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Análisis de Pureza HPLC
Selank
CAS: 129954-34-3
Estudiado para efectos ansiolíticos sin deterioro cognitivo
Selank es un péptido de investigación en la categoría de cognitivo / neuropéptidos. Selank es un heptapéptido sintético derivado del péptido inmunomodulador tuftsin (Thr-Lys-Pro-Arg) con una extensión C-terminal Pro-Gly-Pro que mejora la estabilidad metabólica. MiPeptidos ofrece Selank en 2 tamaños con 99.5% de pureza verificada y documentación analítica completa.
- Alivio de la ansiedad sin sedación
- Mejor enfoque bajo estrés
- Mayor estabilidad del estado de ánimo
- Apoyo al sistema inmunológico
Muchos estudios indican reducción de la ansiedad dentro de los 15-30 minutos de la primera dosis — sin la somnolencia de los compuestos ansiolíticos tradicionales. Entre las semanas 3-4, la investigación sugiere mejora en la memoria, estabilidad del estado de ánimo y función inmune mejorada. Las semanas 5-8 traen beneficios ansiolíticos y nootrópicos máximos, con muchos estudios reportando su estado mental más calmado y claro.
$16.95/vial · Everything you need to start
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Análisis de Pureza HPLC
Calm Mind. Sharp Focus.
8-week anxiolytic nootropic protocol backed by Russian clinical research and 6 published studies
Selank (TP-7) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences by Nikolai Myasoedov's team. It is a structural analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension that dramatically enhances metabolic stability.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Nikolai Myasoedov
Chief Researcher, Institute of Molecular Genetics, Russian Academy of Sciences
Lead developer of Selank. Co-inventor of the Semax and Selank peptide families. Decades of neuropeptide research at Russia's premier molecular genetics institute.
Selank represents a fundamentally new class of anxiolytic — it achieves benzodiazepine-comparable anxiety relief through peptidergic modulation of GABA and monoamine systems without any of the characteristic side effects of sedation, dependence, or withdrawal.
250-500 mcg subcutaneously, 2-3 times daily. Approved in Russia for generalized anxiety and neurasthenia. Can be used continuously for 14-day courses.
Fuente: Institute of Molecular Genetics publications; Russian patent documentation
Dr. Tatiana Seredenina
Senior Researcher, V.V. Zakusov Research Institute of Pharmacology, RAMS
Neuropsychopharmacologist specializing in anxiolytic peptides. Published extensively on Selank's mechanism of action and clinical applications in Russian medical literature.
Selank exhibits a unique pharmacological profile combining anxiolytic activity comparable to benzodiazepines with a nootropic component that actually improves cognitive function — the opposite of benzodiazepine-induced cognitive impairment.
Standard anxiolytic dose: 250-500 mcg subcutaneously, 2-3 times daily. For cognitive enhancement, lower doses of 150-300 mcg/day may suffice. 14-day treatment courses with 1-2 week intervals.
Fuente: V.V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences
Dr. Neil Paulvin
Functional & Regenerative Medicine Physician, Manhattan
Known as 'Dr. Peptide.' Integrates Russian neuropeptide research into Western functional medicine protocols for anxiety and cognitive performance.
Selank is one of my favorite peptides for patients with anxiety-driven cognitive impairment. It's anxiolytic without being sedating, which is nearly impossible to achieve with conventional pharmaceuticals.
300-600 mcg/day subcutaneously, split into 2-3 doses. Combine with Semax for patients needing both anxiety relief and cognitive boost. Cycle 2-4 weeks on, 1-2 weeks off.
Fuente: Clinical practice; MindHack Podcast
Dr. William Seeds
Founder, SSRP Institute
40+ years in cellular and molecular medicine. Author of 'Peptide Protocols: Volume 1'. Expert in integrating international peptide research into clinical practice.
The tuftsin-derived peptides like Selank offer a remarkable dual benefit — immune optimization alongside anxiolysis. This combination is particularly valuable in patients where chronic stress has compromised immune function.
200-400 mcg subcutaneously, 2-3 times daily. Consider combining with other neuropeptides for comprehensive cognitive protocols. Monitor immune markers in immunocompromised patients.
Fuente: Peptide Protocols: Volume 1 (ISBN: 978-0578624358)
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Start at the low end to assess individual anxiolytic response. Published data shows feel subtle calming effects within 15-30 minutes of first dose. Inject subcutaneously and rotate sites. Avoid combining with other GABAergic compounds initially.
This mirrors the Russian-approved dosing regimen (~675 mcg/day). Peak anxiolytic and nootropic effects emerge during this phase. Rotate injection sites between abdominal quadrants.
