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Análisis de Pureza HPLC
FST 344
CAS: 80449-31-6
Estudiado para la señalización de crecimiento muscular mediada por IGF-1
FST 344 is a research peptide in the specialty / research category. Follistatin 344 is the full-length isoform of follistatin, a secreted glycoprotein that acts as a potent antagonist of activin, myostatin (GDF-8), and other TGF-beta superfamily ligands. MiPeptidos offers FST 344 in 1 sizes with 99.4% verified purity and full analytical documentation.
- Rapid muscle fullness
- Noticeable strength gains
- Improved body composition
- Enhanced workout recovery
During week 1, research suggests myostatin suppression begins within 24 hours, with studies reporting enhanced muscle pump and faster recovery. By weeks 2-3, studies show peak muscle response as satellite cells activate, bringing noticeable strength gains, visible muscle fullness, and improved training capacity. Week 4 consolidates gains, with research indicating muscle built during the protocol is retained when training continues.
$59.09/vial · Everything you need to start
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Análisis de Pureza HPLC
Unlock Muscle Growth.
4-week myostatin inhibition protocol backed by gene therapy research and muscle biology studies
Follistatin-344 (FST-344) is the full-length isoform of follistatin, a naturally occurring glycoprotein that functions as a potent inhibitor of myostatin (GDF-8), activin, and other TGF-β superfamily members that limit muscle growth. By binding to and neutralizing myostatin — the primary negative regulator of skeletal muscle mass — follistatin effectively removes the biological brake on muscle growth.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
2 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Se-Jin Lee
Professor of Genetics and Molecular Biology, Johns Hopkins/Jackson Laboratory
Discoverer of myostatin (GDF-8) in 1997. His foundational work established the myostatin-follistatin axis as the primary regulator of skeletal muscle mass.
Follistatin is the most potent naturally occurring myostatin inhibitor. Its ability to bind and neutralize not just myostatin but also activin creates a comprehensive de-repression of muscle growth that is unmatched by single-target approaches.
Research protocols should be designed with careful attention to dosing intervals. Follistatin has a relatively short half-life requiring frequent administration or depot formulations.
Fuente: Nature (1997); PNAS (2001); Cell (2010)
Dr. Brian Kaspar
Gene Therapy Researcher (Nationwide Children's Hospital)
Led the first human clinical trials of follistatin gene therapy for Becker muscular dystrophy (AAV-FS344). Established safety and efficacy of follistatin overexpression in humans.
Our AAV-follistatin trials proved that sustained myostatin inhibition in humans is safe and leads to measurable improvements in muscle function. The results opened the door for follistatin-based therapeutics.
Gene therapy trials used FST-344 delivered to specific muscle groups. Systemic peptide approaches require regular dosing due to follistatin's relatively short circulating half-life.
Fuente: Molecular Therapy (2015); Molecular Therapy Methods & Clinical Development (2017)
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Reconstitute 1mg in 1mL bac water. Each 0.1mL = 100mcg. Daily dosing needed due to short half-life. Inject at consistent time.
Continue daily administration. Myostatin suppression requires sustained follistatin levels. Combine with resistance training for maximum effect.
Gradual reduction allows natural myostatin signaling to resume. Abrupt cessation is also acceptable.
Reconstitute 1mg vial with 1mL bacteriostatic water for 1mg/mL concentration (100mcg per 0.1mL). Swirl gently. Solution should be clear.
4 weeks on, 4-8 weeks off. Extended use beyond 4 weeks has not been well-studied. The short cycle minimizes potential effects on other TGF-β pathways.
Lyophilized: -20°C long-term, 2-8°C short-term. Reconstituted: 2-8°C, use within 14 days. Follistatin is more fragile than many peptides — handle carefully.
Insulin syringe (29-31 gauge), subcutaneous. Rotate injection sites. Administer at the same time daily for consistent blood levels. Best combined with strength training.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Myostatin Suppression Initiation
- Increased workout recovery capacity
- Enhanced muscle pump during training
- Subtle strength improvements noted
- Appetite increase common
Base de investigación: Follistatin begins suppressing circulating myostatin within 24 hours, but tissue-level effects require 5-7 days to manifest (Lee et al., 2001).
Muscle Response Activation
- Noticeable strength gains in primary lifts
- Improved muscle fullness
- Enhanced exercise tolerance
- Body composition beginning to shift
Base de investigación: Satellite cell activation and myogenic signaling increase once myostatin suppression is sustained beyond 7 days.
