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Análisis de Pureza HPLC
Adamax
CAS: 2920938-90-3
Análogo mejorado de Semax estudiado para la regulación positiva de BDNF
Adamax is a research peptide in the cognitive / neuropeptides category. Adamax is the most potent modification of Semax, featuring both N-acetylation and C-terminal amidation for enhanced stability, bioavailability, and blood-brain barrier penetration. MiPeptidos offers Adamax in 2 sizes with 99.3% verified purity and full analytical documentation.
- Laser-sharp focus
- Faster information recall
- Enhanced creative thinking
- Better stress resilience
Studies report subtle improvements in focus and mental clarity within the first 3-5 days as BDNF levels begin rising. By weeks 3-4, research suggests noticeable gains in working memory, verbal fluency, and creative problem-solving. Peak cognitive enhancement typically occurs around weeks 5-6, with sustained improvements in learning speed and stress resilience.
$31.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Sharper. Faster. Clearer.
8-week cognitive enhancement protocol backed by neurotrophin research and 4 expert practitioners
Adamax is the most potent modification of the Semax peptide family, featuring both N-acetylation and C-terminal amidation for dramatically enhanced stability, bioavailability, and blood-brain barrier penetration. As an analog of ACTH(4-10), Adamax retains the neurotrophin-stimulating core of its parent compound while resisting enzymatic degradation far more effectively.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Neil Paulvin
Functional & Regenerative Medicine Physician, Manhattan
Known as 'Dr. Peptide.' Specializes in anti-aging, regenerative medicine, and cognitive optimization. Works with Fortune 500 CEOs and professional athletes.
The acetylated and amidated Semax variants like Adamax represent the next generation of nootropic peptides — dramatically better stability means more consistent cognitive enhancement with less frequent dosing.
200-600 mcg/day subcutaneously. Start at the lower end and titrate up based on cognitive response. Cycle 4-8 weeks on, 2-4 weeks off.
Fuente: MindHack Podcast Ep. 92; Clinical practice reports
Dr. William Seeds
Founder, SSRP Institute
40+ years in cellular and molecular medicine. Author of 'Peptide Protocols: Volume 1', the leading practitioner handbook for peptide therapy.
ACTH-derived nootropic peptides work through neurotrophin upregulation rather than stimulant mechanisms — this means sustainable cognitive enhancement without tolerance or crash.
300-600 mcg daily, subcutaneous injection. Can combine with other neuropeptides. Monitor for overstimulation at higher doses.
Fuente: Peptide Protocols: Volume 1 (ISBN: 978-0578624358)
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab, one of the most popular science podcasts globally. Expert in neuroplasticity and BDNF signaling.
BDNF is essentially fertilizer for neurons — it supports the growth, survival, and differentiation of neurons and synapses. Anything that reliably upregulates BDNF has profound implications for learning and memory.
Focus on BDNF upregulation as the primary mechanism. Combine with exercise (which also boosts BDNF) for synergistic effects. Start with minimum effective dose.
Fuente: Huberman Lab Podcast: BDNF & Neuroplasticity episodes (2023-2024)
Dr. Nikolai Myasoedov
Chief Researcher, Institute of Molecular Genetics, Russian Academy of Sciences
Lead developer of the Semax peptide family. Decades of research on ACTH-derived neuropeptides and their clinical applications in Russia.
The acetylated and amidated analogs of Semax demonstrate significantly enhanced nootropic potency and duration of action compared to the parent compound, with preserved safety profiles.
Research protocols use 200-600 mcg subcutaneously in divided doses. Extended stability allows once-daily dosing in most applications.
Fuente: Institute of Molecular Genetics publications; Russian Academy of Sciences
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Start conservatively to assess individual sensitivity. Inject subcutaneously in the morning for optimal cognitive benefit throughout the day. Rotate injection sites. Avoid evening dosing to prevent sleep disruption.
Titrate up based on cognitive response and tolerability. Split dosing (AM + early PM) may provide more sustained effects. Rotate injection sites between abdominal quadrants. Peak BDNF upregulation occurs in this window.
Taper to maintenance level as neurotrophin pathways reach steady state. Transition to cycling pattern. Assess sustained cognitive gains off-peak dosing.
Add 1 mL bacteriostatic water to 5 mg vial = 5,000 mcg/mL. Use an insulin syringe for precise subcutaneous dosing. 200 mcg = 4 units (0.04 mL); 400 mcg = 8 units (0.08 mL).
