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Análisis de Pureza HPLC
L-Carnitine
CAS: 541-15-1
Estudiado para la activación de vías termogénicas y oxidación de grasas
L-Carnitine is a research peptide in the fat dissolvers / body composition category. L-Carnitine is an amino acid derivative essential for the transport of long-chain fatty acids from the cytoplasm into the mitochondrial matrix via the carnitine shuttle system (CPT-I and CPT-II). MiPeptidos offers L-Carnitine in 4 sizes with 99.7% verified purity and full analytical documentation.
- Burns more fat during exercise
- Boosted workout energy
- Better exercise recovery
- Sharper mental clarity
Studies report improved exercise energy and endurance within the first 1-2 weeks. By weeks 4-8, research suggests a noticeable shift in body composition as fat oxidation increases, especially during moderate-intensity exercise. Over the full 12-week protocol, meta-analyses show significant reductions in body weight and fat mass.
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Análisis de Pureza HPLC
Unlock Fat Burning.
12-week metabolic protocol backed by 6 clinical trials and decades of exercise physiology research
L-Carnitine (beta-hydroxy-gamma-trimethylammonium butyrate) is an amino acid derivative essential for the transport of long-chain fatty acids from the cytoplasm into the mitochondrial matrix via the carnitine shuttle system (CPT-I and CPT-II). Without adequate carnitine, fatty acids cannot enter mitochondria for beta-oxidation — the primary pathway for fat metabolism and energy production.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Eric Volek
Professor of Kinesiology, University of Connecticut
Ph.D. in Kinesiology. One of the foremost researchers on carnitine and fat metabolism. Lead author on landmark L-Carnitine supplementation studies. 300+ publications on metabolic physiology.
We demonstrated that carnitine supplementation increases muscle carnitine content by 21%, enhances fat oxidation during low-intensity exercise, and preserves muscle glycogen — fundamentally improving the body's fuel partitioning.
500-600 mg L-Carnitine administered via subcutaneous injection pre-exercise bypasses oral bioavailability limitations. Co-administer with 80g carbohydrate to stimulate insulin-mediated carnitine uptake into muscle for maximum fat oxidation.
Fuente: Wall et al. (2011) Journal of Physiology; Volek et al. (2002) American J of Physiology
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab podcast. Covers metabolic optimization and fat loss science for a broad audience.
L-Carnitine is the shuttle molecule — it literally carries fatty acids into mitochondria. Without carnitine, you cannot burn fat. Injectable forms deliver dramatically higher tissue levels than oral supplementation.
500-2000 mg L-Carnitine via subcutaneous injection taken with carbohydrate. Time administration 30-60 minutes before exercise for maximal fat oxidation enhancement. Acetyl-L-Carnitine for cognitive benefits.
Fuente: Huberman Lab Podcast: How to Lose Fat with Science-Based Tools (2021)
Dr. Peter Attia
Physician, Founder of Attia Medical PC
MD from Stanford. Host of 'The Drive' podcast. Specialist in longevity medicine and metabolic health. Author of 'Outlive.'
Carnitine is one of those compounds where the physiology is rock solid — you need it for fat oxidation. The debate has been about whether supplementation actually raises tissue levels. Injectable administration resolves that question.
L-Carnitine injections provide superior bioavailability over oral forms. Consider in the context of a comprehensive metabolic protocol including zone 2 training, which depends on mitochondrial fat oxidation capacity.
Fuente: The Peter Attia Drive Podcast: Metabolic Health Deep Dives
Dr. Paola Benatti
Professor of Nutrition, Federal University of Sao Paulo
Ph.D. in Nutritional Sciences. Researcher in L-Carnitine pharmacology and metabolic syndrome. Published systematic reviews on carnitine supplementation and body composition.
Our meta-analysis of 37 randomized controlled trials confirmed that L-Carnitine supplementation significantly reduces body weight, BMI, and fat mass. The effect size increases with higher baseline BMI and longer supplementation duration.
Supplementation for 12+ weeks at doses of 2-3 g/day shows the most consistent body composition benefits. Obese and metabolically compromised individuals show the greatest responses. Combine with structured exercise for additive effects.
Fuente: Talenezhad et al. (2020) Clinical Nutrition ESPEN; Pooyandjoo et al. (2016) Obesity Reviews
Protocolo de Dosificación
3 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Establishes elevated tissue carnitine levels. Inject 30-60 minutes before exercise when possible. The loading phase raises muscle carnitine content to optimize fat oxidation capacity. Rotate injection sites across the abdominal fat pad.
Sustained elevated tissue carnitine supports enhanced fat oxidation during exercise and daily activity. Time injections with training sessions for maximum benefit. Zone 2 cardio and resistance training amplify effects.
