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Análisis de Pureza HPLC
Semax
CAS: 80714-61-0
Neuropéptido estudiado para el enfoque y memoria mediados por BDNF
Semax is a research peptide in the cognitive / neuropeptides category. Semax is a synthetic heptapeptide analog of ACTH(4-10) with a stabilizing Pro-Gly-Pro extension. MiPeptidos offers Semax in 2 sizes with 99.3% verified purity and full analytical documentation.
- Boosted BDNF levels
- Improved memory retention
- Enhanced attention span
- Mood and motivation lift
Research indicates improved focus, alertness, and information retention within the first week as BDNF expression increases. By weeks 3-4, research suggests peak improvements in working memory, verbal fluency, and learning speed. Weeks 5-8 bring sustained cognitive enhancement and neuroprotective benefits, with many studies reporting their sharpest mental performance.
$16.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Think Faster. Remember More.
8-week nootropic protocol backed by 25+ years of Russian clinical research and 6 peer-reviewed studies
Semax is a synthetic heptapeptide analog of ACTH(4-10) — the active fragment of adrenocorticotropic hormone responsible for cognitive effects independent of adrenal stimulation. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences by Nikolai Myasoedov and colleagues, Semax has been approved in Russia since 2001 for treatment of stroke, cognitive disorders, optic nerve atrophy, and as a general nootropic.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Nikolai Myasoedov
Chief Researcher, Institute of Molecular Genetics, Russian Academy of Sciences
Co-developer of Semax. Lead researcher on ACTH-derived neuropeptides for over 30 years. Holds multiple patents on Semax and its analogs.
Semax represents a new class of nootropic drugs based on regulatory peptides. It has a unique combination of nootropic, neuroprotective, and neurotrophic activity that has been confirmed in extensive clinical practice.
Standard nootropic dose ~600 mcg/day subcutaneously, split into 2-3 doses. For acute neuroprotection: higher doses under supervision. 10-14 day treatment courses.
Fuente: Institute of Molecular Genetics, Russian Academy of Sciences
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab podcast. Expert in BDNF, neuroplasticity, and visual system neuroscience.
BDNF is the key molecule for neuroplasticity — it strengthens existing synapses and promotes the formation of new ones. Compounds that reliably increase BDNF in the hippocampus have enormous implications for learning and memory.
Focus on BDNF upregulation as the primary cognitive mechanism. Combine with behavioral interventions that also boost BDNF: exercise, novel learning, and adequate sleep.
Fuente: Huberman Lab Podcast: BDNF & Neuroplasticity episodes (2023-2024)
Dr. Neil Paulvin
Functional & Regenerative Medicine Physician, Manhattan
Known as 'Dr. Peptide.' Integrates Russian neuropeptide research into Western functional medicine. Treats high-performance individuals seeking cognitive optimization.
Semax is one of the best-studied nootropic peptides we have. It's approved in Russia, used by hundreds of thousands of people, and has a remarkably clean safety profile. It's my go-to for patients who want pure cognitive enhancement.
300-600 mcg/day subcutaneously for cognitive enhancement. Can titrate up to 900 mcg/day for acute cognitive demand. Pairs exceptionally well with Selank for anxious high-performers.
Fuente: Clinical practice; MindHack Podcast
Dr. William Seeds
Founder, SSRP Institute
40+ years in cellular and molecular medicine. Author of 'Peptide Protocols: Volume 1'. Expert in clinical peptide therapy applications.
The ACTH-derived nootropic peptides like Semax offer a mechanistically clean approach to cognitive enhancement — neurotrophin upregulation rather than neurotransmitter flooding. This is sustainable cognitive improvement.
200-600 mcg subcutaneously per day. Standard 4-8 week cycles. Monitor for overstimulation at higher doses. Combine with Selank for balanced nootropic-anxiolytic protocols.
Fuente: Peptide Protocols: Volume 1 (ISBN: 978-0578624358)
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Start conservatively. Semax has a very short serum half-life (~3-5 min) but CNS effects persist for hours after subcutaneous delivery. Rotate injection sites. Morning dosing recommended for daytime cognitive benefit.
Matches the Russian-approved dosing regimen. Multiple daily doses compensate for the short half-life. Rotate injection sites between abdominal quadrants. Peak BDNF upregulation and cognitive effects during this phase.
Taper to assess sustained neuroplastic benefits. Russian clinical protocols often use 10-14 day courses; Western practitioners typically extend to 4-8 weeks. Plan 2-4 week washout.
Add 1 mL bacteriostatic water to 5 mg vial = 5,000 mcg/mL. Use an insulin syringe for precise subcutaneous dosing. 200 mcg = 4 units (0.04 mL); 600 mcg = 12 units (0.12 mL).
