P21 (P021) - Front - MiPeptidos
Cognitive / Neuropeptides

P21 (P021)

CAS: Not assigned

P21 (P021) is a research peptide in the cognitive / neuropeptides category. P21 is a synthetic peptide derived from a short epitope (residues 148-151) of ciliary neurotrophic factor (CNTF) with an adamantane moiety appended for blood-brain barrier penetration and oral bioavailability. MiPeptidos offers P21 (P021) in 1 sizes with 99.8% verified purity and full analytical documentation.

Starting at
$132.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How P21 (P021) Works

P21 is a synthetic peptide derived from a short epitope (residues 148-151) of ciliary neurotrophic factor (CNTF) with an adamantane moiety appended for blood-brain barrier penetration and oral bioavailability. It enhances BDNF expression by inhibiting leukemia inhibitory factor (LIF) signaling, promotes dentate gyrus neurogenesis, inhibits GSK-3beta activity (reducing tau phosphorylation), and provides neuroprotection without the adverse effects associated with full-length CNTF administration.

Research Applications

1
Alzheimer's disease and tau pathology
2
Hippocampal neurogenesis stimulation
3
BDNF upregulation via novel pathway
4
Oral nootropic peptide design
5
Cognitive enhancement in aging models
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$132.95$970.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.8%purity
mAURetention Time (min)0250500750100005101520253099.8%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
P21 (P021)
PASSES ALL SPECIFICATIONS
Batch NumberHR-P21P-2600115
Date of AnalysisFebruary 4, 2026
Purity (HPLC)99.8%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)578.30 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg P21 (P021) + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed P21 (P021) product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

4.0/5from 1 review
Verified
Dr. Helen Park·Cambridge, MA

P21 is a CNTF-derived peptide we study for neurogenesis. The peptide shows expected hippocampal neurogenic activity in our cell assays. Four stars because I wish MiPeptidos offered larger vial sizes for this peptide spec...

Feb 13, 2026
View All Reviews →

Frequently Asked Questions

P21 (P021) (CAS: Not assigned) is a research compound, with a molecular weight of 578.30 Da in the Cognitive / Neuropeptides category. P21 is a synthetic peptide derived from a short epitope (residues 148-151) of ciliary neurotrophic factor (CNTF) with an adamantane moiety appended for blood-brain barrier penetration and oral bioavailability. It enhances BDNF expression by inhibiting leukemia inhibitory factor (LIF) signaling, promotes dentate gyrus neurogenesis, inhibits GSK-3beta activity (reducing tau phosphorylation), and provides neuroprotection without the adverse effects associated with full-length CNTF administration. Researchers commonly investigate P21 (P021) for Alzheimer's disease and tau pathology, Hippocampal neurogenesis stimulation, BDNF upregulation via novel pathway. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your P21 (P021) 5mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 1-2mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted P21 (P021) at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
P21 (P021) is a small molecule CNTF (ciliary neurotrophic factor) mimetic (578 Da) that promotes neurogenesis and inhibits tau hyperphosphorylation — making it directly relevant to Alzheimer disease models. PE-22-28 drives neurogenesis through PEDF receptor pathways instead. P21 competitively inhibits leukemia inhibitory factor (LIF) signaling to selectively activate CNTF-like neurotrophic effects without LIF-driven inflammation. MiPeptidos offers both for neuroregeneration research.
Store lyophilized P21 (P021) at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, P21 (P021) has a reported half-life of Suitable for once-daily oral dosing (specific half-life data from preclinical models), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every P21 (P021) order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-P21P-2600115, tested February 4, 2026) shows 99.8% purity by HPLC, mass spectrometry confirmation at 578.30 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
Not assigned
Mol. Weight
578.30 Da
Formula
C30H54N6O5
Half-Life
Suitable for once-daily oral dosing (specific half-life data from preclinical models)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg

Sequence

Ac-Asp-Gly-Gly-Leu-(Adamantyl-Gly)-NH2 (modified pentapeptide with adamantane moiety)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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