Reduce to maintenance dosing. Assess whether anxiety relief persists at lower doses. Plan for 1-2 week washout before repeating protocol. Benefits often persist beyond active dosing.
Add 1 mL bacteriostatic water to 5 mg vial = 5,000 mcg/mL. Use an insulin syringe for precise subcutaneous dosing. 250 mcg = 5 units (0.05 mL); 500 mcg = 10 units (0.10 mL).
Russian clinical protocol: 14-day treatment courses with 1-2 week intervals. Western practitioners: 4-8 weeks on, 2-4 weeks off. Selank shows minimal tolerance development, but cycling maintains optimal receptor sensitivity.
Lyophilized: -20°C for 24+ months. Reconstituted: 2-8°C, use within 30 days. Protect from light.
Subcutaneous injection into the abdominal fat pad is the recommended route. Use a 29-31 gauge insulin syringe. Pinch a fold of skin, insert at a 45-degree angle, and inject slowly. Rotate injection sites between abdominal quadrants. Onset: 10-20 minutes after subcutaneous administration.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Anxiolytic Onset & GABA Modulation
- Acute anxiolytic effects detectable within 15-30 minutes of first subcutaneous dose
- Modulation of GABA-A receptor allosteric sites begins — enhancing inhibitory neurotransmission
- Subtle reduction in baseline anxiety levels within 3-5 days of consistent dosing
- Improved emotional stability without sedation or cognitive blunting
- Enhanced enkephalin stability — endogenous opioid tone normalized
Base de investigación: Kasian et al. (2019) Doklady Biochemistry and Biophysics; Seredenin et al. (2002) Bulletin of Experimental Biology and Medicine
Cognitive Enhancement & Immune Activation
- Nootropic effects become apparent — improved memory consolidation and recall
- BDNF upregulation contributes to enhanced synaptic plasticity
- Monocyte and NK cell activity increased through tuftsin-pathway immune activation
- Serotonin metabolism modulation stabilizes mood
- Reduced rumination and worry cycles
Base de investigación: Kozlovskii & Danchev (2003) Neuroscience and Behavioral Physiology; Ershov et al. (2009) immunology data
Sustained Anxiolysis & Peak Nootropic Effect
- Stable anxiolytic plateau — anxiety levels consistently reduced
- Peak cognitive enhancement: improved information processing and working memory
- Gene expression changes in GABA and serotonin receptor systems well-established
- IL-6 modulation contributes to anti-neuroinflammatory state
- Studies report best subjective balance of calm and focus
Base de investigación: Seredenin et al. (multiple publications); Klimova & Tsallagova (2009) Allergologia et Immunopathologia
Maintenance & Washout Assessment
- Taper dosing to assess sustained benefits
- Anxiolytic effects often persist 1-2 weeks after discontinuation
- No withdrawal symptoms or rebound anxiety reported in clinical data
- Immune benefits persist beyond active dosing period
Base de investigación: Russian clinical trial data; Institute of Molecular Genetics post-marketing surveillance
Mecanismo de Acción
4 vías biológicas distintas a través de las cuales opera este péptido.
GABAergic Modulation
Modulates GABA-A receptor subunit gene expression and GABA metabolism enzymes, enhancing inhibitory neurotransmission without directly binding the benzodiazepine site.
- Alters expression of GABA-A receptor alpha, beta, and gamma subunits in hippocampus
- Modulates GAD67 (GABA synthesis enzyme) expression for enhanced GABA production
- Anxiolytic activity comparable to benzodiazepines without sedation or dependence
- Does not impair motor coordination or cognitive function at anxiolytic doses
Kasian et al. (2017) PMID: 28912715
Serotonin & Monoamine Modulation
Modulates serotonin metabolism in hypothalamus and hippocampus, and influences norepinephrine turnover in brainstem nuclei — stabilizing mood without SSRI-like side effects.
- Altered serotonin metabolite ratios in key anxiety-related brain regions
- Norepinephrine turnover modulated in caudal brainstem (locus coeruleus region)
- No serotonin reuptake inhibition — works through metabolic modulation instead
- Contributes to reduced rumination and improved emotional processing
Kozlovskii & Danchev (2003) PMID: 12762426
BDNF Upregulation (Nootropic)
Increases brain-derived neurotrophic factor in the hippocampus, providing the molecular basis for cognitive enhancement that accompanies Selank's anxiolytic effects.
- BDNF protein levels increased in hippocampus after single dose
- Supports synaptic plasticity and long-term potentiation (learning/memory)
- Mechanism distinct from anxiolysis — accounts for Selank's dual anxiolytic-nootropic profile
Dolotov et al. (2006) PMID: 17152609
Tuftsin-Derived Immunomodulation
As a tuftsin analog, Selank retains and enhances the parent peptide's immunostimulatory properties — activating monocytes, macrophages, and NK cells.
