MK-677 vs Ipamorelin
Compare MK-677 (Ibutamoren), an orally active non-peptide GH secretagogue, with Ipamorelin, an injectable selective peptide secretagogue. Two different approaches to growth hormone release research.
MK677
Growth Hormone / GH Secretagogues
Ipamorelin
Growth Hormone / GH Secretagogues
Comparación Lado a Lado
Orally active non-peptidic GHSR-1a agonist that mimics ghrelin to increase GH pulse amplitude without altering frequency; maintains elevated GH/IGF-1 levels with once-daily oral dosing
Highly selective injectable peptide GHSR agonist that stimulates pulsatile GH release; does not significantly affect cortisol, ACTH, or prolactin at GH-releasing doses
Ghrelin receptor (GHSR-1a) — non-peptidic oral agonist
Ghrelin/GHS receptor (GHSR) — most selective peptide agonist
~4-6 hours (functional GH elevation lasts ~24 hours)
~2 hours
Typically studied once daily (oral)
Typically studied 2-3x daily (injection)
\u226599% (HPLC verified at 99.1%)
\u226599% (HPLC verified at 99.7%)
Oral GH secretagogue pharmacology, muscle wasting and sarcopenia, bone density improvement, sleep quality and GH pulse enhancement, age-related GH decline
Selective GH secretion without cortisol elevation, synergistic combination with GHRH analogs, bone density and growth studies, body composition and recovery, GH axis selectivity
528.67 Da (non-peptidic small molecule)
711.85 Da (pentapeptide)
$19.95/vial (5mg)
$6.95/vial (2mg)
Orally active non-peptidic GHSR-1a agonist that mimics ghrelin to increase GH pulse amplitude without altering frequency; maintains elevated GH/IGF-1 levels with once-daily oral dosing
Highly selective injectable peptide GHSR agonist that stimulates pulsatile GH release; does not significantly affect cortisol, ACTH, or prolactin at GH-releasing doses
Ghrelin receptor (GHSR-1a) — non-peptidic oral agonist
Ghrelin/GHS receptor (GHSR) — most selective peptide agonist
~4-6 hours (functional GH elevation lasts ~24 hours)
~2 hours
Typically studied once daily (oral)
Typically studied 2-3x daily (injection)
\u226599% (HPLC verified at 99.1%)
\u226599% (HPLC verified at 99.7%)
Oral GH secretagogue pharmacology, muscle wasting and sarcopenia, bone density improvement, sleep quality and GH pulse enhancement, age-related GH decline
Selective GH secretion without cortisol elevation, synergistic combination with GHRH analogs, bone density and growth studies, body composition and recovery, GH axis selectivity
528.67 Da (non-peptidic small molecule)
711.85 Da (pentapeptide)
$19.95/vial (5mg)
$6.95/vial (2mg)
¿Cuál es el Adecuado para tu Investigación?
Choose MK-677 for oral delivery convenience and sustained 24-hour GH/IGF-1 elevation in research. Choose Ipamorelin for the most selective injectable GH release without cortisol or prolactin elevation, ideal for protocols requiring clean pulsatile GH patterns.