Maintains tissue carnitine levels achieved during loading. Ongoing supplementation recommended for individuals over 40 or with high metabolic demands. Continue rotating injection sites.
Injectable L-Carnitine is typically supplied as a ready-to-use sterile solution (200 mg/mL or similar concentration). No reconstitution required for pre-made solutions. For lyophilized forms: dissolve in bacteriostatic water per supplier instructions.
Continuous use is acceptable — L-Carnitine is an endogenous compound with an excellent safety profile. Some protocols cycle 12 weeks on, 4 weeks off to reassess. No receptor desensitization concerns at standard doses.
Pre-made solutions: store at room temperature (15-30°C) away from light. Lyophilized powder: store at -20°C. Once opened/reconstituted, refrigerate and use within 28 days. Do not freeze liquid formulations.
Subcutaneous injection into the abdominal fat pad. Pinch a fold of skin, insert the needle at a 45-degree angle, inject slowly, and release. Rotate injection sites to prevent irritation or lipodystrophy. Can be combined in the same injection with B12 or other lipotropic agents if compatible. Pre-exercise timing optimizes acute fat oxidation enhancement.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Tissue Carnitine Loading
- Injectable L-Carnitine bypasses the 15-20% oral bioavailability limitation
- Plasma carnitine levels rise rapidly — peak within 1-2 hours post-injection
- Muscle carnitine uptake begins — requires insulin-mediated transport (eat carbohydrate post-injection)
- Subjective increase in exercise energy reported in research
- Fat oxidation during low-intensity activity begins to measurably increase
Base de investigación: Wall et al. (2011) Journal of Physiology; Stephens et al. (2006) J Physiology
Enhanced Fat Oxidation Established
- Muscle carnitine content increased by up to 21% with sustained supplementation
- Measurable increase in fat oxidation rate during zone 2 exercise
- Glycogen sparing effect — improved endurance from preferential fat utilization
- Reduced exercise-induced muscle damage markers (creatine kinase, myoglobin)
- Improved post-exercise recovery reported
Base de investigación: Wall et al. (2011) J Physiology; Volek et al. (2002) American J of Physiology
Body Composition Changes
- Measurable reduction in fat mass in conjunction with exercise and caloric management
- Improved body composition metrics — enhanced lean-to-fat ratio
- Sustained improvements in exercise capacity and endurance
- Enhanced recovery between training sessions
- Potential improvements in insulin sensitivity from improved lipid metabolism
Base de investigación: Pooyandjoo et al. (2016) Obesity Reviews; Talenezhad et al. (2020) Clinical Nutrition ESPEN
Sustained Metabolic Optimization
- Meta-analysis shows significant weight and fat mass reduction at 12+ weeks
- Cardiovascular benefits: reduced angina, improved exercise tolerance in cardiac patients
- Maintenance dosing sustains elevated tissue carnitine and enhanced fat oxidation
- Long-term studies report sustained metabolic and performance benefits
Base de investigación: Pooyandjoo meta-analysis; DiNicolantonio et al. (2013) Mayo Clinic Proceedings
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
Carnitine Shuttle System (CPT-I/CPT-II)
L-Carnitine is the essential cofactor for the carnitine palmitoyltransferase system, which transports long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation.
- CPT-I on the outer mitochondrial membrane conjugates carnitine to fatty acyl-CoA
- Carnitine-acylcarnitine translocase moves the complex across the inner membrane
- CPT-II releases the fatty acid for beta-oxidation inside the mitochondrial matrix
- Without adequate carnitine, long-chain fatty acids accumulate in the cytoplasm — they literally cannot be burned
Wall et al. (2011) PMID: 21486762; Biochemistry textbook consensus
Exercise Fuel Partitioning
Elevated muscle carnitine content shifts exercise fuel utilization toward fat oxidation, sparing glycogen reserves and improving endurance capacity.
- 21% increase in muscle carnitine reduced glycogen utilization by 55% during low-intensity exercise
- Higher fat oxidation rates mean more sustained energy from fat stores
- Glycogen sparing delays fatigue onset during prolonged exercise
- Effect is most pronounced during zone 2 (moderate intensity) training — the fat-burning zone
Wall et al. (2011) Journal of Physiology; PMID: 21486762
Androgen Receptor Upregulation
L-Carnitine L-tartrate supplementation increases androgen receptor content in muscle tissue, enhancing the anabolic response to resistance exercise and endogenous testosterone.
