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Orexin B - Front - MiPeptidos
Cognitive / Neuropeptides

Orexin B

CAS: 205640-91-1

OX2R-selective orexin signaling · REM sleep regulation · Narcolepsy treatment research

Orexin B is a 28-amino acid neuropeptide co-expressed with Orexin A in lateral hypothalamic neurons.

  • OX2R-selective orexin signaling
  • REM sleep regulation
  • Narcolepsy treatment research
  • Autonomic nervous system modulation
Research Use Only.

This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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≥99% HPLC| COA Included| Ships Today
≥99% Purity
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HPLC Purity Analysis

High-Performance Liquid Chromatography
99.1%purity
mAURetention Time (min)0250500750100005101520253099.1%
Method: RP-HPLC C18UV 220nmACN/H₂O + 0.1% TFA
CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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Batch Tracked

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS
205640-91-1
Mol. Weight
2899.40 Da

How Orexin B Works

Orexin B is a 28-amino acid neuropeptide co-expressed with Orexin A in lateral hypothalamic neurons. Unlike Orexin A (which binds both OX1R and OX2R equally), Orexin B preferentially binds OX2R with ~10-fold selectivity over OX1R. It promotes wakefulness primarily through OX2R-mediated arousal pathways, regulates REM sleep, modulates autonomic functions, and influences glucose homeostasis. It has less potent effects on feeding compared to Orexin A.

Research Applications

1
OX2R-selective orexin signaling
2
REM sleep regulation
3
Narcolepsy treatment research
4
Autonomic nervous system modulation
5
OX1R vs OX2R receptor pharmacology

Pricing

SizePer Vial10-Pack
5mg
$100.00$1000.00
10mgBest Value
$180.00$1800.00

10-pack pricing shown. Volume discounts for 50+ vials — contact us.

Certificate of Analysis

MiPeptidos
Orexin B
PASSES ALL SPECIFICATIONS
Batch NumberHR-RXNB-2600315
Date of AnalysisJanuary 17, 2026
Purity (HPLC)99.1%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)2899.40 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.