Peak Muscle Growth Phase
- Measurable strength increases across all movements
- Visible muscle fullness and vascularity
- Improved training volume capacity
- Body weight increase (lean mass)
Base de investigación: Gene therapy studies show peak muscle response at 2-3 weeks of sustained follistatin exposure (Kaspar et al., 2015).
Consolidation & Taper
- Strength gains consolidating
- Muscle mass maintained with proper training
- Gradual return of natural myostatin signaling
- Training adaptations persist post-protocol
Base de investigación: Myostatin-induced muscle gains are partially retained after follistatin cessation if training stimulus is maintained.
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
Myostatin Sequestration
Follistatin binds directly to myostatin (GDF-8) with high affinity, preventing it from activating ActRIIB receptors on muscle cells. This removes the primary biological brake on muscle growth.
- High-affinity binding neutralizes circulating myostatin
- Also binds activin A and GDF-11 for additional growth de-repression
- Enables satellite cell activation and myogenic differentiation
- Effect is dose-dependent and reversible upon cessation
McPherron et al., Nature (1997); Lee & McPherron, PNAS (2001)
Satellite Cell Activation
With myostatin suppressed, quiescent muscle satellite cells are activated, proliferate, and fuse with existing muscle fibers to increase cross-sectional area (hypertrophy) and potentially fiber number (hyperplasia).
- Myostatin normally keeps satellite cells quiescent
- Follistatin removes this suppression, enabling proliferation
- Activated satellite cells donate nuclei to muscle fibers
- More nuclei per fiber increases protein synthesis capacity
Kota et al., Sci Transl Med (2009)
TGF-β Superfamily Modulation
Beyond myostatin, follistatin neutralizes activin A and other TGF-β family members that inhibit tissue growth, creating a broadly permissive environment for anabolic processes.
- Activin A inhibition reduces muscle atrophy signaling
- GDF-11 neutralization may improve regenerative capacity
- Broad TGF-β suppression shifts balance toward growth
- Explains why follistatin exceeds myostatin-only inhibition
Lee & McPherron, PNAS (2001)
Investigación Publicada
4 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member
McPherron AC, Lawler AM, Lee SJ — Nature (1997)
Hallazgo Clave: Discovery of myostatin (GDF-8) as the primary negative regulator of muscle mass. Myostatin knockout mice showed 2-3x normal muscle mass.
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates
Kota J, Handy CR, Haidet AM, et al. — Science Translational Medicine (2009)
Hallazgo Clave: AAV-delivered follistatin increased muscle mass and strength in cynomolgus macaques with no adverse effects.
Follistatin gene therapy for Becker muscular dystrophy
Mendell JR, Sahenk Z, Malik V, et al. — Molecular Therapy (2015)
Hallazgo Clave: First human trial of follistatin gene therapy showed improved 6-minute walk distance and no serious adverse events in Becker MD patients.
Regulation of myostatin activity and muscle growth
Lee SJ, McPherron AC — Proceedings of the National Academy of Sciences (2001)
Hallazgo Clave: Follistatin overexpression produced greater muscle mass increase than myostatin knockout alone, suggesting it inhibits additional TGF-β ligands limiting growth.
Potencia tu Protocolo de Investigación
3 SinergiasLa investigación sugiere combinar FST 344 con estos péptidos para mecanismos complementarios.
IGF-1 provides the anabolic signaling that follistatin's myostatin removal enables
Maximum muscle growth potential with both negative regulators removed and positive growth signals amplified.
Growth hormone amplifies the anabolic environment for muscle growth
Enhanced lean mass gains with improved recovery, sleep quality, and body composition optimization.
ACE-031 provides additional myostatin trap via a different mechanism
Comprehensive myostatin blockade through two independent mechanisms for maximum muscle growth de-repression.
Especificaciones
Cómo Funciona FST 344
Follistatin 344 is the full-length isoform of follistatin, a secreted glycoprotein that acts as a potent antagonist of activin, myostatin (GDF-8), and other TGF-beta superfamily ligands. It binds these ligands with high affinity, preventing their interaction with cell-surface receptors and neutralizing their biological activity. By inhibiting myostatin, FST-344 removes the major endogenous brake on muscle growth, leading to increased muscle mass (muscle hypertrophy). The 344-isoform has lower heparin affinity than FST-288, giving it broader systemic distribution.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
1mg | $140.00 | $1190.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Experimental research compound
FST-344 is sold strictly for research purposes. While gene therapy trials have shown safety, injectable peptide follistatin has not undergone clinical trials. Dosing is extrapolated from preclinical research.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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