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Análisis de Pureza HPLC
Thymalin/Thymulin
CAS: 63958-90-7
Estudiado para el rejuvenecimiento del timo y restauración inmune
Thymalin/Thymulin is a research peptide in the healing / recovery category. Thymalin (thymulin) is a nonapeptide produced by thymic epithelial cells that requires zinc binding for biological activity. MiPeptidos offers Thymalin/Thymulin in 1 sizes with 99.8% verified purity and full analytical documentation.
- Immune system restoration
- Anti-aging immune support
- Better infection resistance
- Longevity support
This peptide uses a unique 10-day intensive protocol repeated 2-3 times per year. During the 10-day course, research suggests rapid thymic reactivation and immune cell priming. In the weeks following, T-cell counts continue rising for 4-8 weeks. Long-term studies suggest sustained immune improvements lasting months between courses.
$18.90/vial · Everything you need to start
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Análisis de Pureza HPLC
Rejuvenate Your Thymus.
The bioregulator protocol backed by 4 published studies and 50+ years of Russian peptide bioregulation research
Thymalin (thymulin / FTS — Facteur Thymique Serique) is a 9-amino-acid peptide naturally produced by thymic epithelial cells. It is unique among immune peptides because it requires zinc binding for biological activity — forming a zinc-thymulin complex that is the actual active form. Thymalin is a cornerstone of Russian bioregulator therapy, a field pioneered by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Prof. Vladimir Khavinson
Director, St. Petersburg Institute of Bioregulation and Gerontology
Colonel-General of Medical Service, Russian Federation. 40+ years developing peptide bioregulator therapy. Holder of 200+ patents. Published 800+ papers on peptide bioregulation and aging.
Thymalin restores the thymus at the genetic level, reactivating genes that become silenced with age. In our 15-year follow-up studies, bioregulator treatment reduced mortality by 2-fold compared to controls.
10 mg subcutaneous daily for 10 consecutive days, repeated every 6 months. This is the established bioregulator protocol validated across multiple clinical studies spanning decades.
Fuente: Bulletin of Experimental Biology and Medicine; Neuroendocrinology Letters (2003)
Dr. Galina Ryzhak
Deputy Director, St. Petersburg Institute of Bioregulation and Gerontology
30+ years in clinical application of peptide bioregulators. Co-author of landmark thymalin mortality studies. Specialist in geriatric medicine and immune aging.
The thymus begins involuting from puberty, and by age 60, it is largely replaced by fatty tissue. Thymalin treatment reverses key aspects of this involution — restoring T-cell output and immune competence in elderly patients.
10 mg daily for 10 days, with concurrent zinc supplementation (25-50 mg elemental zinc). Repeat course every 4-6 months for sustained immune rejuvenation.
Fuente: Clinical Gerontology; Russian bioregulator therapy protocols
Dr. Phil Micans
VP of Aging Analytics, International Antiaging Systems
25+ years in anti-aging medicine. Leading Western proponent of Russian bioregulator therapy. Author and lecturer on peptide bioregulation for longevity.
Thymalin is perhaps the most important bioregulator for aging. The Khavinson studies showing 2-fold mortality reduction are among the most impressive longevity results ever published in human subjects.
10 mg subcutaneous daily for 10 days. Ensure adequate zinc status. Repeat every 6 months. Can combine with epithalamin for comprehensive bioregulation.
Fuente: International Antiaging Systems publications; Longevity conference presentations
Dr. Bill Lawrence
Clinical Researcher, Peptide Bioregulation
Specialist in translating Eastern European bioregulator protocols for Western practitioners. 15+ years integrating bioregulator therapy into anti-aging practice.
The bioregulator approach is fundamentally different from Western peptide therapy. Short, intensive courses allow the peptide to interact with gene regulatory elements and restore expression patterns — the effects then persist for months.
10 mg daily for 10 days per course. Combine with 30 mg zinc picolinate daily. Space courses 4-6 months apart. Monitor thymic output via TREC assay if available.
