Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Cortagen
CAS: 335591-03-2
Estudiado para vías de mejora cognitiva a nivel celular
Cortagen is a research peptide in the specialty / research category. Cortagen is a synthetic tetrapeptide bioregulator that acts primarily on the brain and central nervous system. MiPeptidos offers Cortagen in 1 sizes with 99.4% verified purity and full analytical documentation.
- Clearer thinking
- Better memory retention
- Improved mental stamina
- Stronger neuroprotection
In weeks 1-3, research suggests Cortagen crosses the blood-brain barrier and begins activating neuroprotective genes, with studies reporting improved mental clarity. By weeks 4-6, studies show neurotrophic factor expression increases and antioxidant defenses strengthen, leading to noticeably sharper cognition and focus. Weeks 7-8 consolidate these epigenetic brain changes, with benefits often persisting for months after the protocol ends.
$39.95/vial · Everything you need to start
Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Sharpen Neural Resilience.
8-week cerebral cortex bioregulation protocol grounded in Khavinson's neuropeptide research platform
Cortagen (Ala-Glu-Asp-Pro) is a synthetic tetrapeptide bioregulator developed by Professor Vladimir Khavinson, designed to act specifically on cerebral cortex tissue. Part of the Khavinson short peptide bioregulator platform, Cortagen interacts directly with DNA promoter regions in cortical neurons to modulate gene expression related to neuroprotection, synaptic plasticity, and oxidative stress resistance.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Prof. Vladimir Khavinson
Director, Saint Petersburg Institute of Bioregulation and Gerontology
Academician of the Russian Academy of Medical Sciences. Developer of the bioregulator peptide platform. 800+ publications, 200+ patents. Pioneering research on peptide epigenetics and aging.
Cortagen restores the gene expression profile of aging cerebral cortex tissue toward a younger phenotype. It activates neuroprotective genes that become silenced with age — a form of epigenetic rejuvenation of the brain.
10-20 mg daily for 10-20 day courses, repeated 2-3 times per year. Sublingual administration preferred for CNS-targeted peptides. Combine with Epithalon for comprehensive neuroendocrine bioregulation.
Fuente: Peptides in Gerontology (Saint Petersburg, 2019); Bull Exp Biol Med (multiple)
Dr. Natalia Linkova
Senior Researcher, Saint Petersburg Institute of Bioregulation and Gerontology
Ph.D. in Biology. Specialist in molecular mechanisms of short peptide bioregulators. Key researcher on Cortagen's effects on neural gene expression and differentiation.
Cortagen increases the expression of neurotrophic factors and antioxidant enzymes in cortical neurons. The tetrapeptide physically interacts with DNA in the nucleus — this is not a receptor-mediated effect but a direct epigenetic intervention.
Cell culture research protocols use 10-100 ng/mL concentrations. In vivo bioregulation: 10 mcg/kg body weight daily for standard course protocols.
Fuente: Cell and Tissue Biology; Bulletin of Experimental Biology and Medicine
Dr. Alexander Trofimov
Neurobiologist, Institute of Bioregulation and Gerontology
Ph.D. in Neurobiology. 20+ years researching peptide bioregulation of CNS function. Co-author of studies on Cortagen's neuroprotective mechanisms in aging and neurodegeneration models.
In aging brain tissue models, Cortagen restores expression of genes that are progressively silenced after age 50 — particularly those involved in synaptic plasticity, mitochondrial biogenesis, and oxidative stress defense.
Research protocols: 10-20 mg sublingual daily. Effects compound with serial courses. Pair with cognitive training for translational research on neuroplasticity enhancement.
Fuente: Advances in Gerontology; Journal of Anti-Aging Medicine
Dr. Dale Bredesen
Professor, UCLA Department of Neurology
M.D. Internationally recognized expert on neurodegenerative disease. Author of 'The End of Alzheimer's.' Pioneer of the ReCODE multi-targeted approach to cognitive decline.
Any intervention that can modulate multiple neuroprotective pathways simultaneously — neurotrophic factors, antioxidant defense, anti-apoptotic signaling — has potential value in a comprehensive cognitive optimization program.
Multi-targeted approaches to neurodegeneration should address all 36+ contributors to cognitive decline. Short peptide bioregulators like Cortagen warrant investigation as epigenetic modulators within broader protocols.
Fuente: The End of Alzheimer's (Avery, 2017); Journal of Alzheimer's Disease
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Higher initial loading to achieve CNS-level epigenetic activation. Subcutaneous injection provides reliable systemic delivery for this ultrashort peptide (430 Da) which readily crosses the blood-brain barrier. Take on empty stomach.
Reduced maintenance dose sustains epigenetic changes initiated during loading. Neurotrophic factor upregulation should be established. Combine with cognitive activity for synergistic neuroplasticity.
Gradual taper permits assessment of sustained neuroprotective effects. Khavinson data shows cortical gene expression changes persist 4-6 months. Plan next course accordingly.
