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Análisis de Pureza HPLC
Melanotan II
CAS: 121062-08-6
Agonista de melanocortina multi-receptor estudiado para diversas vías
Melanotan II is a research peptide in the sexual health / hormonal category. Melanotan II is a non-selective cyclic melanocortin receptor agonist that activates MC1R, MC3R, MC4R, and MC5R. MiPeptidos offers Melanotan II in 1 sizes with 99.7% verified purity and full analytical documentation.
- Visible tan within days
- Reduced snack cravings
- Heightened libido
- Leaner body composition
Studies report visible skin darkening within 5-7 days and appetite suppression starting in the first week. By weeks 3-6, tanning deepens significantly, appetite reduction becomes pronounced, and sexual arousal effects heighten. During maintenance at weeks 7-10, effects hold with just twice-weekly use.
$34.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Tan. Lean. Desire.
10-week multi-receptor protocol studied across melanogenesis, appetite, and sexual function
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-MSH developed at the University of Arizona. Unlike Melanotan I, MT-II is a non-selective melanocortin agonist that activates MC1R (tanning), MC3R (energy homeostasis, sexual function), MC4R (appetite suppression, sexual arousal), and MC5R (exocrine gland function).
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Robert Dorr
Professor of Pharmacology, University of Arizona College of Medicine
Co-developer of Melanotan II. Led Phase I clinical trials at the University of Arizona. Pioneer in melanocortin pharmacology and peptide drug development.
Melanotan II is the most potent tanning agent we have ever produced. A single 0.025 mg/kg dose produces measurable increases in melanin density within days. The challenge is its non-selectivity — you get tanning, appetite suppression, and sexual effects all at once.
Research dosing: 0.025 mg/kg subcutaneous. Clinical trials used single doses and brief courses. The melanogenic effect persists for weeks after cessation.
Fuente: Dorr et al. (1996) Life Sciences; University of Arizona Phase I trial publications
Dr. Victor Hruby
Regents Professor of Chemistry, University of Arizona
Co-inventor of Melanotan II. National Academy of Sciences member. Over 1,000 publications in peptide chemistry. Chiron Award recipient for lifetime achievement in medicinal chemistry.
The cyclic structure of Melanotan II gives it enhanced potency and stability compared to linear alpha-MSH. Its non-selectivity was actually the starting point that allowed us to develop selective agents like PT-141 and SHU-9119.
The cyclic lactam bridge is critical for activity. Dose-response is steep — start at the lowest effective dose and titrate carefully. The melanogenic and sexual effects have different dose-response curves.
Fuente: Hruby et al. (1995) Journal of Medicinal Chemistry; Annals NY Academy of Sciences
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally.
Melanotan II hits multiple melanocortin receptors — MC1R for tanning, MC3R and MC4R for libido and appetite. It's a shotgun approach versus PT-141 which is a rifle shot at just the sexual function receptors. The trade-off is more side effects.
If your goal is tanning only, Melanotan I is more selective. If you want the combined effects, start very low — 0.25 mg — and titrate up. Nausea is nearly universal at higher doses. Watch your moles carefully.
Fuente: Huberman Lab Podcast: Skin Health & Appearance (2024)
Dr. Predrag Sikiric
Professor of Pharmacology, University of Zagreb
World authority on peptide therapeutics. 30+ years in peptide research including melanocortin interactions with gut peptides.
The melanocortin system interacts bidirectionally with the gut-brain axis. MC4R activation simultaneously modulates feeding behavior, energy expenditure, and autonomic nervous system tone — explaining the multi-system effects of non-selective agonists.
Consider the melanocortin system as a master regulatory network. Non-selective agonism produces coordinated but complex physiological responses that require careful monitoring.
Fuente: Current Neuropharmacology (2016); peptide interaction review publications
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Begin at 0.25 mg to assess tolerance. Nausea is very common at initiation. Pre-dose with ginger or antiemetic if needed. Evening dosing reduces visible flushing. Visible tanning begins within 5-7 days.
Peak melanin production phase. Appetite suppression becomes pronounced. Sexual arousal effects heighten. Brief UV exposure (10-15 min) can synergize but is not required for melanogenesis.
Reduced frequency maintains achieved pigmentation. Melanin has a natural turnover of ~28-40 days. Research participants maintain with just 1-2 doses per week once desired color is achieved.
