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Análisis de Pureza HPLC
Kisspeptin-10
CAS: 374675-21-5
Estudiado para la modulación del eje HPG y pulsatilidad de GnRH
Kisspeptin-10 is a research peptide in the sexual health / hormonal category. Kisspeptin-10 is the minimal active fragment of the full-length kisspeptin encoded by the KISS1 gene. MiPeptidos offers Kisspeptin-10 in 2 sizes with 99.1% verified purity and full analytical documentation.
- Supports healthy LH and FSH
- Restores hormonal drive
- Works with your body's rhythm
- Improved reproductive health
Research suggests kisspeptin-10 can trigger a measurable hormone response within hours of use. Over the first 2-4 weeks, studies report gradual improvements in energy and hormonal well-being. By weeks 6-8, the full protocol supports sustained reproductive axis activity through the body's own GnRH signaling.
$28.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Restore Hormonal Drive.
8-week HPG axis protocol backed by 5 clinical studies from leading reproductive endocrinology centers
Kisspeptin-10 is the biologically active C-terminal decapeptide fragment of kisspeptin (also known as metastin), the endogenous ligand for the KISS1R (GPR54) receptor. It is the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis — kisspeptin neurons in the arcuate and AVPV/PeN nuclei of the hypothalamus directly stimulate GnRH neurons, making kisspeptin the gatekeeper of reproductive hormone release.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Waljit Dhillo
Professor of Endocrinology, Imperial College London
World's leading clinical kisspeptin researcher. Led the pioneering studies demonstrating kisspeptin's ability to trigger LH release and oocyte maturation in humans. Over 100 publications on kisspeptin signaling.
Kisspeptin is the master switch for reproduction. A single injection can trigger a cascade of hormone release that activates the entire reproductive axis. In IVF, kisspeptin can mature eggs with virtually zero risk of ovarian hyperstimulation syndrome.
IV bolus: 1.0-6.4 nmol/kg for acute LH release. Subcutaneous: 6.4 nmol/kg for sustained response. For IVF egg maturation: single SC dose of kisspeptin-54 at 9.6 nmol/kg.
Fuente: Jayasena et al. (2011) JCEM PMID: 21752887; multiple Imperial College publications
Dr. Stephanie Seminara
Professor of Medicine, Harvard Medical School / MGH
Chief of the Reproductive Endocrine Unit at Massachusetts General Hospital. Co-discoverer of the KISS1R/GPR54 role in puberty and reproduction. Landmark 2003 NEJM paper.
The discovery that loss-of-function mutations in GPR54 cause hypogonadotropic hypogonadism established kisspeptin as indispensable for human reproduction. It sits at the very top of the reproductive hormone cascade.
Kisspeptin is the most physiological way to stimulate the reproductive axis — it works through the body's own GnRH system rather than bypassing it. Research dosing: IV bolus of kisspeptin-10 at 0.24 nmol/kg for diagnostic HPG axis assessment.
Fuente: de Roux et al. (2003) PNAS; Seminara et al. (2003) NEJM PMID: 14614226
Dr. Robert Millar
Director, UCT/MRC Receptor Biology Research Unit
Professor at University of Cape Town and University of Edinburgh. Pioneer in GnRH and kisspeptin receptor pharmacology. Over 500 publications in reproductive neuroendocrinology.
Kisspeptin neurons integrate metabolic, stress, and circadian signals to gate GnRH release. This makes kisspeptin not just a reproductive regulator but a sensor that couples the body's overall state to reproductive capacity.
Kisspeptin-10 is the minimal active fragment. Shorter half-life than kisspeptin-54 means more pulse-like GnRH stimulation. Research should explore both acute bolus and pulsatile infusion paradigms.
Fuente: Millar et al. (2010) Journal of Neuroendocrinology; Endocrine Reviews
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally.
Kisspeptin is upstream of everything in the reproductive axis — it tells GnRH neurons when to fire, which then tells the pituitary to release LH and FSH. If you want to stimulate the entire cascade physiologically, kisspeptin is the most natural entry point.
Kisspeptin is being explored for its potential to restore HPG axis function rather than replace hormones. Short half-life means it works in pulses — which is how the reproductive axis naturally operates.
Fuente: Huberman Lab Podcast: Hormones & Reproduction (2023)
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Used to assess HPG axis responsiveness. Measure LH, FSH, and testosterone/estradiol at baseline and 30, 60, 120 minutes post-injection. A robust LH rise confirms intact GnRH neuron function.
Daily kisspeptin pulses stimulate GnRH pulsatility and downstream LH/FSH release. Split dosing (AM/PM) may better mimic physiological pulsatility. Monitor gonadotropins and sex steroids weekly.
Reduced dose for sustained HPG axis support. Unlike GnRH agonists, kisspeptin does not cause receptor downregulation at physiological pulse frequencies. Reassess hormone levels at week 4 and 8.
