Selank vs Semax
Compare Selank and Semax, two Russian-developed nootropic peptides with distinct neurological mechanisms. One excels in anxiolytic research, the other in cognitive enhancement and BDNF upregulation.
Selank
Cognitive / Neuropeptides
Semax
Cognitive / Neuropeptides
Side-by-Side Comparison
Derived from immunomodulatory tuftsin with Pro-Gly-Pro extension; modulates Th1/Th2 cytokine balance, increases BDNF mRNA in hippocampus, produces anxiolytic effects via GABAergic modulation without sedation
Derived from ACTH(4-10) with Pro-Gly-Pro extension; increases BDNF and TrkB receptor expression, modulates dopaminergic and serotonergic systems, provides neuroprotection, improves cerebral circulation
GABA receptors, enkephalinase, Th1/Th2 cytokine pathways, monoamine systems
BDNF/TrkB pathways, dopaminergic and serotonergic systems, melanocortin-related
~3-5 minutes in serum; functional CNS effects last hours
~3-5 minutes in serum; CNS effects persist for hours
Typically studied 1-3x daily (intranasal or injection)
Typically studied 1-3x daily (intranasal or injection)
Anxiety reduction without sedation, immune modulation via tuftsin pathway, cognitive enhancement and memory, GABA and monoamine system modulation, nootropic pharmacology
Cognitive enhancement and memory consolidation, stroke recovery and neuroprotection, BDNF and neurotrophin pathway upregulation, attention deficit and cognitive disorders, cerebrovascular protection
751.89 Da (heptapeptide)
813.92 Da (heptapeptide)
$16.95/vial (5mg)
$16.95/vial (5mg)
Derived from immunomodulatory tuftsin with Pro-Gly-Pro extension; modulates Th1/Th2 cytokine balance, increases BDNF mRNA in hippocampus, produces anxiolytic effects via GABAergic modulation without sedation
Derived from ACTH(4-10) with Pro-Gly-Pro extension; increases BDNF and TrkB receptor expression, modulates dopaminergic and serotonergic systems, provides neuroprotection, improves cerebral circulation
GABA receptors, enkephalinase, Th1/Th2 cytokine pathways, monoamine systems
BDNF/TrkB pathways, dopaminergic and serotonergic systems, melanocortin-related
~3-5 minutes in serum; functional CNS effects last hours
~3-5 minutes in serum; CNS effects persist for hours
Typically studied 1-3x daily (intranasal or injection)
Typically studied 1-3x daily (intranasal or injection)
Anxiety reduction without sedation, immune modulation via tuftsin pathway, cognitive enhancement and memory, GABA and monoamine system modulation, nootropic pharmacology
Cognitive enhancement and memory consolidation, stroke recovery and neuroprotection, BDNF and neurotrophin pathway upregulation, attention deficit and cognitive disorders, cerebrovascular protection
751.89 Da (heptapeptide)
813.92 Da (heptapeptide)
$16.95/vial (5mg)
$16.95/vial (5mg)
Detailed Breakdown
Mechanism
Derived from immunomodulatory tuftsin with Pro-Gly-Pro extension; modulates Th1/Th2 cytokine balance, increases BDNF mRNA in hippocampus, produces anxiolytic effects via GABAergic modulation without sedation
Derived from ACTH(4-10) with Pro-Gly-Pro extension; increases BDNF and TrkB receptor expression, modulates dopaminergic and serotonergic systems, provides neuroprotection, improves cerebral circulation
Receptor Targets
GABA receptors, enkephalinase, Th1/Th2 cytokine pathways, monoamine systems
BDNF/TrkB pathways, dopaminergic and serotonergic systems, melanocortin-related
Half-Life
~3-5 minutes in serum; functional CNS effects last hours
~3-5 minutes in serum; CNS effects persist for hours
Dosing Frequency
Typically studied 1-3x daily (intranasal or injection)
Typically studied 1-3x daily (intranasal or injection)
Research Applications
Anxiety reduction without sedation, immune modulation via tuftsin pathway, cognitive enhancement and memory, GABA and monoamine system modulation, nootropic pharmacology
Cognitive enhancement and memory consolidation, stroke recovery and neuroprotection, BDNF and neurotrophin pathway upregulation, attention deficit and cognitive disorders, cerebrovascular protection
Molecular Weight
751.89 Da (heptapeptide)
813.92 Da (heptapeptide)
Starting Price
$16.95/vial (5mg)
$16.95/vial (5mg)
Which Is Right for Your Research?
Choose Selank for anxiolytic and immune-modulation research via GABAergic pathways without sedation or dependence. Choose Semax for cognitive enhancement, memory consolidation, and BDNF/neurotrophin upregulation research.