Russian clinical standard: 10-14 day courses with 10-14 day intervals. Western practitioners: 4-8 weeks on, 2-4 weeks off. Semax shows minimal tolerance development but cycling maintains optimal melanocortin receptor responsiveness.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 30 days. Protect from light and heat.
Subcutaneous injection into the abdominal fat pad is the recommended route. Use a 29-31 gauge insulin syringe. Pinch a fold of skin, insert at a 45-degree angle, and inject slowly. Rotate injection sites between abdominal quadrants to prevent lipodystrophy.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Neurotrophin Activation & Initial Cognitive Lift
- BDNF gene expression begins increasing in hippocampus within hours of first dose
- Subtle improvement in focus, attention, and mental clarity within 3-7 days
- Enhanced alertness without stimulant-like jitteriness or cardiovascular effects
- Initial mood improvement as melanocortin receptor activation modulates dopamine
- Studies report improved information retention during study or work sessions
Base de investigación: Dolotov et al. (2006) Neuroscience PMID: 16413131; Agapova et al. (2008) Cell Mol Neurobiol
Peak BDNF Upregulation & Memory Enhancement
- BDNF and TrkB upregulation reaches peak levels with consistent dosing
- Noticeable improvements in working memory and verbal fluency
- Enhanced learning speed for new material and skill acquisition
- Neuroprotective effects established — resilience against cognitive fatigue
- Gene expression changes in over 24 functional gene groups documented
Base de investigación: Agapova et al. (2008) PMID: 18236012; Gusev et al. (2008) Genetika
Sustained Enhancement & Neuroprotection
- Stable cognitive enhancement plateau at therapeutic doses
- Maximal neuroprotective status against oxidative and ischemic stress
- Executive function improvements — better planning and decision-making
- Enhanced pattern recognition and creative problem-solving ability
- Possible improvements in visual acuity (established clinical application in Russia)
Base de investigación: Russian clinical data; Kaplan et al. (2015) J Neurol Sci; Semax product monograph
Consolidation & Post-Cycle Assessment
- Taper dosing to evaluate sustained neuroplastic changes
- Many cognitive benefits persist 2-4 weeks after discontinuation
- Structural synaptic changes from BDNF upregulation are semi-permanent
- Plan 2-4 week washout; some practitioners alternate with Selank during wash periods
Base de investigación: General neurotrophin biology; BDNF-mediated structural plasticity literature
Mecanismo de Acción
4 vías biológicas distintas a través de las cuales opera este péptido.
BDNF & Neurotrophin Upregulation
Potently stimulates transcription and translation of BDNF, NGF, and their receptors TrkB and TrkC in hippocampus and cortex — the molecular basis for enhanced learning and memory.
- BDNF mRNA increased in hippocampus within 3 hours of administration
- TrkB receptor co-upregulated — amplifying downstream signaling cascades
- NGF also elevated — supporting cholinergic neuronal health critical for memory
- Effects persist well beyond the peptide's serum half-life due to transcriptional activation
Dolotov et al. (2006) PMID: 16413131; Agapova et al. (2008) PMID: 18236012
Melanocortin Receptor Activation (MC3/MC4)
As an ACTH(4-10) analog, Semax activates melanocortin receptors MC3R and MC4R in the CNS, modulating attention, arousal, and memory consolidation.
- MC4R activation in hippocampus enhances long-term potentiation (LTP)
- Modulates dopaminergic signaling for improved motivation and reward-driven learning
- No adrenal stimulation — cognitive effects are independent of cortisol elevation
- Pro-Gly-Pro extension provides enzymatic stability without altering receptor selectivity
Levitskaya et al. (2004); General melanocortin receptor pharmacology
Neuroprotection Against Ischemia
Provides multi-pathway neuroprotection against ischemic and oxidative brain damage — the mechanism behind its Russian approval for stroke treatment.
- Counteracts ischemia-induced gene expression changes within 24 hours
- Restores anti-apoptotic gene programs suppressed by oxygen deprivation
- Enhances antioxidant enzyme activity (SOD, catalase) in neural tissue
- Reduces infarct volume and improves neurological outcomes in animal stroke models
Medvedeva et al. (2014) PMID: 25380972; Kaplan et al. (1996) PMID: 8953246
Broad Genomic Modulation
Whole-genome analysis reveals Semax modulates over 24 functional gene groups simultaneously — a remarkably broad mechanism explaining its diverse clinical effects.