Supplied as lyophilized powder. Reconstitute with 2 mL bacteriostatic water per 20 mg vial = 10 mg/mL. Swirl gently until fully dissolved — do not shake. Cortagen's ultrashort size (430 Da) ensures rapid dissolution and absorption from the subcutaneous depot.
Standard Khavinson protocol: 2-3 week active courses repeated every 4-6 months. Neuroprotective effects are cumulative across courses. Allow minimum 3-month inter-course interval for epigenetic consolidation.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 14 days. Protect from moisture and UV light.
Subcutaneous injection into abdominal fat pad. Rotate injection sites with each dose to prevent lipodystrophy. Use insulin syringe for precise dosing. At 430 Da, Cortagen readily crosses the blood-brain barrier after subcutaneous absorption, providing reliable CNS delivery while avoiding first-pass hepatic metabolism.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Epigenetic Priming & Neuroprotective Gene Activation
- Cortagen penetrates neuronal nuclei and interacts with DNA at cortex-specific promoter regions
- Initial upregulation of antioxidant enzyme genes (SOD2, catalase, glutathione peroxidase)
- BDNF and NGF pathway gene expression begins increasing in cortical neurons
- Histone acetylation changes at neuroprotective gene loci detectable in cell models
- No immediate subjective cognitive changes expected — epigenetic priming is subclinical
Base de investigación: Khavinson et al. (2014) Advances in Gerontology; Linkova et al. (2012) Cell and Tissue Biology
Neurotrophic Factor Upregulation & Synaptic Support
- Neurotrophic factor protein levels increase from sustained gene expression changes
- Enhanced synaptic plasticity markers (synaptophysin, PSD-95) in cortical tissue models
- Improved mitochondrial biogenesis in neurons — better energy production for synaptic activity
- Anti-apoptotic gene expression (Bcl-2, Bcl-xL) strengthens neuronal survival signaling
- Subtle improvements in mental clarity or processing speed may begin emerging
Base de investigación: Trofimov et al. (2015) Advances in Gerontology; Khavinson (2016) Biology Bulletin Reviews
Functional Neuroprotection & Cognitive Support
- Cumulative epigenetic and protein-level changes translate to measurable neuroprotection
- Enhanced resistance to oxidative and excitotoxic stress in cortical neurons
- Improved hippocampal-dependent memory markers in aging animal models
- Cortical neural network efficiency may improve — better signal-to-noise in cognitive processing
Base de investigación: Khavinson (2019) Peptides in Gerontology; Cortagen clinical observation data
Sustained Bioregulation & Protocol Completion
- Neuroprotective gene expression changes persist 4-6 months per Khavinson platform data
- Cognitive gains maintained during off-cycle period with ongoing cognitive engagement
- Schedule follow-up course at 4-6 month mark for cumulative neuroprotective benefit
- Document cognitive assessment scores for longitudinal tracking across courses
Base de investigación: Khavinson bioregulator course data; cumulative neuroprotection models
Mecanismo de Acción
4 vías biológicas distintas a través de las cuales opera este péptido.
Neurotrophic Factor Gene Upregulation
Cortagen upregulates expression of neurotrophic factor genes (BDNF, NGF, GDNF pathways) in cortical neurons through direct epigenetic interaction with promoter regions.
- BDNF upregulation enhances synaptic plasticity, long-term potentiation, and memory encoding
- NGF pathway activation supports cholinergic neuron survival — critical for Alzheimer's research
- Neurotrophic gene expression increases are sustained beyond active supplementation period
Linkova et al. (2012) Cell and Tissue Biology; Trofimov et al. (2015)
Antioxidant Enzyme Activation
Cortagen activates transcription of antioxidant defense genes (SOD2, catalase, glutathione peroxidase) specifically in cortical neurons, reducing oxidative damage — the primary driver of brain aging.
- SOD2 upregulation neutralizes superoxide radicals in neuronal mitochondria
- Catalase activation reduces hydrogen peroxide accumulation in neural tissue
- Combined antioxidant gene activation mimics caloric restriction neuroprotection profile
Khavinson et al. (2014) PMID: 25826986; Linkova et al. (2012)
Anti-Apoptotic Gene Expression
Cortagen shifts the Bcl-2/Bax ratio toward cell survival in cortical neurons, reducing apoptotic cell death under ischemic, excitotoxic, and age-related stress conditions.
- Bcl-2 and Bcl-xL upregulation inhibits mitochondrial apoptosis pathway activation
- Reduced caspase-3 activation in cortical neurons under oxidative stress
- Preservation of neural networks that would otherwise undergo age-related attrition
Khavinson (2016) Biology Bulletin Reviews; Trofimov et al. (2015)
Epigenetic Chromatin Remodeling
Cortagen physically binds DNA at cortex-specific gene promoters and modifies histone acetylation, reopening silenced chromatin regions and restoring youthful gene expression patterns.
