Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
HCG
CAS: 9002-61-3
Estudiado para mantener parámetros de fertilidad durante TRT
HCG is a research peptide in the sexual health / hormonal category. HCG is a glycoprotein hormone that shares structural homology with luteinizing hormone (LH) and binds to the same LH/CG receptor (LHCGR). MiPeptidos offers HCG in 4 sizes with 99.5% verified purity and full analytical documentation.
- Maintains natural T production
- Preserves fertility on TRT
- Prevents testicular atrophy
- Boosts energy and well-being
Studies report improved energy and well-being within the first 1-2 weeks. By weeks 4-8, research suggests measurable increases in intratesticular testosterone and maintained testicular volume. Over the full 12-week protocol, fertility markers remain supported, with semen quality preserved even alongside testosterone therapy.
$31.95/vial · Everything you need to start
Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Protect What Matters.
12-week fertility and testosterone protocol backed by decades of clinical evidence and 6 published studies
Human chorionic gonadotropin (hCG) is a glycoprotein hormone that shares the alpha subunit with LH, FSH, and TSH, but has a unique beta subunit that gives it LH-like biological activity with a dramatically longer half-life (24-36 hours vs 20 minutes for LH). This makes hCG the most practical tool for sustained Leydig cell stimulation.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. John Bremner
Professor of Medicine, University of Washington
Endocrinologist and lead researcher on hCG-testosterone combination therapy. Led the NIH-funded trials establishing hCG dosing for intratesticular testosterone maintenance.
Low-dose hCG co-treatment during testosterone administration maintains intratesticular testosterone, the critical local hormone concentration needed for spermatogenesis. Without it, TRT effectively sterilizes most men.
250-500 IU every other day alongside TRT to maintain intratesticular testosterone. Higher doses (1000-2000 IU 2-3x/week) for more aggressive testosterone production. Monitor estradiol — hCG increases aromatase activity.
Fuente: Coviello et al. (2008) JCEM PMID: 18728176; multiple UW publications
Dr. Abraham Morgentaler
Clinical Professor of Urology, Harvard Medical School
Founder of Men's Health Boston. Author of 'Testosterone for Life.' Pioneer in testosterone therapy who challenged the prostate cancer myth. Expert in male fertility preservation.
HCG is the most important adjunct to testosterone therapy for men who wish to preserve fertility. It maintains the Leydig cell machinery and intratesticular testosterone that exogenous testosterone suppresses.
Standard TRT adjunct: 500 IU SC 3x/week. For PCT: 1000-2000 IU every other day for 2-4 weeks. Always combine with TRT from the start rather than adding later — prevention is easier than recovery.
Fuente: 'Testosterone for Life' (2008); Journal of Urology; Fertility and Sterility publications
Dr. Mohit Khera
Professor of Urology, Baylor College of Medicine
Director of the Laboratory for Andrology Research. National authority on testosterone therapy and male fertility. AUA guidelines committee member.
For any man on testosterone therapy who wants to maintain fertility, hCG is non-negotiable. The data clearly shows that without LH-like stimulation, Leydig cells atrophy and intratesticular testosterone falls to levels incompatible with spermatogenesis.
500 IU SC every other day for fertility preservation during TRT. For older men or those with longer TRT duration: 1000-1500 IU 3x/week. Monitor hematocrit, estradiol, and semen analysis every 3-6 months.
Fuente: Khera (2016) Urology Clinics of North America; AUA TRT guidelines commentary
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally.
HCG mimics LH — it keeps the testes active and producing their own testosterone even while you're taking exogenous testosterone. For fertility, this is critical. For testicular health, it prevents the atrophy that comes with TRT.
250-500 IU every other day if on TRT. Start hCG at the same time as testosterone, not months later when the testes have already atrophied. Monitor estradiol — hCG can raise it significantly due to intratesticular aromatase.
Fuente: Huberman Lab Podcast: Testosterone Optimization (2023)
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Start concurrently with TRT for best results. 250 IU EOD is the minimum dose shown to maintain ITT. 500 IU EOD/3x week is the standard clinical dose. Higher doses increase estradiol — may need aromatase inhibitor.
Higher doses for men seeking testosterone production without exogenous testosterone. Can raise total T by 200-400 ng/dL. Significant estradiol conversion — monitor E2 and manage with AI if needed.
Short-term burst to restore testicular function post-AAS. Taper down over 1-2 weeks. Combine with SERM (clomiphene or tamoxifen) and gonadorelin for full axis recovery. Do not extend high-dose hCG beyond 4 weeks — desensitization risk.
Add 5 mL bacteriostatic water to 5,000 IU vial = 1,000 IU/mL. 500 IU = 50 units (0.5 mL) on insulin syringe. 250 IU = 25 units (0.25 mL). Some prefer 2 mL BAC water for higher concentration.
