Retatrutide - Front - MiPeptidos
GLP-1 / Weight Management

Retatrutide

CAS: 2381089-83-2

Retatrutide is a research peptide in the glp-1 / weight management category. Retatrutide is a triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon (GCGR) receptors. MiPeptidos offers Retatrutide in 6 sizes with 99.4% verified purity and full analytical documentation.

Starting at
$41.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How Retatrutide Works

Retatrutide is a triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon (GCGR) receptors. GLP-1 and GIP agonism drive insulin secretion and appetite suppression, while glucagon receptor activation increases energy expenditure and hepatic lipid oxidation. This triple mechanism addresses multiple metabolic pathways for potentially superior weight loss and metabolic improvement over dual agonists.

Research Applications

1
Obesity with extreme weight loss potential (>24% in trials)
2
Type 2 diabetes management
3
Triple incretin receptor pharmacology
4
Hepatic fat reduction and NASH
5
Energy expenditure and thermogenesis research
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$41.95$305.95
10mg
$71.95$524.95
15mg
$98.95$721.95
20mg
$125.95$918.95
30mg
$184.95$1349.95
60mgBest Value
$329.95$2408.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.4%purity
mAURetention Time (min)0250500750100005101520253099.4%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
Retatrutide
PASSES ALL SPECIFICATIONS
Batch NumberHR-RTTR-2600315
Date of AnalysisMarch 12, 2026
Purity (HPLC)99.4%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)4731.41 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg Retatrutide + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed Retatrutide product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Researcher Reviews

4.7/5from 3 reviews
Verified
Dr. Anja Petersen·Copenhagen, Denmark

Triple agonist peptides are notoriously difficult to synthesize at high purity. MiPeptidos retatrutide hit 98.7% on our ESI-MS verification, which is outstanding for a GLP-1/GIP/glucagon tri-agonist. Shipped to Denmark i...

Feb 22, 2026
Verified
Raj Mehta·Boston, MA

Our obesity research group has tested retatrutide from three different suppliers and MiPeptidos is the clear winner on purity and consistency. The tri-agonist activity profile in our in vitro models aligns perfectly with...

Jan 8, 2026
Verified
Angela Chen·Singapore

Retatrutide quality is superb for a tri-agonist peptide with this level of synthetic complexity. Our glucagon receptor activation data matches published profiles perfectly. Four stars because shipping to Singapore took t...

Nov 2, 2025
View All Reviews →

Frequently Asked Questions

Retatrutide (CAS: 2381089-83-2) is a research compound, with a molecular weight of 4731.41 Da in the GLP-1 / Weight Management category. Retatrutide is a triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon (GCGR) receptors. GLP-1 and GIP agonism drive insulin secretion and appetite suppression, while glucagon receptor activation increases energy expenditure and hepatic lipid oxidation. Researchers commonly investigate Retatrutide for Obesity with extreme weight loss potential (>24% in trials), Type 2 diabetes management, Triple incretin receptor pharmacology. Every vial from MiPeptidos includes batch-specific analytical documentation.
Retatrutide is available in 6 sizes (5mg, 10mg, 15mg, 20mg, 30mg, 60mg), so reconstitution volume depends on which vial you have. For the 5mg size, add 1-2mL of bacteriostatic water; for the 60mg size, use 6-8mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted Retatrutide at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
Retatrutide is a triple agonist hitting GLP-1, GIP, and glucagon receptors simultaneously, while Tirzepatide only targets GLP-1 and GIP. That third glucagon receptor arm drives hepatic lipid oxidation and thermogenesis, which is why Phase 2 data showed Retatrutide achieving up to 24% body weight reduction — exceeding what dual agonists have demonstrated. MiPeptidos carries both compounds for researchers interested in comparing dual vs triple incretin receptor pharmacology.
Store lyophilized Retatrutide at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, Retatrutide has a reported half-life of ~6 days (once-weekly dosing), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every Retatrutide order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-RTTR-2600315, tested March 12, 2026) shows 99.4% purity by HPLC, mass spectrometry confirmation at 4731.41 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
2381089-83-2
Mol. Weight
4731.41 Da
Formula
C221H342N46O68
Half-Life
~6 days (once-weekly dosing)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg, 10mg, 15mg, 20mg, 30mg, 60mg

Sequence

39-amino acid peptide derived from GIP backbone; contains Aib at positions 2 and 20, alpha-methyl-Leu at position 13, and C20 fatty diacid conjugation at Lys17 via linker

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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