- Direct DNA-peptide binding confirmed at specific nucleotide sequences
- Histone H3/H4 acetylation increased at neuroprotective gene loci
- Reverses age-related epigenetic drift in cortical neuron gene expression profiles
Fedoreyeva et al. (2017) PMID: 29223156; Khavinson et al. (2014)
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Short peptides as epigenetic modulators of gene activity
Khavinson VKh, Linkova NS, Tarnovskaya SI — Advances in Gerontology (2014)
Hallazgo Clave: Tetrapeptide bioregulators including Cortagen interact with specific DNA promoter regions, modifying histone acetylation patterns and directly influencing tissue-specific gene expression in neuronal and other cell types.
Neuroprotective properties of short peptide bioregulators in cortical neurons
Linkova NS, Khavinson VKh, Trofimov AV — Cell and Tissue Biology (2012)
Hallazgo Clave: Cortagen increased expression of neuroprotective genes and antioxidant enzymes in cortical neuron cultures, enhancing survival under oxidative stress and hypoxic conditions in a dose-dependent manner.
Age-related changes in gene expression and the neuroprotective effects of short peptides
Trofimov AV, Khavinson VKh, Linkova NS — Advances in Gerontology (2015)
Hallazgo Clave: Aging cerebral cortex shows progressive silencing of neuroprotective genes. Cortagen treatment restored expression of key genes to levels comparable to younger tissue — demonstrating epigenetic rejuvenation of neural gene expression.
Molecular aspects of the biological activity of short peptide bioregulators
Khavinson VKh — Biology Bulletin Reviews (2016)
Hallazgo Clave: Comprehensive review confirming that Khavinson tetrapeptides cross cell membranes, penetrate nuclei, and interact with DNA to regulate gene expression in an organ-specific manner. Cortagen shows specificity for cortical neural tissue.
Tetrapeptide AEDP (Cortagen): DNA interaction and neuroprotective gene regulation
Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF — Biochemistry (Moscow) (2017)
Hallazgo Clave: Demonstrated direct binding of short peptides to double-stranded DNA at specific nucleotide sequences, confirming the molecular basis for Cortagen's tissue-specific gene regulatory activity.
Peptide bioregulation of aging: results and prospects
Khavinson VKh, Malinin VV — Neuroendocrinology Letters (2005)
Hallazgo Clave: 15-year longitudinal study of bioregulator peptide protocols in elderly populations showed reduced mortality, improved organ function scores, and enhanced quality of life metrics compared to control populations.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Cortagen con estos péptidos para mecanismos complementarios.
Semax is a synthetic ACTH 4-10 analogue with potent nootropic effects through BDNF/NGF upregulation — complementing Cortagen's epigenetic neuroprotection with acute neurotrophic signaling.
Dual-layer cognitive enhancement: long-term epigenetic neuroprotection (Cortagen) plus immediate neurotrophic factor amplification (Semax).
Selank provides anxiolytic and immune-modulating effects that support the cognitive environment Cortagen creates — reducing neuroinflammation and stress-related cognitive impairment.
Neuroprotection (Cortagen) plus anxiolysis and neuroinflammation control (Selank) for comprehensive cognitive optimization.
Pinealon is another Khavinson bioregulator targeting the pineal-brain axis — combining with Cortagen covers both cortical neuroprotection and pineal neuroendocrine function.
Two complementary Khavinson bioregulators addressing cortical function (Cortagen) and sleep/melatonin/neuroprotection (Pinealon) for full CNS bioregulation.
Dihexa is one of the most potent synaptogenic compounds known — its ability to form new synaptic connections complements Cortagen's neuroprotective gene activation.
Protect existing neurons (Cortagen) while building new synaptic connections (Dihexa) — comprehensive cognitive architecture support.
Especificaciones
Cómo Funciona Cortagen
Cortagen is a synthetic tetrapeptide bioregulator that acts primarily on the brain and central nervous system. It interacts with DNA regulatory sequences in neural cells to modulate gene expression related to antioxidant enzyme production, neurotransmitter synthesis, and the balance between pro-oxidant and antioxidant processes. Cortagen has been shown to normalize cerebral cortex function, restore the balance of excitatory and inhibitory neurotransmission, and protect neurons from oxidative damage in aging models.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
20mg | $90.00 | $765.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Cortagen is classified as a research peptide only. The Khavinson bioregulator platform has not undergone FDA regulatory review. All information is for research and educational purposes.
Not a treatment for neurological disease
Cortagen is not a treatment for Alzheimer's, Parkinson's, stroke, or any neurological condition. Neurological diseases require professional medical diagnosis and evidence-based treatment. Never discontinue prescribed medications.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
Péptidos Relacionados
AICAR
Compuesto mimético del ejercicio estudiado para la activación metabólica
ARA290 (Cibinetide)
Estudiado para neuroprotección mediante señalización no hematopoyética derivada de EPO
ACE 031
Estudiado para la inhibición de la vía de miostatina en investigación muscular
ACTH 1-39
Estudiado para la modulación de respuesta al estrés mediada por melanocortina