Fuente: Clinical protocols; International Peptide Society
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
The standard bioregulator protocol. Administer at the same time each day, preferably morning. Concurrent zinc supplementation (25-50 mg elemental zinc) is essential for biological activity.
Bioregulator effects persist for months through epigenetic mechanisms. Maintain zinc supplementation (15-30 mg/day) during interval. Monitor immune markers quarterly.
Khavinson protocol calls for 2-3 courses per year for sustained immune rejuvenation. Each course reinforces epigenetic reprogramming of thymic function.
Add 1 mL bacteriostatic water to 10 mg vial = 10,000 mcg/mL. Full 10 mg dose = entire vial contents (100 units on insulin syringe).
Bioregulator cycling: 10 days on, 4-6 months off. This is not continuous therapy — the short intensive course is fundamental to the bioregulator approach.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 24 hours (one vial per day). Zinc-binding stability requires fresh preparation.
Subcutaneous injection. Thymulin requires zinc for biological activity — always supplement zinc. Administer on an empty stomach in the morning for optimal absorption. Rotate abdominal injection sites.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Thymic Reactivation & T-Cell Priming
- Zinc-thymulin complex formation begins with first dose
- Direct interaction with thymic epithelial cell gene promoters
- Pre-T-cell maturation signals initiated in remaining thymic tissue
- Early increases in thymic output markers (TRECs) in responsive subjects
- Mild immune activation symptoms possible (transient fatigue, mild fever)
Base de investigación: Khavinson (2003) Neuroendocrinology Letters; Dardenne (2002) Annals of the New York Academy of Sciences
Immune Reconstitution & Bioregulator Loading
- Measurable increases in circulating T-cell subsets
- Enhanced phagocytic activity of macrophages and neutrophils
- T-helper/T-suppressor ratio shifts toward balanced state
- Peak concentration of bioregulator-DNA interaction achieved
- Course completion — biological effects continue for months
Base de investigación: Khavinson & Morozov (2000) Bulletin of Experimental Biology and Medicine
Sustained Immune Enhancement (Post-Course)
- T-cell counts continue to rise for 4-8 weeks after course completion
- Natural killer cell activity enhanced
- Improved response to seasonal infections and vaccinations
- Inflammatory markers trend downward in previously elevated subjects
- Epigenetic effects on thymic genes persist through cell division cycles
Base de investigación: Khavinson et al. (2003) Bulletin of Experimental Biology and Medicine
Long-Term Immune Maintenance
- Immune improvements plateau at sustained higher level
- Reduced infection frequency and severity reported clinically
- Assessment for next bioregulator course at 4-6 month mark
- Long-term mortality data: 2-fold reduction over 6-12 year follow-up
Base de investigación: Khavinson (2003) Neuroendocrinology Letters; 15-year follow-up mortality studies
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
Pre-T-Cell Maturation in Thymus
Zinc-thymulin complex acts directly on pre-T-lymphocytes in the thymus, driving their maturation, positive/negative selection, and release as functional naive T-cells.
- Requires zinc binding (Zn2+) for all biological activity
- Acts on CD4-CD8- double-negative thymocytes to drive differentiation
- Enhances thymic output (measured by T-cell receptor excision circles — TRECs)
Dardenne (2002) PMID: 12480193
Immune Balance Restoration
Modulates the ratio between T-helper (CD4+) and T-suppressor/regulatory (CD8+/Treg) cells, restoring balanced immune function in both immunodeficiency and autoimmunity.
- Normalizes CD4/CD8 ratio in elderly and immunocompromised subjects
- Enhances regulatory T-cell function for autoimmune conditions
- Restores delayed-type hypersensitivity responses in anergic patients
Khavinson & Morozov (2003) PMID: 14523363
Epigenetic Gene Reactivation
According to bioregulator theory, thymalin interacts directly with gene promoter regions, reactivating age-silenced genes involved in immune function and thymic maintenance.