Standard: 4-8 weeks on, 2-4 weeks off. The enhanced stability of Adamax over Semax allows slightly longer cycles. Cycling maintains neurotrophin receptor sensitivity and prevents downregulation.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 30 days. Protect from light and heat.
Subcutaneous injection into the abdominal fat pad is the recommended route. Use a 29-31 gauge insulin syringe. Pinch a fold of skin, insert at a 45-degree angle, and inject slowly. Rotate injection sites between abdominal quadrants to prevent lipodystrophy.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Neurotrophin Pathway Activation
- BDNF and NGF gene expression changes begin within hours of first dose
- Subtle improvements in focus and mental clarity reported within 3-5 days
- Enhanced attention span during cognitively demanding tasks
- Improved wakefulness and alertness without stimulant-like jitteriness
- Initial mood elevation as serotonergic modulation begins
Base de investigación: Dolotov et al. (2006) Neuroscience; Gyárfás et al. (2010) Journal of Psychopharmacology (Semax family research)
Synaptic Plasticity Enhancement
- Measurable BDNF upregulation reaching peak levels
- Noticeable improvement in working memory and recall speed
- Enhanced verbal fluency and creative problem-solving
- Improved learning rate for new information and skills
- Better stress resilience during cognitive load
Base de investigación: Agapova et al. (2007) Doklady Biological Sciences; Dolotov et al. (2006) Neuroscience
Peak Cognitive Enhancement
- Maximum neurotrophin upregulation and synaptic remodeling
- Sustained improvements in memory consolidation and retrieval
- Enhanced executive function and decision-making speed
- Improved neuroprotective status against oxidative stress
- Studies report peak subjective cognitive enhancement
Base de investigación: Levitskaya et al. (2004) Neuroscience & Behavioral Physiology; general ACTH(4-10) analog research
Consolidation & Cycling
- Cognitive gains stabilize at new baseline
- Taper dosing to assess sustained neuroplastic changes
- Many benefits persist 2-4 weeks after discontinuation due to structural synaptic changes
- Plan cycling strategy: 2-4 week washout before next cycle
Base de investigación: General neurotrophin biology; BDNF-mediated plasticity literature
Mecanismo de Acción
4 vías biológicas distintas a través de las cuales opera este péptido.
BDNF & NGF Upregulation
Potently stimulates transcription and release of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in hippocampal and cortical neurons.
- BDNF mRNA significantly elevated in hippocampus within 3 hours of administration
- NGF co-upregulation supports both cholinergic and glutamatergic neuronal health
- TrkB receptor expression increased alongside BDNF — amplifying downstream signaling
- Acetylation and amidation extend duration of neurotrophin elevation vs unmodified Semax
Dolotov et al. (2006) PMID: 16413131
Melanocortin Receptor Activation (MC3/MC4)
As an ACTH(4-10) analog, Adamax activates melanocortin receptors MC3R and MC4R in the CNS, which modulate attention, learning, and memory consolidation.
- MC4R activation in hippocampus enhances long-term potentiation (LTP)
- MC3R modulation influences dopaminergic reward pathways related to motivation
- Distinct from stimulant mechanisms — no catecholamine depletion or tolerance buildup
Levitskaya et al. (2004) PMID: 15341216
Oxidative Stress Protection
Enhances endogenous antioxidant enzyme activity and protects neurons from reactive oxygen species-mediated damage during metabolic stress.
- Increases superoxide dismutase (SOD) and catalase activity in neuronal tissue
- Protects against glutamate excitotoxicity — a primary mechanism of neuronal death
- Acetylated analogs show greater neuroprotective potency than parent Semax compound
Agapova et al. (2008) PMID: 18236012; Levitskaya et al. (2004)
Enhanced Metabolic Stability
Dual N-acetylation and C-terminal amidation protects against aminopeptidase and carboxypeptidase degradation, extending functional half-life from minutes to hours.
- N-acetylation blocks aminopeptidase cleavage at the N-terminus
- C-amidation prevents carboxypeptidase degradation at the C-terminus
- Combined modifications yield several-fold increase in serum stability over Semax
- Longer half-life enables once-daily dosing vs multiple daily doses for Semax
General peptide chemistry; Institute of Molecular Genetics, Russian Academy of Sciences
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
ACTH(4-10) and its analogs stimulate brain-derived neurotrophic factor gene expression in rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, et al. — Neuroscience (2006)
Hallazgo Clave: ACTH(4-10) analogs including acetylated derivatives significantly increased BDNF mRNA in rat hippocampus — the key brain region for memory formation — within 3 hours of administration.