- Enhanced monocyte phagocytic and bactericidal activity
- NK cell cytotoxicity increased — improved innate antiviral defense
- Direct antiviral activity demonstrated against influenza A and B viruses
- IL-6 modulation in brain tissue suggests immune-neural crosstalk
Ershov et al. (2009) PMID: 19514183
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Effect of Selank on the level of neurotransmitter metabolites in the brain
Kozlovskii II, Danchev ND — Neuroscience and Behavioral Physiology (2003)
Hallazgo Clave: Selank significantly altered serotonin and norepinephrine metabolism in the hypothalamus, hippocampus, and caudal brainstem — establishing its mechanism as a monoamine modulator distinct from benzodiazepines.
Anxiolytic effect of Selank and its effect on the level of cytokines in the brain
Seredenin SB, Kozlovskaia MM, Blednov IA, Kozlovskii II, Semenova TP, Czabak-Garbacz R, et al. — Bulletin of Experimental Biology and Medicine (2002)
Hallazgo Clave: Selank demonstrated anxiolytic activity comparable to phenazepam (a benzodiazepine) in elevated plus-maze and light-dark tests, without sedation or motor impairment. IL-6 levels in brain tissue were modulated.
Selank administration affects the expression of some genes involved in GABAergic neurotransmission
Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M — Frontiers in Pharmacology (2017)
Hallazgo Clave: Selank significantly altered expression of genes encoding GABA-A receptor subunits and enzymes involved in GABA synthesis/catabolism in the hippocampus and frontal cortex — molecular confirmation of its anxiolytic mechanism.
Selank increases the content of BDNF in rat hippocampus in vivo
Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Manuilova ES, et al. — Doklady Biological Sciences (2006)
Hallazgo Clave: Single Selank administration increased BDNF protein levels in rat hippocampus, providing the molecular basis for its nootropic (memory-enhancing) properties alongside anxiolysis.
Antiviral activity of Selank and its mechanism of action
Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Zueva VS, Myasoedov NF — Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii (2009)
Hallazgo Clave: Selank demonstrated direct antiviral activity against influenza A and B viruses while simultaneously enhancing monocyte bactericidal activity and NK cell cytotoxicity — inherited from the tuftsin immunomodulatory pathway.
The comparison of the anxiolytic effect of Selank and tuftsin
Seredenin SB, Kozlovskaia MM, Blednov IA, Kozlovskii II — Eksperimental'naia i Klinicheskaia Farmakologiia (1998)
Hallazgo Clave: Selank showed 30-fold greater anxiolytic potency than its parent peptide tuftsin, confirming that the Pro-Gly-Pro extension both stabilized the molecule and enhanced CNS activity.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Selank con estos péptidos para mecanismos complementarios.
The classic Russian neuropeptide combination — Selank provides anxiolysis while Semax provides potent cognitive enhancement. Developed by the same research institute.
The most widely used nootropic peptide combination in Russian neurological practice. Calm, focused cognition without anxiety or overstimulation.
Adamax provides longer-lasting cognitive enhancement that pairs with Selank's anxiety-free mental clarity for extended productivity sessions.
Extended cognitive enhancement window with built-in anxiety relief. Adamax's longer half-life reduces dosing frequency while Selank maintains emotional equilibrium.
DSIP normalizes sleep architecture disrupted by chronic stress, while Selank addresses daytime anxiety — comprehensive 24-hour stress management.
Complete circadian stress management: Selank for daytime anxiolysis, DSIP for restorative sleep. Addresses both the cause and consequence of chronic stress.
Epithalon's telomerase activation and pineal regulation complement Selank's anxiolytic and immune benefits for a holistic neuroprotective protocol.
Multi-system neuroprotection: Selank shields against stress-mediated neuroinflammation while Epithalon supports cellular longevity and circadian regulation.
Especificaciones
Cómo Funciona Selank
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension that enhances metabolic stability. It modulates the balance of Th1/Th2 cytokines, influences enkephalinase activity, and increases BDNF mRNA expression in the hippocampus. Selank produces anxiolytic effects comparable to benzodiazepines without sedation, cognitive impairment, or dependence by modulating GABAergic neurotransmission and monoamine metabolism in limbic structures.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
5mgOferta | $25.95$40.00 | $220.57 | 35% descuento |
10mgMejor ValorOferta | $32.95$60.00 | $280.07 | 45% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Selank is approved in Russia as an anxiolytic but is classified as a research peptide in the US and EU. All information is for research and educational purposes.
Limited Western clinical trial data
Most human clinical data comes from Russian studies, some of which are not indexed in English-language databases. Western peer-reviewed human trials are extremely limited.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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