TB500 Research Brief

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Literature SummaryHPLC DataPMIDs + CitationsEN + ES

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HPLC Purity Analysis

High-Performance Liquid Chromatography

99.8%purity

Method: RP-HPLC C18|UV 220nm|ACN/H₂O + 0.1% TFA

Healing / Recovery

TB500

Name: TB500
Brand: MiPeptidos
Availability: InStock

CAS: 77591-33-4 (Thymosin Beta-4); 885340-08-9 (synthetic TB-500 fragment)

Studied for cell migration, angiogenesis, and tissue-repair signaling

TB500 is a research peptide in the healing / recovery category. It is a thymosin beta-4 fragment studied for cell migration, angiogenesis, and tissue-repair signaling in published laboratory literature. MiPeptidos offers TB500 in 3 sizes with 99.8% verified purity and full analytical documentation.

Actin dynamics and cell migration
Angiogenesis and vascular signaling
Inflammatory pathway research
Soft-tissue and remodeling models

Research context only

The material summarized on this page comes from published laboratory, animal, and investigational literature. It does not establish safety or efficacy in humans, and TB500 is offered for research use only.

Frequently Bought Together

Bacteriostatic Water

Required for reconstitution

$10.00

BPC 157

Healing / Recovery

$40.00

Starting at

$37.95/vial$50.00

SALE — 24% OFF

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≥99% Purity

COA Included

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TB500 Research Brief

Free download — literature summary PDF

Literature SummaryHPLC DataPMIDs + CitationsEN + ES

No spam. Unsubscribe anytime.

HPLC Purity Analysis

High-Performance Liquid Chromatography

99.8%purity

Method: RP-HPLC C18|UV 220nm|ACN/H₂O + 0.1% TFA

CoA Included

|HPLC Verified

|GMP Compliant

|Third-Party Tested

|Same-Day Shipping

|Batch Tracked

Published literature

What the literature has actually examined

TB500 shows up in repair-focused literature because researchers have examined it across wound, ocular, cardiac, and connective-tissue models. The useful question is not hype. It is what the published work actually looked at.

Dermal wound models

Published studies have examined wound closure, collagen deposition, and neovascularization in rodent dermal models.

Corneal repair models

Ocular literature has reported epithelial migration and inflammatory-signaling changes in corneal injury models.

Cardiac injury research

Cardiac repair studies have explored survival and migration pathways after ischemic injury.

Fibrosis and remodeling

Researchers have also examined scar formation, tissue organization, and extracellular remodeling signals.

Study highlights

Malinda et al. (1999)

PMID 10390029

Dermal wound literature reported higher vessel density, collagen deposition, and faster closure in preclinical models.

Sosne et al. (2007)

PMID 17553493

Corneal work examined inflammatory markers and epithelial migration during wound repair.

Bock-Marquette et al. (2004)

PMID 15356633

Cardiac injury research explored ILK-linked survival and migration signaling after ischemic damage.

Philp et al. (2004)

PMID 15677412

Review literature synthesized TB4's role in angiogenesis, remodeling, and broad tissue-repair biology.

Specifications

Purity

≥99%

Form

Lyophilized Powder

CAS

77591-33-4 (Thymosin Beta-4); 885340-08-9 (synthetic TB-500 fragment)

Mol. Weight

4963.44 Da (full Thymosin Beta-4)

How TB500 Works

TB-500 (synthetic thymosin beta-4) is studied for its role in actin dynamics, a core process that helps cells migrate, reorganize, and respond to repair signals. Published literature has examined its interaction with angiogenic signaling, inflammatory pathways, and tissue-remodeling biology across multiple preclinical models. The active region LKKTETQ is considered central to its actin-binding activity.

Research Applications

Dermal wound-repair biology models

Cardiac injury and migration signaling research

Inflammatory pathway and remodeling studies

Corneal repair models

Connective-tissue and fibrosis research

View Published Research on PubMed →

Pricing

Size	Per Vial	10-Pack	Savings
2mgSale	$37.95$50.00	$379.50	24% off
5mgSale	$38.95$70.00	$389.50	44% off
10mgBest ValueSale	$99.95$120.00	$999.50	17% off

10-pack pricing shown. Volume discounts for 50+ vials — contact us.

Certificate of Analysis

MiPeptidos

TB500

PASSES ALL SPECIFICATIONS

Batch NumberHR-TB50-2600315

Date of AnalysisMarch 28, 2026

Purity (HPLC)99.8%

AppearanceWhite to off-white lyophilized powder

SolubilityFreely soluble in sterile water and bacteriostatic water

Molecular Weight (MS)4963.44 Da (full Thymosin Beta-4) — Confirmed

Endotoxin (LAL)<0.1 EU/mg

Sterility (USP <71>)Passes USP <71>

Download Full COA (PDF)

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every order.

Frequently Asked Questions

TB500 (CAS: 77591-33-4 for Thymosin Beta-4; 885340-08-9 for the synthetic TB-500 fragment) is a research compound in the Healing / Recovery category. Published literature has examined TB500 for its role in actin dynamics, cell migration, angiogenic signaling, and tissue-remodeling biology across preclinical models. Every vial from MiPeptidos includes batch-specific analytical documentation.

TB500 is available in 3 sizes (2mg, 5mg, 10mg), so reconstitution volume depends on vial size. For the 2mg size, add 1mL of bacteriostatic water; for the 10mg size, use 2-3mL. Let the vial come to room temperature first, add the water slowly along the vial wall, and swirl gently rather than shaking. Store reconstituted TB500 at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.

TB500 and BPC-157 appear together frequently in repair-focused literature, but they are studied through different mechanistic lenses. TB500 is examined in relation to actin dynamics and cell migration, while BPC-157 is commonly discussed in angiogenic and nitric-oxide-related pathways. Researchers often compare or pair them because the literature describes overlapping but non-identical research contexts.

Store lyophilized TB500 at -20°C for long-term stability. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. Published literature does not establish a precise TB500 half-life, so storage discipline matters for research consistency. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships with cold-chain packaging to help maintain integrity during transit.

Every TB500 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-TB50-2600315, tested March 28, 2026) shows 99.8% purity by HPLC, mass spectrometry confirmation at 4963.44 Da (full Thymosin Beta-4), endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This documentation helps researchers verify identity and purity before beginning lab work.

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.