- Neurotransmitter transport and receptor genes upregulated
- Immune response and inflammation resolution genes activated
- Vascular regulation and angiogenesis gene programs modulated
- Effect pattern explains why Semax has cognitive, neuroprotective, and immunomodulatory activities simultaneously
Gusev et al. (2008) Genetika; Medvedeva et al. (2014) PMID: 25380972
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
ACTH(4-10) and its analogs stimulate BDNF gene expression in rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, et al. — Neuroscience (2006)
Hallazgo Clave: Semax and related ACTH(4-10) analogs significantly increased BDNF mRNA in the hippocampus — the critical brain region for memory formation — within 3 hours of administration.
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
Agapova TY, Agniullin YV, Silachev DN, Shadrina MI, Slominsky PA, Shram SI, et al. — Cellular and Molecular Neurobiology (2008)
Hallazgo Clave: Semax activated transcription of BDNF, NGF, TrkB, and TrkC genes in ischemic brain tissue — providing both acute neuroprotection and long-term neurotrophic support after stroke.
Genome-wide analysis of Semax effect on gene expression in rat cortex
Gusev EI, Skvortsova VI, Myasoedov NF, Nezavibatko VN, Sychev AV, Poletaeva II, et al. — Genetika (Russian Journal of Genetics) (2008)
Hallazgo Clave: Whole-genome microarray analysis revealed Semax modulates over 24 functional gene groups in rat cerebral cortex, including neurotransmitter transport, immune response, and vascular regulation.
Selank and Semax increase the content of BDNF in rat hippocampus
Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Manuilova ES, et al. — Doklady Biological Sciences (2006)
Hallazgo Clave: Both Semax and Selank increased BDNF protein levels in rat hippocampus, providing direct molecular evidence for their nootropic mechanisms.
Neuroprotective effects of Semax in conditions of global cerebral ischemia
Kaplan AY, Kochetova AG, Nezavibathko VN, Rjasina TV, Ashmarin IP — Bulletin of Experimental Biology and Medicine (1996)
Hallazgo Clave: Semax significantly protected neurons against global ischemic damage, improving neurological outcomes and reducing infarct volume. Foundation data for its Russian approval in stroke treatment.
The effects of Semax on cerebral cortex gene expression in rats with experimental focal cerebral ischemia
Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, et al. — BMC Genomics (2014)
Hallazgo Clave: Transcriptomic analysis showed Semax counteracted ischemia-induced gene expression changes, particularly restoring immune response, neurotransmitter, and anti-apoptotic gene programs within 24 hours of treatment.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Semax con estos péptidos para mecanismos complementarios.
The classic Russian neuropeptide combination developed at the same institute. Semax provides cognitive enhancement while Selank provides anxiolysis — together, they deliver focused cognition without anxiety.
Russia's most prescribed nootropic combination. Calm, focused cognitive enhancement without the anxiety that can accompany pure nootropics or the sedation that accompanies anxiolytics.
Adamax is the enhanced-stability version of Semax. Using both allows acute Semax dosing for immediate cognitive needs plus Adamax for sustained neurotrophin support.
Complete neurotrophin coverage: Semax for acute cognitive peaks, Adamax for sustained baseline enhancement. Alternate rather than combine for optimal receptor management.
P21 promotes neurogenesis and acts as a BDNF mimetic, complementing Semax's endogenous BDNF upregulation through an independent pathway.
Dual neurotrophin strategy: endogenous BDNF production (Semax) plus direct TrkB activation (P21). Comprehensive support for both synaptic plasticity and new neuron formation.
Pinealon is a short bioregulator peptide that modulates pineal function and circadian neurotransmitter balance, complementing Semax's daytime cognitive enhancement.
24-hour cognitive optimization: Semax for daytime performance, Pinealon for nighttime neural restoration. Supports the sleep-dependent memory consolidation that locks in daytime learning.
Especificaciones
Cómo Funciona Semax
Semax is a synthetic heptapeptide analog of ACTH(4-10) with a stabilizing Pro-Gly-Pro extension. It increases BDNF and TrkB receptor expression, enhances neurotrophic factor signaling, modulates dopaminergic and serotonergic neurotransmission, and provides neuroprotection through antioxidant and anti-inflammatory mechanisms. Unlike ACTH, Semax has no steroidogenic activity. It improves cerebral circulation, enhances memory consolidation, and has been approved in Russia and Ukraine for stroke recovery and cognitive enhancement.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
5mg | $40.00 | $340.00 | — |
10mgMejor ValorOferta | $37.95$60.00 | $322.57 | 37% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Semax is approved in Russia as a nootropic and neuroprotective agent but is classified as a research peptide in the US and EU. All information is for research and educational purposes.
Limited Western clinical trial data
Extensive Russian clinical use (100,000+ patients) but minimal English-language controlled trials. Most evidence is from Russian literature, animal models, and mechanistic studies.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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