5-AMINO-1MQ

5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that methylates and inactivates nicotinamide (a NAD+ precursor). By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD+ and S-adenosylmethionine (SAM) levels, activating SIRT1 and other NAD+-dependent metabolic enzymes. This leads to increased energy expenditure, enhanced fatty acid oxidation, reduced lipogenesis, and decreased adipocyte size. It effectively reverses diet-induced energy-balance research in preclinical models without affecting food intake.