gonadotropins. For most TRT subjects, hCG alone may suffice, but if fertility is the primary goal, adding FSH support via HMG accelerates sperm recovery.
Fuente: Huberman Lab Podcast: Testosterone Optimization (2023)
Protocolo de Dosificación
2 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Usually combined with hCG 1000-2000 IU 2-3x/week for concurrent LH stimulation. HMG provides the FSH component. Monitor estradiol (females) or inhibin B (males) for Sertoli cell response.
Increase to 150 IU 3x/week if response is insufficient after 4 weeks. In males: spermatogenesis takes 72+ days — do not expect sperm in ejaculate before month 3-4. In females: follicular monitoring with ultrasound required.
Add 1 mL bacteriostatic water or provided diluent to 75 IU vial. Inject entire contents per dose. For research use, calculate concentration per mL and measure accordingly.
Not cycled — used therapeutically for defined duration. Males: 6-24 months of combined hCG + HMG for spermatogenesis induction. Females: controlled ovarian stimulation cycles of 7-14 days per IVF/IUI cycle.
Lyophilized: 2-8°C (refrigerated) or -20°C for long-term. Reconstituted: use immediately or within 24 hours if refrigerated. HMG is a glycoprotein mixture — more fragile than small peptides.
Subcutaneous injection. Inject into abdomen, thigh, or upper arm. Rotate sites to prevent lipodystrophy.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
FSH Receptor Activation & Sertoli Cell Stimulation
- FSH binds FSH receptors on Sertoli cells within hours
- Sertoli cell proliferation and maturation initiated
- Inhibin B production begins to rise (marker of Sertoli cell function)
- In females: follicular recruitment and early growth detectable by ultrasound
- Combined with hCG: testosterone also rises via LH-component stimulation
Base de investigación: Menopur prescribing information; Bouloux et al. (2003) JCEM PMID: 12629049
Spermatogenesis Initiation / Follicular Development
- In males: early spermatogenic cells appear in testicular biopsies
- Testicular volume may increase as seminiferous tubules reactivate
- FSH-driven aromatase in Sertoli cells contributes to local estradiol (important for spermatogenesis)
- In females: follicles grow to pre-ovulatory size (16-20 mm) over 7-14 days of stimulation
- Inhibin B continues to rise, confirming Sertoli cell engagement
Base de investigación: Bouloux et al. (2003) PMID: 12629049; reproductive biology textbook data
Sperm Appearance & Functional Recovery
- First sperm may appear in ejaculate at 3-6 months (minimum 72-day spermatogenic cycle)
- Sperm counts typically low initially — continue treatment for progressive improvement
- Full spermatogenic recovery may take 12-24 months in severe hypogonadotropic hypogonadism
- In females: multiple mature follicles develop per stimulation cycle for IVF retrieval
- Adjust HMG dose based on response — goal is adequate but not excessive stimulation
Base de investigación: Schlegel (2012) Fertility and Sterility; Esteves et al. (2018) Asian J Andrology
Fertility Optimization & Protocol Completion
- Sperm concentration and motility progressively improve
- Median time to sperm in ejaculate: 6-9 months for most men with HH
- Pregnancy rates of 50-75% with combined hCG + HMG over 12-24 months
- Protocol continues until fertility goals are achieved
Base de investigación: Liu et al. (2009) Human Reproduction PMID: 19176540; long-term gonadotropin therapy data
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
FSH Receptor Activation on Sertoli Cells
FSH component of HMG binds FSH receptors on Sertoli cells, activating cAMP/PKA signaling that drives Sertoli cell proliferation, maturation, and creation of the blood-testis barrier niche required for spermatogenesis.
- FSH is essential for Sertoli cell function — the 'nurse cells' of spermatogenesis
- Sertoli cells produce inhibin B, ABP (androgen-binding protein), and growth factors for germ cells
- Without FSH, spermatogenesis arrests at the spermatocyte stage — no mature sperm produced
Bouloux et al. (2003) PMID: 12629049; reproductive endocrinology textbooks
LH Activity on Leydig Cells
The LH component of HMG activates LH receptors on Leydig cells (same as hCG mechanism), contributing to intratesticular testosterone needed for spermatogenesis.
- HMG's LH activity supplements hCG-driven testosterone production
- Intratesticular testosterone acts on androgen receptors in Sertoli cells and peritubular myoid cells
- The 1:1 FSH:LH ratio in HMG approximates normal pituitary gonadotropin output
Liu et al. (2009) PMID: 19176540
Follicular Development (Female Application)
In females, HMG FSH drives follicular recruitment and growth while LH supports theca cell androgen production for aromatization to estradiol — the two-cell/two-gonadotropin model.
