Matrixyl - Front - MiPeptidos
Skin / Cosmetic

Matrixyl

CAS: 214047-00-4

Matrixyl is a research peptide in the skin / cosmetic category. Matrixyl is a lipopeptide consisting of the pentapeptide KTTKS conjugated to a palmitic acid chain. MiPeptidos offers Matrixyl in 1 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$16.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How Matrixyl Works

Matrixyl is a lipopeptide consisting of the pentapeptide KTTKS conjugated to a palmitic acid chain. The KTTKS sequence mimics a fragment of type I procollagen propeptide, acting as a matrikine that signals fibroblasts to synthesize new collagen (types I, III, and IV), fibronectin, elastin, and glycosaminoglycans. The palmitoyl chain enhances skin penetration through the lipid-rich stratum corneum. By stimulating extracellular matrix production, Matrixyl reverses visible signs of photoaging and wrinkle formation.

Research Applications

1
Collagen synthesis stimulation
2
Anti-aging and wrinkle reduction
3
Extracellular matrix remodeling
4
Matrikine signaling biology
5
Cosmeceutical efficacy studies
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
10mg
$16.95$123.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Matrixyl
PASSES ALL SPECIFICATIONS
Batch NumberHR-MTRX-2600315
Date of AnalysisMarch 17, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)802.05 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
10.0 mL
10 mg Matrixyl + 10.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Matrixyl product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Emily Watson·Toronto, ON

Matrixyl (palmitoyl pentapeptide-4) from MiPeptidos is our collagen synthesis stimulator in dermatological research. The lipopeptide shows robust procollagen I and III upregulation in our fibroblast cultures. The palmito...

Jan 30, 2026
View All Reviews →

Frequently Asked Questions

Matrixyl (CAS: 214047-00-4) is a research compound, with a molecular weight of 802.05 Da in the Skin / Cosmetic category. Matrixyl is a lipopeptide consisting of the pentapeptide KTTKS conjugated to a palmitic acid chain. The KTTKS sequence mimics a fragment of type I procollagen propeptide, acting as a matrikine that signals fibroblasts to synthesize new collagen (types I, III, and IV), fibronectin, elastin, and glycosaminoglycans. Researchers commonly investigate Matrixyl for Collagen synthesis stimulation, Anti-aging and wrinkle reduction, Extracellular matrix remodeling. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your Matrixyl 10mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 2-3mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted Matrixyl at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
Matrixyl (palmitoyl pentapeptide-4, Pal-KTTKS, 802 Da) and GHK-Cu (copper tripeptide, 404 Da) both stimulate collagen synthesis, but through different pathways. Matrixyl activates TGF-beta signaling and TIMP-1 (tissue inhibitor of metalloproteinases) to boost collagen I, III, and IV production. GHK-Cu uses copper-dependent enzyme activation for wound remodeling. Matrixyl palmitoyl chain enhances skin penetration for topical research. MiPeptidos offers both for extracellular matrix biology studies.
Store lyophilized Matrixyl at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Matrixyl has a reported half-life of Topical application; systemic half-life not applicable. Local matrix effects are cumulative over weeks., which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Matrixyl order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-MTRX-2600315, tested March 17, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at 802.05 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
214047-00-4
Mol. Weight
802.05 Da
Formula
C39H75N7O10
Half-Life
Topical application; systemic half-life not applicable. Local matrix effects are cumulative over weeks.
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
10mg

Sequence

Pal-Lys-Thr-Thr-Lys-Ser (pentapeptide with N-terminal palmitoyl group for skin penetration)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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