Add 1 mL bacteriostatic water to 10 mg vial = 10 mg/mL. 0.25 mg = 2.5 units; 0.5 mg = 5 units; 1.0 mg = 10 units on insulin syringe.
Typical: 6-8 weeks loading, then maintenance 1-2x/week. Some protocols cycle 8 weeks on, 4-6 weeks off. Tanning persists 4-6 weeks after cessation. No established cycling guidelines — community-derived protocols.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 30 days. Protect from light. Short half-life (~33 min) means timing matters less than with longer-acting peptides.
Subcutaneous injection only. Evening dosing preferred (reduces visible flushing, nausea can be slept through). Inject slowly. Rotate sites. Some subjects split doses (0.25 mg AM + 0.25 mg PM) to reduce peak side effects.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Receptor Activation & Initial Side Effects
- MC1R activation begins melanocyte stimulation within hours of first dose
- Nausea is nearly universal in the first 3-5 doses; typically diminishes by day 7
- Facial flushing occurs 15-60 minutes post-injection in published data shows
- Appetite suppression noticeable from first dose via MC4R activation
- Sexual arousal effects (spontaneous erections in males) may occur from first dose
Base de investigación: Dorr et al. (1996) Life Sciences; Phase I UA trial data
Visible Melanogenesis & Side Effect Adaptation
- Clear visible tanning in most skin types, even without UV exposure
- Existing freckles, moles, and nevi may darken noticeably
- Nausea and flushing typically resolve or become manageable
- Appetite remains suppressed — some studies report 20-30% reduced caloric intake
- Sexual effects stabilize at consistent enhancement level
Base de investigación: Dorr et al. (1996) Life Sciences; Hadley & Dorr (2006) Peptides
Peak Melanin Density & Multi-System Effects
- Maximum tanning effect typically reached by weeks 6-8
- Melanin density measurably elevated on spectrophotometry
- Photoprotective benefit: MED increased 1.5-2.5x vs baseline
- Sustained appetite reduction and lean body composition changes reported anecdotally
- Transition to maintenance dosing as desired pigmentation level is reached
Base de investigación: Barnetson et al. (2006) PMID: 17141180; community experience data
Maintenance & Gradual Normalization
- Reduced dosing frequency (1-2x/week) sustains pigmentation
- Appetite and sexual effects diminish between doses at maintenance frequency
- Pigmentation gradually fades over 4-8 weeks upon complete cessation
- Mole darkening typically reverses but may persist in some cases
Base de investigación: Community-derived maintenance protocols; melanin turnover biology
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
Non-Selective Melanocortin Receptor Agonism
MT-II activates MC1R, MC3R, MC4R, and MC5R simultaneously due to its cyclic structure and high receptor affinity, producing tanning, sexual, appetite, and exocrine effects.
- MC1R: melanocyte activation → eumelanin production (tanning)
- MC3R: energy homeostasis modulation + sexual arousal contribution
- MC4R: hypothalamic appetite suppression + central sexual arousal (primary)
- MC5R: exocrine gland regulation (sebaceous, lacrimal)
Hadley & Dorr (2006) PMID: 16563566
MC4R Hypothalamic Appetite Suppression
MC4R activation in the arcuate and paraventricular nuclei of the hypothalamus suppresses NPY/AgRP orexigenic signaling and activates POMC/CART anorexigenic pathways.
- MC4R is the primary receptor for melanocortin-mediated appetite regulation
- Loss-of-function MC4R mutations cause the most common form of monogenic obesity
- MT-II-mediated appetite suppression is dose-dependent and rapidly reversible
Butler & Cone (2003) PMID: 12858176
Central Sexual Arousal via MC3R/MC4R
MC3R and MC4R activation in the medial preoptic area and PVN of the hypothalamus triggers downstream dopaminergic and oxytocinergic signaling for sexual arousal.
- MC4R activation in PVN → oxytocin release → pro-erectile signaling
- MC3R modulation of dopamine in mPOA enhances sexual motivation
- Mechanism is central (brain-mediated), not peripheral (vascular) — effective even in PDE5 non-responders
Wessells et al. (1998) PMID: 9630491; Wessells et al. (2000) PMID: 11045912
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
α-Melanocyte-stimulating hormone analogue (Melanotan-II) in healthy male volunteers: Phase I clinical trial
Dorr RT, Lines R, Levine N, et al. — Life Sciences (1996)
Hallazgo Clave: Phase I trial: MT-II (0.025 mg/kg SC) produced significant increases in melanin density within days. Nausea, facial flushing, and spontaneous penile erections were dose-dependent side effects.
