Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Gonadorelin Acetate
CAS: 33515-09-2 (free base); 34973-08-5 (acetate)
Estudiado para la restauración natural de gonadotropinas post-supresión
Gonadorelin Acetate is a research peptide in the sexual health / hormonal category. Gonadorelin is the synthetic form of endogenous gonadotropin-releasing hormone (GnRH), a decapeptide produced by hypothalamic GnRH neurons. MiPeptidos offers Gonadorelin Acetate in 2 sizes with 99.5% verified purity and full analytical documentation.
- Supports natural testosterone
- Maintains fertility on TRT
- Preserves testicular function
- Mimics your body's own signal
Research suggests LH and FSH levels respond within hours of pulsatile use. Over weeks 1-4, studies report gradual improvements in energy and hormonal markers. By weeks 6-8, the pulsatile protocol supports sustained HPG axis activity, with measurable improvements in testosterone and gonadal function.
$17.95/vial · Everything you need to start
Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Reclaim Your Axis.
8-week GnRH pulsatile protocol used clinically for HPG axis assessment and restoration
Gonadorelin acetate is a synthetic decapeptide identical to naturally occurring gonadotropin-releasing hormone (GnRH). It is the physiological signal that drives the entire reproductive hormone cascade: pulsatile GnRH release from the hypothalamus stimulates LH and FSH secretion from the anterior pituitary, which in turn drives gonadal steroidogenesis and gametogenesis.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. William Crowley
Professor of Medicine, Harvard Medical School / MGH
Pioneer of pulsatile GnRH therapy. Led the development and clinical trials of Lutrepulse (pulsatile gonadorelin). Director of the Reproductive Endocrine Unit at Massachusetts General Hospital.
Pulsatile GnRH administration is the most physiological way to restore reproductive function. Every 90-120 minutes, the hypothalamus releases GnRH in a pulse — and when we replicate that pattern, we can restore fertility in patients with hypothalamic failure.
Pulsatile SC: 25-200 ng/kg per pulse every 90-120 minutes. SC pulse dose: 5-20 mcg per pulse. For diagnostic testing: 100 mcg SC bolus, measure LH at 15, 30, 60, 90 min.
Fuente: Crowley et al. (1985) NEJM; Lutrepulse FDA labeling; multiple MGH publications
Dr. Robert Barbieri
Chair of OB/GYN, Brigham and Women's Hospital, Harvard Medical School
Kate Macy Ladd Distinguished Professor at Harvard. Leading authority on reproductive endocrinology. Editor of OBG Management. Expert on GnRH pharmacology.
The distinction between pulsatile and continuous GnRH is the most important concept in reproductive neuroendocrinology. Pulsatile activates; continuous suppresses. This single principle underlies both fertility treatment and cancer therapy.
Diagnostic use: 100 mcg SC bolus. Therapeutic pulsatile use: 5-25 mcg SC per pulse every 90-120 min. For TRT-related HPG recovery: begin pulsatile protocol 2-4 weeks after testosterone discontinuation.
Fuente: Barbieri (1992) Clinical Obstetrics and Gynecology; MGH Reproductive Endocrine protocols
Dr. Ali Abbara
Clinical Senior Lecturer, Imperial College London
Expert in kisspeptin and GnRH physiology. Led clinical trials on kisspeptin-triggered IVF and GnRH pulse protocols. Co-investigator on multiple JCEM and Lancet publications.
The GnRH pulse frequency is the hormonal language of the reproductive axis. High-frequency pulses favor LH; low-frequency pulses favor FSH. By modulating pulse frequency, we can fine-tune the gonadotropin profile to clinical need.
SC pulsatile dosing is the preferred approach. Optimal pulse frequency: every 90 min for balanced LH:FSH, every 60 min for LH-dominant, every 180-240 min for FSH-dominant stimulation.
Fuente: Abbara et al. (2018) Journal of Clinical Investigation; Imperial College GnRH protocols
Dr. Michael Scally
Physician, Houston Wellness Clinic
Developer of the 'Power PCT' protocol for anabolic steroid-induced hypogonadism recovery. Specialist in HPTA (hypothalamic-pituitary-testicular axis) restoration.
Gonadorelin is essential for post-cycle recovery. It re-establishes the GnRH signal that steroids suppress. Without restoring the hypothalamic signal, you're relying on downstream agents alone — and that's incomplete recovery.
PCT protocol: Gonadorelin 100 mcg SC twice daily (mimicking pulsatile release) for 4-8 weeks alongside hCG and a SERM. Begin 2 weeks after last testosterone injection.
Fuente: Scally (2009) Hormone Molecular Biology and Clinical Investigation; PCT protocol publications
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
GnRH stimulation test: measure LH at baseline, 15, 30, 60, 90 minutes post-injection. Normal response: LH rises 2-5x baseline. Blunted response suggests pituitary dysfunction; exaggerated response suggests hypothalamic origin.