TRT adjunct: continuous, no cycling needed. PCT use: 2-4 weeks max at high doses, then taper. Chronic high-dose hCG (>3000 IU 3x/week) can desensitize Leydig cell LH receptors — use the minimum effective dose.
Lyophilized: -20°C for 24+ months (but often stored at 2-8°C). Reconstituted: 2-8°C, use within 30-60 days. hCG is a glycoprotein — more robust than small peptides but still requires refrigeration.
Subcutaneous injection into abdomen, thigh, or deltoid. Can be pre-loaded into insulin syringes for convenience. Rotate injection sites.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Leydig Cell Activation & ITT Restoration
- hCG binds LH receptors on Leydig cells within hours of first injection
- Intratesticular testosterone (ITT) begins rising within 24-48 hours
- StAR protein expression upregulated — the rate-limiting step in steroidogenesis
- Testicular volume begins to stabilize (if previously atrophied from TRT)
- Serum testosterone may begin rising within 3-7 days at higher doses
Base de investigación: Coviello et al. (2008) JCEM PMID: 18728176; Roth et al. (2008) PMID: 19056607
Testosterone & Estradiol Stabilization
- Intratesticular testosterone maintained at levels supporting spermatogenesis
- Serum testosterone stabilizes at new steady state (dose-dependent)
- Estradiol rises due to intratesticular aromatase — monitor and manage if symptomatic
- Testicular size normalizes or stabilizes
- Sertoli cell function supported by adequate ITT for ongoing spermatogenesis
Base de investigación: Coviello et al. (2008) PMID: 18728176; Lee & Jarow (2006) PMID: 16952129
Fertility Preservation & Hormonal Optimization
- Semen analysis may show maintained or recovering sperm parameters
- Full spermatogenic cycle is 64-72 days — improvements continue through week 12
- Hormonal milieu stabilized: testosterone maintained, estradiol managed
- In PCT context: transition from hCG to SERM-only as endogenous LH recovers
- In TRT context: continue hCG indefinitely as ongoing adjunct
Base de investigación: Kohn et al. (2017) World Journal of Men's Health PMID: 29282907; spermatogenesis biology
Long-Term Maintenance
- Continued fertility preservation with ongoing TRT + hCG
- Periodic semen analyses recommended every 6-12 months
- Dose adjustments based on testosterone, estradiol, and fertility parameters
- Some men may eventually reduce to 250 IU 2x/week for maintenance
Base de investigación: Long-term TRT clinic protocols; Morgentaler (2008) clinical experience
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
LH Receptor Agonism on Leydig Cells
hCG binds the LH/CG receptor on Leydig cells with the same affinity as LH, activating cAMP/PKA signaling that drives cholesterol import (StAR) and testosterone biosynthesis.
- Shares the alpha subunit with LH — beta subunit confers 24-36 hour half-life (vs 20 min for LH)
- Activates StAR protein — the rate-limiting step for cholesterol transport into mitochondria
- Stimulates the full steroidogenic cascade: cholesterol → pregnenolone → DHEA → androstenedione → testosterone
Matsumoto & Bremner (1985) PMID: 3935269; steroidogenesis textbook biology
Intratesticular Testosterone Maintenance
By maintaining Leydig cell testosterone production, hCG preserves the high intratesticular testosterone concentration (50-100x serum levels) required for Sertoli cell function and spermatogenesis.
- Spermatogenesis requires ITT of 200-600 ng/dL (vs serum levels of 300-1000 ng/dL)
- Exogenous testosterone suppresses LH → ITT drops to near zero → azoospermia in 65% of men
- hCG 250-500 IU EOD maintains ITT at levels sufficient for ongoing spermatogenesis
Coviello et al. (2008) PMID: 18728176; Roth et al. (2008) PMID: 19056607
Testicular Volume & Leydig Cell Preservation
hCG prevents the testicular atrophy that occurs when LH is suppressed by exogenous testosterone, maintaining both Leydig cell mass and overall testicular volume.
- Without LH/hCG stimulation, Leydig cells undergo apoptosis and atrophy within weeks of TRT initiation
- Testicular volume can decrease 20-50% on TRT without hCG
- hCG prevents atrophy and maintains the cellular machinery for endogenous recovery if TRT is discontinued
Lee & Jarow (2006) PMID: 16952129; McBride & Coward (2016) PMID: 27174458
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Low-Dose hCG Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression
Coviello AD, Matsumoto AM, Bremner WJ, et al. — Journal of Clinical Endocrinology & Metabolism (2008)
Hallazgo Clave: Landmark study: 250 IU hCG EOD maintained ITT at 25% of baseline during testosterone-induced gonadotropin suppression (vs near-zero without hCG). 500 IU EOD maintained ITT at 7-fold higher than no-hCG controls.
hCG for the Treatment of Hypogonadism in Males
Lee HY, Jarow JP — Journal of Urology (2006)
Hallazgo Clave: hCG monotherapy (1500-2000 IU 2x/week) increased total testosterone from 211 to 446 ng/dL in hypogonadal men. Testicular volume was preserved and semen parameters maintained.