Add 1 mL bacteriostatic water to 5 mg vial = 5 mg/mL (5,000 mcg/mL). 200 mcg = 4 units; 400 mcg = 8 units on insulin syringe.
Short half-life (~28 min) means each dose acts as a discrete GnRH pulse. No receptor downregulation observed with daily dosing in clinical studies up to 8 weeks. Cycling may not be necessary but 4-8 weeks on, 4 weeks off is a conservative approach.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 14-21 days (shorter stability than larger peptides). Protect from light and repeated freeze-thaw cycles.
Subcutaneous injection preferred for research use. IV bolus used in clinical studies for rapid LH assessment. SC provides a more sustained GnRH pulse. Timing: morning dosing aligns with natural cortisol-gonadotropin rhythms.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Acute GnRH Pulse & LH Surge
- KISS1R activation on GnRH neurons within minutes of administration
- LH rises measurably within 30 minutes, peaks at 60-90 minutes
- FSH rise is more modest and delayed compared to LH
- Testosterone/estradiol elevation detectable within 4-6 hours post-LH surge
- Response magnitude is dose-dependent: higher doses produce larger LH pulses
Base de investigación: Jayasena et al. (2011) JCEM PMID: 21752887; Dhillo et al. (2005) JCEM PMID: 16204368
Repeated Pulsatile Stimulation & Axis Priming
- Daily kisspeptin dosing produces repeated GnRH pulses
- LH pulse amplitude and frequency stabilize at enhanced levels
- Pituitary gonadotropes become sensitized to repeated GnRH stimulation
- Baseline testosterone/estradiol levels begin to rise with sustained gonadotropin support
- No desensitization observed — kisspeptin does not downregulate KISS1R with daily dosing
Base de investigación: Jayasena et al. (2013) JCEM; George et al. (2011) JCEM PMID: 21346074
HPG Axis Restoration & Hormonal Optimization
- Sustained improvement in gonadotropin profiles (LH, FSH)
- Measurable increases in testosterone (males) or estradiol (females) from baseline
- In hypothalamic amenorrhea models, kisspeptin restores pulsatile LH secretion
- Improved energy, mood, and well-being reported with normalized sex steroids
- Spermatogenesis/folliculogenesis support via sustained FSH elevation
Base de investigación: Jayasena et al. (2014) JCEM; Abbara et al. (2015) JCEM PMID: 25822104
Assessment & Protocol Decision
- Repeat hormone panel to assess HPG axis status
- If axis is self-sustaining, consider taper or cessation
- If hypogonadism persists, continue or escalate to longer-acting approaches
- Kisspeptin cessation does not cause rebound suppression — axis returns to baseline, not below
Base de investigación: General reproductive endocrinology principles; kisspeptin clinical trial follow-up data
Mecanismo de Acción
4 vías biológicas distintas a través de las cuales opera este péptido.
KISS1R/GPR54 Activation on GnRH Neurons
Kisspeptin-10 binds KISS1R (GPR54) on GnRH neuron cell bodies in the arcuate nucleus, triggering Gq-coupled PLC-IP3-Ca2+ signaling that depolarizes the neuron and initiates GnRH pulse release.
- KISS1R is a Gq-coupled GPCR that activates PLC → IP3 → intracellular Ca2+ release
- Arcuate nucleus KNDy neurons (Kisspeptin/Neurokinin B/Dynorphin) are the GnRH pulse generator
- Kisspeptin is the final common pathway integrating metabolic, stress, and circadian inputs to reproduction
Seminara et al. (2003) PMID: 14614226; Millar et al. (2010) J Neuroendocrinology
Pulsatile GnRH → LH/FSH Release
Kisspeptin-triggered GnRH pulses stimulate pituitary gonadotropes to release LH and FSH in a pulsatile pattern that maintains gonadal function without receptor desensitization.
- Pulsatile GnRH is essential — continuous GnRH causes receptor downregulation and suppression
- Kisspeptin's short half-life (~28 min) naturally produces discrete GnRH pulses
- LH pulse frequency determines the LH:FSH ratio — faster pulses favor LH, slower favor FSH
Dhillo et al. (2005) PMID: 16204368; Jayasena et al. (2014) PMID: 25365220
Metabolic-Reproductive Coupling
Kisspeptin neurons express leptin, insulin, and ghrelin receptors, serving as metabolic sensors that gate reproductive function based on energy availability.
- Low leptin (starvation) → reduced kisspeptin → suppressed GnRH → amenorrhea/hypogonadism
- This explains why severe caloric restriction, eating disorders, and extreme exercise suppress fertility
- Exogenous kisspeptin can override this metabolic brake, restoring reproductive function
Roa et al. (2008) Molecular and Cellular Endocrinology; Jayasena et al. (2011) PMID: 21752887
Sexual Arousal & Reward Integration
Kisspeptin neurons project to limbic regions (amygdala, hippocampus) involved in sexual arousal, attraction, and pair bonding, linking reproductive hormones with sexual behavior.