True pulsatile protocol requires an infusion pump or disciplined manual injection schedule. Simplified: 100 mcg SC twice daily (morning + evening) approximates pulsatile pattern. Monitor LH, FSH, testosterone at weeks 2 and 4.
Continue until HPG axis labs normalize. Reassess every 2-4 weeks. In PCT context: combine with hCG (weeks 1-4) and SERM (weeks 1-8). Taper gonadorelin before discontinuing.
Add 1 mL bacteriostatic water to 2 mg vial = 2 mg/mL (2,000 mcg/mL). 100 mcg = 5 units on insulin syringe; 50 mcg = 2.5 units.
Gonadorelin is used therapeutically, not cycled. Pulsatile use can continue for 8-16 weeks. CRITICAL: Avoid continuous infusion — continuous GnRH causes receptor downregulation and paradoxical suppression (the same mechanism as leuprolide/triptorelin depot).
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 14 days (short stability due to small peptide size). Prepare fresh vials every 2 weeks.
Subcutaneous injection. Very short half-life (2-4 minutes) means each dose acts as a discrete pulse. For true pulsatile therapy: program infusion pump for 90-120 min intervals. Simplified protocols use 2x daily manual injections.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Acute GnRH Stimulation Test
- GnRH binds pituitary GnRH-R within seconds — rapid receptor activation
- LH release begins within 15 minutes, peaks at 30-45 minutes
- FSH rise is more modest and slower (peaks at 60-90 minutes)
- Normal LH response: 2-5x baseline increase
- Flat response indicates pituitary failure; exaggerated response suggests hypothalamic dysfunction
Base de investigación: Factrel FDA labeling; Crowley et al. (1985) NEJM; standard GnRH stimulation test protocols
HPG Axis Re-Engagement
- Pulsatile dosing re-establishes GnRH signaling to pituitary gonadotropes
- LH and FSH begin to normalize if the pituitary is functional
- In hypogonadal men: testosterone may begin rising by week 2
- Pituitary GnRH receptor density normalizes (recovery from any prior desensitization)
- FSH:LH ratio adjusts based on pulse frequency used
Base de investigación: Crowley et al. (1985) NEJM PMID: 3969120; Lutrepulse clinical data
Gonadotropin & Steroid Recovery
- LH and FSH approach or reach normal physiological ranges
- Testosterone (males) or estradiol (females) progressively normalizes
- In PCT context: synergy with hCG and SERM amplifies recovery
- Spermatogenesis re-initiation (FSH-driven) — full recovery takes 3-6 months
- Symptomatic improvement: energy, libido, mood begin to recover with rising sex steroids
Base de investigación: Scally (2009) HMBC&I; hypothalamic amenorrhea pulsatile GnRH trials
Axis Stabilization & Protocol Completion
- Repeat comprehensive hormone panel: LH, FSH, total/free testosterone, estradiol, SHBG
- If labs are normal: taper gonadorelin over 1-2 weeks before discontinuing
- If labs remain suppressed: extend protocol or escalate to hCG-based approach
- Natural GnRH pulsatility should resume once exogenous support is withdrawn
Base de investigación: General reproductive endocrinology principles; PCT outcome data
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
GnRH Receptor Activation on Pituitary Gonadotropes
Gonadorelin binds GnRH-R (a Gq-coupled GPCR) on anterior pituitary gonadotropes, triggering IP3/DAG signaling that releases stored LH and FSH from secretory granules.
- GnRH-R is uniquely designed for pulsatile signaling — lacks the C-terminal tail that enables rapid desensitization
- Each GnRH pulse produces a discrete LH/FSH release event
- Continuous stimulation overwhelms this design → receptor internalization → gonadotropin suppression
Belchetz et al. (1978) PMID: 100883; Millar et al. (2004) Endocrine Reviews
Pulse Frequency-Dependent LH:FSH Modulation
The frequency of GnRH pulses determines the ratio of LH to FSH released, enabling fine-tuned control of gonadal function through temporal signaling patterns.
- Fast pulses (60 min) → preferential LH secretion → testosterone production
- Slow pulses (180-240 min) → preferential FSH secretion → spermatogenesis / folliculogenesis
- Normal physiological frequency: 90-120 min → balanced LH:FSH ratio
Spratt et al. (1987) PMID: 3116030
HPG Axis Restoration After Suppression
Pulsatile gonadorelin re-establishes hypothalamic-pituitary communication that was disrupted by exogenous hormones (TRT, AAS) or hypothalamic dysfunction.
- Exogenous testosterone suppresses endogenous GnRH via negative feedback
- Pulsatile gonadorelin bypasses the suppressed hypothalamus, directly reactivating the pituitary
- Combined with hCG (gonadal support) and SERMs (anti-estrogen feedback), enables systematic axis restoration
Scally (2009) PMID: 25961215; Crowley et al. (1985) PMID: 3969120
Investigación Publicada
5 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Induction of Puberty in the Hypogonadal Female by Pulsatile Administration of GnRH
Crowley WF, Filicori M, Spratt DI, Santoro NF — New England Journal of Medicine (1985)
Hallazgo Clave: Pulsatile GnRH (every 90-120 min via infusion pump) successfully induced puberty, ovulation, and pregnancy in women with hypothalamic hypogonadism — proving that pulsatile pattern is critical.
