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HPLC Purity Analysis
PE-22-28
CAS: 1801959-12-5
Antidepressant mechanisms beyond monoamine hypothesis · TREK-1 potassium channel pharmacology · Hippocampal neurogenesis
PE-22-28 is a synthetic heptapeptide fragment of spadin that acts as a potent and selective inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore domain potassium channel involved in mood regulation.
- Antidepressant mechanisms beyond monoamine hypothesis
- TREK-1 potassium channel pharmacology
- Hippocampal neurogenesis
- Anxiety and mood disorder research
This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.
Frequently Bought Together
Bacteriostatic Water
Required for reconstitution
Adamax
Cognitive / Neuropeptides
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HPLC Purity Analysis
Specifications
How PE-22-28 Works
PE-22-28 is a synthetic heptapeptide fragment of spadin that acts as a potent and selective inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore domain potassium channel involved in mood regulation. TREK-1 knockout mice exhibit antidepressant-like behavior, and PE-22-28 mimics this by blocking TREK-1 with an IC50 of 0.12 nM. This leads to increased neuronal excitability in mood-regulating brain regions, enhanced serotonergic neurotransmission, and stimulation of hippocampal neurogenesis. It represents a novel non-monoamine mechanism for antidepressant research.
Research Applications
Pricing
| Size | Per Vial | 10-Pack |
|---|---|---|
5mg | $40.00 | $400.00 |
10mgBest Value | $70.00 | $700.00 |
10-pack pricing shown. Volume discounts for 50+ vials — contact us.
Certificate of Analysis
This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.
Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.
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