Clomiphene Citrate and hCG for Restoration of Fertility in Men on Testosterone Therapy
Kohn TP, Louis MR, Pickett SM, et al. — World Journal of Men's Health (2017)
Hallazgo Clave: Men on TRT who added hCG maintained or recovered sperm production. Combined hCG + clomiphene was superior to either alone for fertility restoration in testosterone-treated men.
Exogenous Testosterone Suppresses Spermatogenesis: Efficacy of hCG Co-treatment
Roth MY, Page ST, Lin K, et al. — Journal of Clinical Endocrinology & Metabolism (2008)
Hallazgo Clave: Dose-response study: hCG 125, 250, and 500 IU EOD during testosterone administration. Even 125 IU EOD partially maintained spermatogenesis. 500 IU EOD provided robust sperm count preservation.
Human Chorionic Gonadotropin: Profiles of Use and Effects on Spermatogenesis
McBride JA, Coward RM — Urology Clinics of North America (2016)
Hallazgo Clave: Comprehensive review: hCG maintains Leydig cell function, ITT, and spermatogenesis during TRT. Recommended as standard co-treatment for all men on testosterone who may desire future fertility.
Effects of hCG on Testosterone Secretion and Testicular Histology in Men
Matsumoto AM, Bremner WJ — Journal of Clinical Endocrinology & Metabolism (1985)
Hallazgo Clave: Classic study: hCG 5000 IU 3x/week for 12 weeks increased testosterone to supraphysiological levels. Leydig cell hyperplasia documented histologically. Established dose-response relationship for hCG-testosterone.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar HCG con estos péptidos para mecanismos complementarios.
Gonadorelin re-establishes the hypothalamic GnRH signal while hCG directly supports Leydig cells — dual-level HPG axis restoration.
The most comprehensive HPG axis recovery approach: gonadorelin restores the signal from above while hCG maintains gonadal function from below. Foundation of advanced PCT protocols.
Kisspeptin drives endogenous GnRH → LH pulses while hCG provides sustained LH-like gonadal support — covering the full HPG cascade.
Combines physiological HPG axis stimulation (kisspeptin) with pharmacological gonadal support (hCG) — particularly useful in IVF/fertility treatment contexts.
hCG provides LH-like activity while HMG provides both FSH and LH — adding FSH stimulation that hCG alone cannot provide.
Comprehensive gonadotropin replacement: hCG for reliable testosterone production, HMG adds FSH for direct spermatogenesis support. Used in severe hypogonadotropic hypogonadism.
Single low-dose triptorelin for acute LH surge, followed by hCG for sustained gonadal support — a sequential PCT strategy.
Triptorelin provides the initial hormonal 'kickstart' while hCG maintains testicular function throughout recovery. A rapid-onset PCT strategy.
Especificaciones
Cómo Funciona HCG
HCG is a glycoprotein hormone that shares structural homology with luteinizing hormone (LH) and binds to the same LH/CG receptor (LHCGR). In males, it stimulates Leydig cells to produce testosterone, maintaining testicular size and function. In females, it triggers ovulation and supports corpus luteum progesterone production. The extensive glycosylation (including sialic acid residues) dramatically extends its half-life compared to LH. HCG is used to maintain endogenous testosterone production during exogenous hormone therapy.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
1000iu | $30.00 | $255.00 |
2000iu | $40.00 | $340.00 |
5000iu | $70.00 | $595.00 |
10000iuMejor Valor | $120.00 | $1020.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Estradiol elevation — gynecomastia risk
hCG stimulates intratesticular aromatase, which can significantly raise estradiol. Monitor E2 levels regularly. If E2 rises above 40-50 pg/mL with symptoms, consider low-dose aromatase inhibitor. Gynecomastia risk increases with higher hCG doses.
Leydig cell desensitization at high doses
Chronic high-dose hCG (>5000 IU 3x/week) can desensitize Leydig cell LH receptors and paradoxically reduce testosterone production. Use the minimum effective dose. Standard TRT adjunct: 250-500 IU EOD.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
Péptidos Relacionados
Up to 37% OffPT141
Estudiado para vías de excitación centrales impulsadas por melanocortina
Melanotan I
Estudiado para la activación del receptor melanocortina-1 y melanogénesis
Up to 30% OffMelanotan II
Agonista de melanocortina multi-receptor estudiado para diversas vías
Up to 29% OffKisspeptin-10
Estudiado para la modulación del eje HPG y pulsatilidad de GnRH