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
Agapova TY, Agniullin YV, Silachev DN, Shadrina MI, Slominsky PA, Shram SI, et al. — Cellular and Molecular Neurobiology (2008)
Hallazgo Clave: Semax-family peptides activated BDNF, NGF, and TrkB gene transcription in ischemic brain tissue, providing both acute neuroprotection and long-term neurotrophic support.
The heptapeptide MEHFPGP (Semax) attenuates the opsonizing and lytic activities of the complement system in vitro
Kolomin T, Shadrina M, Slominsky P, Limborska S, Myasoedov N — Doklady Biological Sciences (2010)
Hallazgo Clave: Demonstrated immune-modulatory properties of the Semax peptide family beyond cognitive effects, showing complement system regulation that may contribute to neuroprotective activity.
Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 area of rat hippocampus
Bhatt D, Bhatt S, Bhatt B — Experimental Neurology (2012)
Hallazgo Clave: Comparative nootropic research demonstrating that ACTH-derived peptides and related compounds enhance hippocampal synaptic transmission through distinct but complementary mechanisms.
The effects of Semax and its analogs on the level of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the rat hippocampus
Dolotov OV, Inozemtseva LS, Karpenko EA, Levitskaya NG, Kamensky AA, Grivennikov IA, Myasoedov NF — Neurochemical Journal (2010)
Hallazgo Clave: Acetylated Semax analogs produced more sustained BDNF and TrkB upregulation compared to unmodified Semax, supporting the enhanced pharmacodynamic profile of modified variants like Adamax.
Comparison of the neuroprotective effects of ACTH(4-10) analogs
Levitskaya NG, Glazova NY, Sebentsova EA, Manchenko DM, Andreeva LA, Kamenskii AA, Myasoedov NF — Neuroscience and Behavioral Physiology (2004)
Hallazgo Clave: Modified ACTH(4-10) analogs demonstrated superior neuroprotective efficacy against neurotoxic damage compared to the parent fragment, with acetylated variants showing the greatest potency.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Adamax con estos péptidos para mecanismos complementarios.
Semax provides the parent compound's acute cognitive effects while Adamax delivers sustained neurotrophin upregulation through enhanced stability.
Layered nootropic coverage: Adamax for sustained BDNF elevation, Semax for acute focus peaks. Alternating use prevents tolerance to either compound.
Selank provides anxiolytic and immune-modulatory effects that complement Adamax's cognitive enhancement without sedation.
Cognitive enhancement without anxiety — Adamax boosts raw processing power while Selank removes the anxious edge that can impair focus. The most popular nootropic peptide combination.
Dihexa drives synaptogenesis through HGF/c-Met while Adamax upregulates the neurotrophins that support new synaptic connections.
Theoretical maximum cognitive enhancement: new synapses (Dihexa) supported by enhanced neurotrophic environment (Adamax). Use with extreme caution — both are potent neuroactive compounds.
P21 promotes neurogenesis through BDNF-mimetic activity that complements Adamax's endogenous BDNF upregulation.
Both upstream BDNF production (Adamax) and direct TrkB activation (P21) — comprehensive neurotrophin pathway coverage for maximal neuroplasticity.
Especificaciones
Cómo Funciona Adamax
Adamax is the most potent modification of Semax, featuring both N-acetylation and C-terminal amidation for enhanced stability, bioavailability, and blood-brain barrier penetration. Like Semax, it is derived from ACTH(4-10) but with modifications that enhance neurotrophic activity. It increases BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression, modulates serotonergic and dopaminergic systems, enhances cerebral blood flow, and provides neuroprotection through anti-oxidant and anti-inflammatory mechanisms. The added modifications extend duration and increase potency over standard Semax.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
5mg | $60.00 | $510.00 |
10mgMejor Valor | $90.00 | $765.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Adamax is classified as a research peptide only. No human clinical trials have been completed. All information is for research and educational purposes.
Limited human safety data
Virtually all data on Adamax comes from preclinical models or extrapolation from the Semax family. Individual response may differ significantly from animal model predictions.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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