The Effects of Melanotan II on Erectile Function
Wessells H, Fuciarelli K, Hansen J, et al. — Journal of Urology (1998)
Hallazgo Clave: MT-II (0.025 mg/kg SC) produced clinically meaningful erections in 8 of 10 men, including men with organic erectile dysfunction. RigiScan-confirmed erections lasting 45+ minutes.
Melanotan II: A Non-Selective MC Receptor Agonist for Sexual Dysfunction and Tanning
Hadley ME, Dorr RT — Peptides (2006)
Hallazgo Clave: Comprehensive review of MT-II pharmacology. Confirmed cyclic lactam bridge provides metabolic stability and enhanced receptor binding. Sexual effects are MC3R/MC4R mediated; tanning is MC1R mediated.
Design of potent cyclic α-MSH analogues
Hruby VJ, Lu D, Sharma SD, et al. — Journal of Medicinal Chemistry (1995)
Hallazgo Clave: Defined the structure-activity relationship of MT-II. The D-Phe7 substitution and Asp-Lys lactam bridge are critical for potency. MT-II is 100-1000x more potent than α-MSH at melanocortin receptors.
Melanotan II and penile erection in men with psychogenic erectile dysfunction
Wessells H, Levine N, Hadley ME, et al. — International Journal of Impotence Research (2000)
Hallazgo Clave: Double-blind RCT: MT-II initiated erections in patients with psychogenic ED — demonstrating central arousal mechanism independent of peripheral vascular function.
Melanocortins and body weight regulation: glucocorticoids, agouti-related protein, and beyond
Butler AA, Cone RD — Nature Neuroscience (2003)
Hallazgo Clave: MC4R is the primary receptor mediating appetite suppression in the melanocortin system. Loss-of-function MC4R mutations are the most common monogenic cause of obesity — confirming the pathway MT-II activates.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Melanotan II con estos péptidos para mecanismos complementarios.
PT-141 is the selective sexual function derivative of MT-II. They share MC3R/MC4R activity but are typically used as alternatives, not combined.
Use MT-II when tanning + sexual function are both desired. Use PT-141 when only sexual function is the goal. Do not combine — overlapping receptor targets.
GHK-Cu enhances skin quality, collagen, and repair while MT-II drives melanogenesis for combined skin appearance benefits.
Combines even, natural-looking pigmentation with improved skin texture, firmness, and overall complexion quality.
MT-II provides appetite suppression via MC4R while AOD-9604 directly stimulates fat metabolism for enhanced body composition.
Dual approach to body composition: reduced caloric intake from MT-II plus enhanced fat breakdown from AOD-9604, with tanning as an additional benefit.
BPC-157 can mitigate the significant GI side effects (nausea) that are common with MT-II, especially during the loading phase.
BPC-157 may allow subjects to tolerate MT-II's loading phase with less nausea, improving compliance with the melanogenesis protocol.
Especificaciones
Cómo Funciona Melanotan II
Melanotan II is a non-selective cyclic melanocortin receptor agonist that activates MC1R, MC3R, MC4R, and MC5R. MC1R activation stimulates melanogenesis (tanning), MC3R/MC4R activation in the CNS produces sexual arousal and appetite suppression effects, and MC5R modulation may influence exocrine gland function. Unlike the linear Melanotan I, the cyclic structure provides broader receptor activation, producing simultaneous tanning, sexual arousal, appetite suppression, and fat mobilization.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
10mgOferta | $34.95$50.00 | $297.07 | 30% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not approved for human use in any jurisdiction
MT-II has never received regulatory approval anywhere in the world. It is classified as a research peptide only. Multiple health authorities (TGA, MHRA, FDA) have issued warnings against its use.
Mandatory dermatological monitoring
Non-selective melanocyte activation may promote changes in existing nevi. Multiple case reports of melanoma diagnosis temporally associated with MT-II use. Regular full-body skin checks with dermoscopy required.
Contraindicated with melanoma history or family risk
MC1R stimulation drives melanocyte proliferation. Any personal or family history of melanoma is an absolute contraindication. Also avoid if you have dysplastic nevus syndrome or numerous atypical moles.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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