Orexin A - Front - MiPeptidos
Cognitive / Neuropeptides

Orexin A

CAS: 205640-90-0

Orexin A is a research peptide in the cognitive / neuropeptides category. Orexin A is a neuropeptide produced by hypothalamic orexin neurons that binds with high affinity to both OX1R and OX2R receptors. MiPeptidos offers Orexin A in 1 sizes with 99.2% verified purity and full analytical documentation.

Starting at
$259.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
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How Orexin A Works

Orexin A is a neuropeptide produced by hypothalamic orexin neurons that binds with high affinity to both OX1R and OX2R receptors. It is the primary regulator of wakefulness, arousal, and the sleep-wake cycle. Orexin A promotes alertness by exciting monoaminergic and cholinergic neurons in the brainstem arousal centers, stimulates feeding behavior, increases metabolic rate, and regulates reward-motivated behavior. Loss of orexin neurons causes narcolepsy type 1 with cataplexy.

Research Applications

1
Narcolepsy and sleep-wake disorders
2
Wakefulness and arousal mechanisms
3
Appetite and feeding behavior regulation
4
Reward circuitry and addiction research
5
Cognitive alertness enhancement
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$259.95$1897.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.2%purity
mAURetention Time (min)0250500750100005101520253099.2%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Orexin A
PASSES ALL SPECIFICATIONS
Batch NumberHR-RXN-2600315
Date of AnalysisMarch 18, 2026
Purity (HPLC)99.2%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)3561.19 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg Orexin A + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Orexin A product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Kenji Watanabe·Nagoya, Japan

Orexin-A (hypocretin-1) from MiPeptidos is critical for our narcolepsy and wakefulness research. The 33-amino-acid neuropeptide with two disulfide bonds is correctly folded as confirmed by our circular dichroism analysis...

Jan 20, 2026
View All Reviews →

Frequently Asked Questions

Orexin A (CAS: 205640-90-0) is a research compound, with a molecular weight of 3561.19 Da in the Cognitive / Neuropeptides category. Orexin A is a neuropeptide produced by hypothalamic orexin neurons that binds with high affinity to both OX1R and OX2R receptors. It is the primary regulator of wakefulness, arousal, and the sleep-wake cycle. Researchers commonly investigate Orexin A for Narcolepsy and sleep-wake disorders, Wakefulness and arousal mechanisms, Appetite and feeding behavior regulation. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your Orexin A 10mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 2-3mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted Orexin A at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
Orexin A and Orexin B are both hypothalamic neuropeptides that promote wakefulness, but Orexin A (33 amino acids, 3561 Da) activates both OX1R and OX2R receptors with equal potency, while Orexin B (28 amino acids, 2899 Da) preferentially binds OX2R. Orexin A has two disulfide bonds making it more stable and longer-acting, and it also crosses the blood-brain barrier more efficiently. For narcolepsy and sleep-wake research, Orexin A provides broader receptor coverage. MiPeptidos offers both.
Store lyophilized Orexin A at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Orexin A has a reported half-life of ~28 minutes in CSF, which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Orexin A order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-RXN-2600315, tested March 18, 2026) shows 99.2% purity by HPLC, mass spectrometry confirmation at 3561.19 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
205640-90-0
Mol. Weight
3561.19 Da
Formula
C152H243N47O44S4
Half-Life
~28 minutes in CSF
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg

Sequence

33-amino acid peptide with N-terminal pyroglutamic acid and two intramolecular disulfide bonds (Cys6-Cys12, Cys7-Cys14); pEPPLPDCSCRLYELLHGAGNHAAGILTL-NH2

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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