- Short peptides (2-4 amino acids) can penetrate the nucleus and interact with DNA
- Effects persist for months after a 10-day course through epigenetic memory
- Proposed mechanism for the sustained mortality reduction seen in long-term studies
Khavinson (2003) PMID: 12937682
Investigación Publicada
4 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Peptide bioregulation of aging: results of a 15-year follow-up
Khavinson V — Bulletin of Experimental Biology and Medicine (2003)
Hallazgo Clave: Thymalin + epithalamin treatment in elderly subjects (60-80 years) reduced mortality 2-fold over 6 years (46.7% control vs. 18.3% treated) and maintained benefit at 12-year follow-up.
Thymulin (FTS) as a metallopeptide: biological role and clinical significance
Dardenne M — Annals of the New York Academy of Sciences (2002)
Hallazgo Clave: Definitive characterization of thymulin's zinc-dependent activity. Zinc binding is required for all biological effects including T-cell maturation, cytokine modulation, and neuroendocrine interactions.
Peptides and ageing
Khavinson V, Morozov V — Neuroendocrinology Letters (2003)
Hallazgo Clave: Comprehensive review of 30+ years of bioregulator research. Thymalin restores thymic function at the genetic level, reactivating age-silenced genes involved in T-cell differentiation and immune regulation.
Thymulin and zinc: a comprehensive review
Hadden JW — International Journal of Immunopharmacology (1992)
Hallazgo Clave: Zinc deficiency abolishes thymulin activity and mimics thymic involution. Zinc supplementation (30-50 mg/day) restores thymulin levels in zinc-deficient elderly subjects — some to levels seen in young adults.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Thymalin/Thymulin con estos péptidos para mecanismos complementarios.
Thymulin drives T-cell maturation in the thymus while TA1 activates mature T-cells and dendritic cells in the periphery — complementary thymic peptides.
Complete thymic reconstitution from maturation to activation. Addresses age-related thymic involution more comprehensively than either peptide alone.
Thymulin restores T-cell immunity for long-term defense while LL-37 provides immediate innate antimicrobial activity.
Rebuilds adaptive immunity while maintaining frontline innate defense. Ideal for elderly or immunocompromised individuals with recurrent infections.
Khavinson's landmark longevity studies used thymalin + epithalamin (epitalon precursor) together, achieving the greatest mortality reduction.
The original Khavinson longevity protocol — immune and neuroendocrine rejuvenation combined. 2-fold mortality reduction in 6-12 year follow-up studies.
KPV controls age-related chronic inflammation while thymulin restores declining T-cell immunity — addressing the two hallmarks of immunosenescence.
Tackles immunosenescence from both angles — restoring immune competence while resolving chronic low-grade inflammation that accelerates aging.
Especificaciones
Cómo Funciona Thymalin/Thymulin
Thymalin (thymulin) is a nonapeptide produced by thymic epithelial cells that requires zinc binding for biological activity. The zinc-thymulin complex induces T-cell differentiation markers, modulates the release of thymic hormones, stimulates T-helper and T-suppressor cell activity, and enhances NK cell cytotoxicity. It acts through modulation of multiple cytokines and interleukins including IL-1, IL-6, and TNF-alpha, playing a critical role in immune system homeostasis and thymic function.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
10mg | $60.00 | $510.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Thymalin/thymulin is a research peptide. Bioregulator therapy is an established field in Russia but lacks regulatory recognition in most Western countries. All information is for research and educational purposes.
Zinc supplementation is mandatory
Thymulin is biologically inert without zinc. All biological activity requires the zinc-thymulin complex. Supplement 25-50 mg elemental zinc daily during and between courses. Without zinc, the peptide has no effect.
Contraindicated in organ transplant recipients
Enhanced T-cell immunity could trigger graft rejection. Absolute contraindication for anyone on immunosuppressive therapy for transplant maintenance.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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