MK677 - Front - MiPeptidos
Growth Hormone / GH Secretagogues

MK677

CAS: 159634-47-6

MK677 is a research peptide in the growth hormone / gh secretagogues category. MK-677 is an orally active, non-peptidic ghrelin receptor (GHSR-1a) agonist that mimics the GH-releasing activity of ghrelin. MiPeptidos offers MK677 in 1 sizes with 99.1% verified purity and full analytical documentation.

Starting at
$19.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
Third-Party Tested
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How MK677 Works

MK-677 is an orally active, non-peptidic ghrelin receptor (GHSR-1a) agonist that mimics the GH-releasing activity of ghrelin. It stimulates pituitary GH release by binding to GHSR-1a, increasing GH pulse amplitude without altering pulse frequency. It also increases IGF-1 levels, promotes nitrogen retention, and stimulates appetite. Unlike peptide GH secretagogues, it is orally bioavailable and has a long duration of action, maintaining elevated GH and IGF-1 levels with once-daily dosing.

Research Applications

1
Oral GH secretagogue pharmacology
2
Muscle wasting and sarcopenia
3
Bone density improvement
4
Sleep quality and GH pulse enhancement
5
Age-related GH decline reversal
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
5mg
$19.95$145.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.1%purity
mAURetention Time (min)0250500750100005101520253099.1%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
MK677
PASSES ALL SPECIFICATIONS
Batch NumberHR-MK67-2600315
Date of AnalysisJanuary 21, 2026
Purity (HPLC)99.1%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)528.67 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Reconstitution Calculator

Add this much bacteriostatic water:
5.0 mL
5 mg MK677 + 5.0 mL BAC water = 1 mg/mL

Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved — never shake. Store reconstituted solution at 2-8°C and use within 30 days.

Download Product Brochure

Get our detailed MK677 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Antonio Silva·Lisbon, Portugal

MK-677 (Ibutamoren) from MiPeptidos is the non-peptide ghrelin receptor agonist we use as a positive control in our oral GH secretagogue research. The small molecule shows expected sustained GH elevation in our assays. P...

Feb 6, 2026
View All Reviews →

Frequently Asked Questions

MK677 (CAS: 159634-47-6) is a research compound, with a molecular weight of 528.67 Da in the Growth Hormone / GH Secretagogues category. MK-677 is an orally active, non-peptidic ghrelin receptor (GHSR-1a) agonist that mimics the GH-releasing activity of ghrelin. It stimulates pituitary GH release by binding to GHSR-1a, increasing GH pulse amplitude without altering pulse frequency. Researchers commonly investigate MK677 for Oral GH secretagogue pharmacology, Muscle wasting and sarcopenia, Bone density improvement. Every vial from MiPeptidos includes batch-specific analytical documentation.
To reconstitute your MK677 5mg vial, let it reach room temperature for about 15-20 minutes out of the freezer. Slowly inject 1-2mL of bacteriostatic water along the inside wall of the vial — never aim directly at the peptide cake. Gently swirl until the powder fully dissolves; never shake, as this can denature the peptide. Store reconstituted MK677 at 2-8°C and use within 30 days. MiPeptidos includes bacteriostatic water for purchase alongside all peptides.
MK-677 (Ibutamoren) is NOT a peptide — it is a small molecule (529 Da) ghrelin receptor agonist with oral bioavailability, while Ipamorelin is a pentapeptide requiring injection. MK-677 has a 24-hour half-life producing sustained GH elevation around the clock, while Ipamorelin produces acute GH pulses lasting ~2 hours. MK-677 does increase appetite and IGF-1 baseline, and it does not require reconstitution. MiPeptidos carries both for researchers comparing injectable peptide vs oral non-peptide GH secretagogue approaches.
Store lyophilized MK677 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, MK677 has a reported half-life of ~4-6 hours (functional GH elevation lasts ~24 hours), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every MK677 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-MK67-2600315, tested January 21, 2026) shows 99.1% purity by HPLC, mass spectrometry confirmation at 528.67 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
159634-47-6
Mol. Weight
528.67 Da
Formula
C27H36N4O5S
Half-Life
~4-6 hours (functional GH elevation lasts ~24 hours)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
5mg

Sequence

N/A (not a peptide; non-peptidic small molecule)

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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