PE-22-28 - Front - MiPeptidos
Cognitive / Neuropeptides

PE-22-28

CAS: 1801959-12-5

PE-22-28 is a research peptide in the cognitive / neuropeptides category. PE-22-28 is a synthetic heptapeptide fragment of spadin that acts as a potent and selective inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore domain potassium channel involved in mood regulation. MiPeptidos offers PE-22-28 in 2 sizes with 99.4% verified purity and full analytical documentation.

Starting at
$22.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How PE-22-28 Works

PE-22-28 is a synthetic heptapeptide fragment of spadin that acts as a potent and selective inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore domain potassium channel involved in mood regulation. TREK-1 knockout mice exhibit antidepressant-like behavior, and PE-22-28 mimics this by blocking TREK-1 with an IC50 of 0.12 nM. This leads to increased neuronal excitability in mood-regulating brain regions, enhanced serotonergic neurotransmission, and stimulation of hippocampal neurogenesis. It represents a novel non-monoamine mechanism for antidepressant research.

Research Applications

1
Antidepressant mechanisms beyond monoamine hypothesis
2
TREK-1 potassium channel pharmacology
3
Hippocampal neurogenesis
4
Anxiety and mood disorder research
5
Novel antidepressant drug development
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$22.95$167.95
10mgBest Value
$31.95$232.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.4%purity
mAURetention Time (min)0250500750100005101520253099.4%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
PE-22-28
PASSES ALL SPECIFICATIONS
Batch NumberHR-P222-2600315
Date of AnalysisFebruary 12, 2026
Purity (HPLC)99.4%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)773.89 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg PE-22-28 + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed PE-22-28 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Chris Bradley·Columbus, OH

PE-22-28 is a spadin analog we use for TREK-1 channel inhibition in our antidepressant mechanism studies. MiPeptidos delivers this niche neuropeptide at research-grade purity with proper analytical documentation. Our ele...

Nov 25, 2025
View All Reviews →

Frequently Asked Questions

PE-22-28 (CAS: 1801959-12-5) is a research compound, with a molecular weight of 773.89 Da in the Cognitive / Neuropeptides category. PE-22-28 is a synthetic heptapeptide fragment of spadin that acts as a potent and selective inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore domain potassium channel involved in mood regulation. TREK-1 knockout mice exhibit antidepressant-like behavior, and PE-22-28 mimics this by blocking TREK-1 with an IC50 of 0.12 nM. Researchers commonly investigate PE-22-28 for Antidepressant mechanisms beyond monoamine hypothesis, TREK-1 potassium channel pharmacology, Hippocampal neurogenesis. Every vial from MiPeptidos includes batch-specific analytical documentation.
PE-22-28 is available in 2 sizes (5mg, 10mg), so reconstitution volume depends on which vial you have. For the 5mg size, add 1-2mL of bacteriostatic water; for the 10mg size, use 2-3mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted PE-22-28 at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
PE-22-28 and Dihexa are both potent nootropic compounds, but PE-22-28 is a heptapeptide fragment of the neuroprotective protein PEDF (pigment epithelium-derived factor) that enhances neurogenesis in the hippocampus and promotes memory consolidation. Dihexa instead amplifies HGF/c-Met synaptogenic signaling at picomolar potency. PE-22-28 (774 Da) acts through PEDF receptor pathways to promote neural stem cell differentiation. MiPeptidos carries both for comparative cognitive enhancement research.
Store lyophilized PE-22-28 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, PE-22-28 has a reported half-life of Not fully characterized in clinical settings, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every PE-22-28 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-P222-2600315, tested February 12, 2026) shows 99.4% purity by HPLC, mass spectrometry confirmation at 773.89 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
1801959-12-5
Mol. Weight
773.89 Da
Formula
C35H55N11O9
Half-Life
Not fully characterized in clinical settings
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg, 10mg

Sequence

Gly-Val-Ser-Trp-Gly-Leu-Arg (heptapeptide; TREK-1 channel inhibitor)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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