MK-677 vs Ipamorelin
Compare MK-677 (Ibutamoren), an orally active non-peptide GH secretagogue, with Ipamorelin, an injectable selective peptide secretagogue. Two different approaches to growth hormone release research.
MK677
Growth Hormone / GH Secretagogues
Ipamorelin
Growth Hormone / GH Secretagogues
Side-by-Side Comparison
Orally active non-peptidic GHSR-1a agonist that mimics ghrelin to increase GH pulse amplitude without altering frequency; maintains elevated GH/IGF-1 levels with once-daily oral dosing
Highly selective injectable peptide GHSR agonist that stimulates pulsatile GH release; does not significantly affect cortisol, ACTH, or prolactin at GH-releasing doses
Ghrelin receptor (GHSR-1a) — non-peptidic oral agonist
Ghrelin/GHS receptor (GHSR) — most selective peptide agonist
~4-6 hours (functional GH elevation lasts ~24 hours)
~2 hours
Typically studied once daily (oral)
Typically studied 2-3x daily (injection)
\u226599% (HPLC verified at 99.1%)
\u226599% (HPLC verified at 99.7%)
Oral GH secretagogue pharmacology, muscle wasting and sarcopenia, bone density improvement, sleep quality and GH pulse enhancement, age-related GH decline
Selective GH secretion without cortisol elevation, synergistic combination with GHRH analogs, bone density and growth studies, body composition and recovery, GH axis selectivity
528.67 Da (non-peptidic small molecule)
711.85 Da (pentapeptide)
$19.95/vial (5mg)
$6.95/vial (2mg)
Orally active non-peptidic GHSR-1a agonist that mimics ghrelin to increase GH pulse amplitude without altering frequency; maintains elevated GH/IGF-1 levels with once-daily oral dosing
Highly selective injectable peptide GHSR agonist that stimulates pulsatile GH release; does not significantly affect cortisol, ACTH, or prolactin at GH-releasing doses
Ghrelin receptor (GHSR-1a) — non-peptidic oral agonist
Ghrelin/GHS receptor (GHSR) — most selective peptide agonist
~4-6 hours (functional GH elevation lasts ~24 hours)
~2 hours
Typically studied once daily (oral)
Typically studied 2-3x daily (injection)
\u226599% (HPLC verified at 99.1%)
\u226599% (HPLC verified at 99.7%)
Oral GH secretagogue pharmacology, muscle wasting and sarcopenia, bone density improvement, sleep quality and GH pulse enhancement, age-related GH decline
Selective GH secretion without cortisol elevation, synergistic combination with GHRH analogs, bone density and growth studies, body composition and recovery, GH axis selectivity
528.67 Da (non-peptidic small molecule)
711.85 Da (pentapeptide)
$19.95/vial (5mg)
$6.95/vial (2mg)
Detailed Breakdown
Mechanism
Orally active non-peptidic GHSR-1a agonist that mimics ghrelin to increase GH pulse amplitude without altering frequency; maintains elevated GH/IGF-1 levels with once-daily oral dosing
Highly selective injectable peptide GHSR agonist that stimulates pulsatile GH release; does not significantly affect cortisol, ACTH, or prolactin at GH-releasing doses
Receptor Targets
Ghrelin receptor (GHSR-1a) — non-peptidic oral agonist
Ghrelin/GHS receptor (GHSR) — most selective peptide agonist
Half-Life
~4-6 hours (functional GH elevation lasts ~24 hours)
~2 hours
Dosing Frequency
Typically studied once daily (oral)
Typically studied 2-3x daily (injection)
Purity
\u226599% (HPLC verified at 99.1%)
\u226599% (HPLC verified at 99.7%)
Research Applications
Oral GH secretagogue pharmacology, muscle wasting and sarcopenia, bone density improvement, sleep quality and GH pulse enhancement, age-related GH decline
Selective GH secretion without cortisol elevation, synergistic combination with GHRH analogs, bone density and growth studies, body composition and recovery, GH axis selectivity
Molecular Weight
528.67 Da (non-peptidic small molecule)
711.85 Da (pentapeptide)
Starting Price
$19.95/vial (5mg)
$6.95/vial (2mg)
Which Is Right for Your Research?
Choose MK-677 for oral delivery convenience and sustained 24-hour GH/IGF-1 elevation in research. Choose Ipamorelin for the most selective injectable GH release without cortisol or prolactin elevation, ideal for protocols requiring clean pulsatile GH patterns.