- fMRI studies show kisspeptin enhances brain activity in response to sexual and romantic stimuli
- Kisspeptin administration increases activation in the posterior cingulate, globus pallidus, and thalamus during sexual image viewing
- Links the hormonal axis directly to psychological aspects of sexual desire and mate selection
Comninos et al. (2017) Journal of Clinical Investigation PMID: 28248200
Investigación Publicada
5 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin release in women with hypothalamic amenorrhea
Jayasena CN, Nijher GM, Chaudhri OB, et al. — Journal of Clinical Endocrinology & Metabolism (2011)
Hallazgo Clave: Kisspeptin-54 (6.4 nmol/kg SC) acutely stimulated LH release in women with hypothalamic amenorrhea, demonstrating that the GnRH neurons remain responsive to kisspeptin even when the HPG axis is suppressed.
GPR54 mutations in hypogonadotropic hypogonadism: the role of kisspeptin in reproductive biology
Seminara SB, Messager S, Chatzidaki EE, et al. — New England Journal of Medicine (2003)
Hallazgo Clave: Landmark discovery: loss-of-function mutations in GPR54 (KISS1R) cause hypogonadotropic hypogonadism with absent puberty, establishing kisspeptin as indispensable for human reproductive function.
Kisspeptin-10 stimulates LH and testosterone release in healthy men
Dhillo WS, Chaudhri OB, Patterson M, et al. — Journal of Clinical Endocrinology & Metabolism (2005)
Hallazgo Clave: First demonstration that kisspeptin-10 IV bolus stimulates LH and testosterone release in healthy men in a dose-dependent manner. LH increased 2-fold within 30 minutes at the highest dose.
Kisspeptin as a trigger for oocyte maturation in IVF: a proof-of-concept study
Abbara A, Jayasena CN, Christopoulos G, et al. — Journal of Clinical Endocrinology & Metabolism (2015)
Hallazgo Clave: Kisspeptin-54 triggered oocyte maturation in IVF patients with ZERO cases of ovarian hyperstimulation syndrome (OHSS) — compared to 7% OHSS rate with standard hCG trigger. Live birth rate comparable.
Twice-daily administration of kisspeptin-54 for 14 days stimulates release of reproductive hormones in women with hypothalamic amenorrhea
Jayasena CN, Abbara A, Veldhuis JD, et al. — Journal of Clinical Investigation (2014)
Hallazgo Clave: 14 days of twice-daily kisspeptin-54 restored pulsatile LH secretion and increased LH pulse frequency in women with hypothalamic amenorrhea. No desensitization observed — efficacy maintained throughout.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Kisspeptin-10 con estos péptidos para mecanismos complementarios.
Kisspeptin stimulates GnRH neurons; gonadorelin acts directly on the pituitary. Together they activate the HPG axis at two sequential levels.
Dual-level HPG axis stimulation ensures both hypothalamic and pituitary responsiveness, useful when assessing or restoring axis function at multiple nodes.
Kisspeptin drives endogenous LH pulses while HCG provides sustained LH-like stimulation of the gonads for comprehensive fertility support.
Combines physiological pulsatile stimulation with sustained gonadal activation — the dual approach used in advanced fertility protocols.
Kisspeptin optimizes the hormonal foundation while PT-141 provides acute central arousal enhancement for comprehensive sexual function support.
Addresses both the hormonal substrate (kisspeptin → testosterone/estradiol) and the neural arousal component (PT-141 → central desire/arousal) of sexual function.
Triptorelin is a GnRH agonist used in PCT to produce an acute LH surge. Kisspeptin provides the upstream physiological stimulation that complements GnRH-level intervention.
Sequential use: triptorelin for acute initial LH surge, then kisspeptin for sustained physiological HPG axis recovery. A rational PCT escalation strategy.
Especificaciones
Cómo Funciona Kisspeptin-10
Kisspeptin-10 is the minimal active fragment of the full-length kisspeptin encoded by the KISS1 gene. It binds to the KISS1R (GPR54) receptor on hypothalamic GnRH neurons, triggering a potent release of gonadotropin-releasing hormone (GnRH). This in turn stimulates pituitary gonadotrophs to release LH and FSH, making kisspeptin the most potent known stimulator of the reproductive endocrine axis. The kisspeptin/GPR54 system serves as the gatekeeper of puberty and fertility.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
5mg | $50.00 | $425.00 | — |
10mgMejor ValorOferta | $49.95$70.00 | $424.57 | 29% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not approved for human use
Kisspeptin-10 is a research peptide only. While clinical trials at Imperial College London and MGH have demonstrated safety, no kisspeptin formulation is FDA-approved. All information is for research purposes only.
Contraindicated in hormone-sensitive cancers
Kisspeptin stimulates sex steroid production via the HPG axis. Contraindicated in breast cancer, prostate cancer, ovarian cancer, or any hormone-receptor-positive malignancy.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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