- LCLT increased intact androgen receptor content in muscle post-exercise
- More androgen receptors = greater tissue sensitivity to circulating testosterone
- Enhances muscle protein synthesis response to resistance training
- Reduces exercise-induced tissue disruption markers (creatine kinase, myoglobin)
Volek et al. (2002) PMID: 11788366
Investigación Publicada
6 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL — Journal of Physiology (2011)
Hallazgo Clave: 24 weeks of L-Carnitine supplementation increased muscle carnitine content by 21%. Enhanced fat oxidation during low-intensity exercise and reduced muscle glycogen utilization by 55% — the first study to demonstrate exercise fuel partitioning from carnitine loading.
L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress
Volek JS, Kraemer WJ, Rubin MR, Gomez AL, Ratamess NA, Gaynor P — American Journal of Physiology — Endocrinology and Metabolism (2002)
Hallazgo Clave: LCLT supplementation reduced exercise-induced muscle tissue disruption markers, hypoxia markers, and circulating cytosolic proteins. Increased androgen receptor density in muscle — enhancing anabolic signaling capacity.
The effects of L-carnitine supplementation on weight loss: a systematic review and meta-analysis of 37 randomized controlled trials
Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A — Obesity Reviews (2016)
Hallazgo Clave: Meta-analysis of 37 RCTs confirmed L-Carnitine supplementation significantly reduces body weight (WMD: -1.33 kg), BMI (WMD: -0.47), and fat mass (WMD: -2.09 kg). Greater effects with higher baseline BMI and longer supplementation.
L-Carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis
DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH — Mayo Clinic Proceedings (2013)
Hallazgo Clave: Meta-analysis: L-Carnitine reduced all-cause mortality by 27% (p=0.01), ventricular arrhythmias by 65%, and angina by 40% in post-MI patients. Strong cardiovascular protective effects in secondary prevention.
Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease
Lee BJ, Lin JS, Lin YC, Lin PT — Nutrition Journal (2014)
Hallazgo Clave: L-Carnitine supplementation significantly increased SOD and GPx antioxidant enzyme activities while reducing MDA oxidative stress markers. Demonstrates systemic antioxidant benefits beyond fat metabolism.
L-Carnitine and its role in medicine: an updated review of clinical evidence
Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A — Clinical Nutrition ESPEN (2020)
Hallazgo Clave: Updated review confirming L-Carnitine benefits across body composition, cardiovascular health, male fertility (improved sperm motility), exercise performance, and diabetes management. Recommended as an evidence-based metabolic support compound.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar L-Carnitine con estos péptidos para mecanismos complementarios.
Lipo-C provides hepatic lipotropic support (methionine, inositol, choline) that enhances liver fat processing, complementing L-Carnitine's mitochondrial fat transport.
L-Carnitine handles the cellular fat-burning machinery while Lipo-C optimizes the liver's fat-processing capacity. Together they address fat metabolism from transport through hepatic processing.
AOD-9604 stimulates lipolysis (fat cell breakdown) while L-Carnitine transports the released fatty acids into mitochondria for oxidation.
AOD-9604 frees fat from storage; L-Carnitine burns it. Without adequate carnitine, released fatty acids can be re-esterified back into fat. This combination ensures freed fat is actually oxidized.
5-Amino-1MQ inhibits NNMT to increase NAD+ availability and metabolic rate while L-Carnitine optimizes fatty acid oxidation — dual metabolic acceleration.
5-Amino-1MQ raises the metabolic ceiling; L-Carnitine ensures fat is the preferred fuel. Addresses both the rate of metabolism and the substrate availability simultaneously.
MOTS-c is a mitochondrial-derived peptide that enhances metabolic homeostasis and insulin sensitivity, amplifying L-Carnitine's mitochondrial fat oxidation effects.
MOTS-c optimizes mitochondrial function and metabolic signaling while L-Carnitine ensures a steady supply of fatty acid substrate. Together they maximize mitochondrial energy production from fat.
Especificaciones
Cómo Funciona L-Carnitine
L-Carnitine is an amino acid derivative essential for the transport of long-chain fatty acids from the cytoplasm into the mitochondrial matrix via the carnitine shuttle system (CPT-I and CPT-II). Inside mitochondria, fatty acids undergo beta-oxidation for energy production. L-Carnitine also modulates the acyl-CoA/CoA ratio, buffers excess acyl groups, and has antioxidant properties protecting mitochondrial membranes from lipid peroxidation. It enhances fatty acid utilization as an energy substrate, particularly during exercise and caloric restriction.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 |
|---|---|---|
2mg | $30.00 | $255.00 |
400mg | $40.00 | $340.00 |
600mg | $50.00 | $425.00 |
1200mgMejor Valor | $60.00 | $510.00 |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not a substitute for medical treatment of cardiovascular or metabolic disease
L-Carnitine supplementation is adjunctive. Do not replace prescribed medications for heart disease, diabetes, or metabolic syndrome with L-Carnitine. Always consult a physician.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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