GnRH Pulse Frequency and LH/FSH Secretion in Humans
Spratt DI, Finkelstein JS, Butler JP, et al. — Journal of Clinical Endocrinology & Metabolism (1987)
Hallazgo Clave: Demonstrated that GnRH pulse frequency directly determines LH:FSH ratio. Faster pulses (every 60 min) favor LH; slower pulses (every 180+ min) favor FSH. This is the basis for frequency-tuned gonadotropin modulation.
Continuous vs Pulsatile GnRH: Differential Effects on Gonadotropin Secretion
Belchetz PE, Plant TM, Nakai Y, et al. — Science (1978)
Hallazgo Clave: Landmark primate study: continuous GnRH infusion causes paradoxical gonadotropin suppression (receptor downregulation), while pulsatile GnRH maintains normal LH/FSH secretion. This discovery underlies all GnRH agonist drug design.
Anabolic Steroid-Induced Hypogonadism: Diagnosis and Treatment
Scally MC — Hormone Molecular Biology and Clinical Investigation (2009)
Hallazgo Clave: Defined ASIH (anabolic steroid-induced hypogonadism) as a clinical entity. Proposed multi-drug PCT including pulsatile GnRH, hCG, and SERMs for systematic HPG axis restoration.
Factrel (Gonadorelin) for Diagnostic Evaluation of Hypothalamic-Pituitary Gonadotropic Function
Ayala-Torres S, Rosen SW, Snyder PJ — Journal of Clinical Endocrinology & Metabolism (1977)
Hallazgo Clave: Established the GnRH stimulation test protocol: 100 mcg IV bolus with LH sampling at 15, 30, 60, 90 min. Normal response: LH increases 2-5x baseline. Became the standard diagnostic tool for pituitary-gonadal assessment.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Gonadorelin Acetate con estos péptidos para mecanismos complementarios.
Gonadorelin restores the hypothalamic GnRH signal while HCG directly stimulates Leydig cells — covering both levels of the HPG axis.
The gold standard PCT combination: gonadorelin re-establishes the hypothalamic signal while HCG prevents testicular atrophy and maintains testosterone production during axis recovery.
Kisspeptin acts upstream of GnRH neurons while gonadorelin acts at the pituitary — together they activate the entire HPG cascade from top to bottom.
Maximum HPG axis stimulation from hypothalamic kisspeptin neurons all the way down to gonadal steroidogenesis. Useful for severe axis suppression.
Low-dose triptorelin can produce an acute LH/FSH surge to jumpstart recovery, followed by gonadorelin for sustained pulsatile maintenance.
Sequential approach: triptorelin for acute axis kickstart, then transition to gonadorelin for physiological pulsatile maintenance. Avoids triptorelin's desensitization risk with single-dose use.
Gonadorelin restores the hormonal substrate (testosterone) while PT-141 provides acute central arousal enhancement — addressing both causes of libido loss.
Comprehensive libido restoration: gonadorelin rebuilds the hormonal base while PT-141 activates desire circuitry — critical when low libido has both hormonal and central components.
Especificaciones
Cómo Funciona Gonadorelin Acetate
Gonadorelin is the synthetic form of endogenous gonadotropin-releasing hormone (GnRH), a decapeptide produced by hypothalamic GnRH neurons. It binds to GnRH receptors (GnRHR) on anterior pituitary gonadotroph cells, triggering release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Pulsatile administration stimulates the reproductive axis, while continuous administration paradoxically downregulates it through receptor desensitization. This dual action makes it useful for both stimulation and suppression.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
2mgOferta | $24.95$30.00 | $212.07 | 17% descuento |
5mgMejor Valor | $76.95 | $65.95 | — |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Continuous use causes paradoxical suppression
Continuous (non-pulsatile) GnRH administration causes GnRH receptor downregulation and gonadotropin suppression — the exact opposite of the intended effect. This is the mechanism behind GnRH agonist drugs. Maintain pulsatile dosing pattern.
Not for use in hormone-sensitive cancers
GnRH stimulation increases sex steroid production. Contraindicated in prostate cancer, breast cancer, or other hormone-receptor-positive malignancies unless specifically using continuous dosing for suppression under medical supervision.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
Péptidos Relacionados
Up to 37% OffPT141
Estudiado para vías de excitación centrales impulsadas por melanocortina
Melanotan I
Estudiado para la activación del receptor melanocortina-1 y melanogénesis
Up to 30% OffMelanotan II
Agonista de melanocortina multi-receptor estudiado para diversas vías
Up to 29% OffKisspeptin-10
Estudiado para la modulación del eje HPG y pulsatilidad de GnRH