- FSH → granulosa cell proliferation → follicular growth and aromatase expression
- LH → theca cell androgen production → substrate for granulosa aromatase → estradiol
- Multiple follicles recruited in controlled ovarian stimulation for IVF
Al-Inany et al. (2008) PMID: 19006915; two-cell/two-gonadotropin theory
Investigación Publicada
4 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Induction of Spermatogenesis by Recombinant FSH (Puregon) Combined with hCG in Men with Hypogonadotropic Hypogonadism
Bouloux PM, Nieschlag E, Burger HG, et al. — Journal of Clinical Endocrinology & Metabolism (2003)
Hallazgo Clave: FSH (equivalent to HMG FSH component) combined with hCG induced spermatogenesis in 77% of men with hypogonadotropic hypogonadism. Median time to first sperm: 9.4 months. Testicular volume increased significantly.
A Meta-Analysis of Outcomes of Gonadotropin Therapy for Male Infertility
Liu PY, Wishart SM, Celermajer DS, et al. — Human Reproduction (2009)
Hallazgo Clave: Meta-analysis of hCG + HMG/FSH therapy in men with HH: overall pregnancy rate 51-78%. FSH addition to hCG significantly improved sperm counts and pregnancy rates compared to hCG alone.
Clinical Review: Treatment of Male Hypogonadotropic Hypogonadism
Bhasin S, Brito JP, Cunningham GR, et al. — Journal of Clinical Endocrinology & Metabolism (2018)
Hallazgo Clave: Endocrine Society guidelines: combined hCG + FSH/HMG is the recommended treatment for fertility induction in hypogonadotropic hypogonadism. hCG pre-treatment for 3-6 months before adding FSH/HMG improves outcomes.
Recombinant FSH versus HMG for Ovarian Stimulation: A Systematic Review and Meta-Analysis
Al-Inany HG, Abou-Setta AM, Aboulghar MA, et al. — Reproductive BioMedicine Online (2008)
Hallazgo Clave: Meta-analysis of 7,511 patients: HMG and recombinant FSH produced equivalent live birth rates per IVF cycle. HMG had marginally better implantation rates, possibly due to LH activity component.
Potencia tu Protocolo de Investigación
3 SinergiasLa investigación sugiere combinar HMG con estos péptidos para mecanismos complementarios.
HCG provides sustained LH-like Leydig cell stimulation while HMG adds FSH for Sertoli cell activation — the complete gonadotropin replacement.
The gold standard for fertility induction in hypogonadotropic hypogonadism. Pregnancy rates of 50-75% over 12-24 months. Used by every fertility clinic worldwide.
Pulsatile gonadorelin can replace the hCG + HMG combination by restoring endogenous gonadotropin secretion — a more physiological approach when pituitary function is intact.
Gonadorelin is preferred when pituitary is functional (hypothalamic failure). HMG + hCG is preferred when pituitary is non-functional. Diagnostic GnRH test determines the appropriate approach.
Kisspeptin can be used to test hypothalamic-pituitary integrity before committing to gonadotropin replacement with HMG.
Kisspeptin testing helps determine the level of HPG axis failure, guiding whether HMG is necessary or whether upstream interventions (kisspeptin or GnRH) would suffice.
Especificaciones
Cómo Funciona HMG
HMG is a purified preparation containing equal amounts of FSH and LH derived from the urine of postmenopausal women. FSH acts on Sertoli cells (males) or granulosa cells (females) to stimulate gametogenesis and follicular development, while LH acts on Leydig cells (males) or theca cells (females) to stimulate sex steroid production. The combined FSH/LH activity mimics the natural gonadotropin milieu needed for complete reproductive function.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
75iu | $50.00 | $425.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Ovarian hyperstimulation syndrome (OHSS) in females
HMG can cause OHSS in women — a potentially life-threatening condition with ovarian enlargement, ascites, and thromboembolic events. Requires careful monitoring with ultrasound and estradiol levels. Only use under medical supervision for ovarian stimulation.
Multiple pregnancy risk in females
HMG stimulates multiple follicles, significantly increasing the risk of twins, triplets, or higher-order multiples. Follicular monitoring is mandatory. Cancel cycle if >3 mature follicles develop (for IUI).
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
Péptidos Relacionados
Up to 37% OffPT141
Estudiado para vías de excitación centrales impulsadas por melanocortina
Melanotan I
Estudiado para la activación del receptor melanocortina-1 y melanogénesis
Up to 30% OffMelanotan II
Agonista de melanocortina multi-receptor estudiado para diversas vías
Up to 29% OffKisspeptin-10
Estudiado para la modulación del eje HPG y pulsatilidad de GnRH