Epithalon vs NAD+
Compare Epithalon and NAD+, two leading anti-aging research compounds that target different hallmarks of aging. One extends telomeres, the other fuels cellular energy and DNA repair.
Epithalon
Anti-Aging / Longevity
NAD+
Anti-Aging / Longevity
Side-by-Side Comparison
Activates telomerase (hTERT) to extend telomere length, stimulates pineal melatonin production, modulates antioxidant enzyme expression, shown to extend lifespan in animal models
Essential coenzyme and electron carrier in metabolic redox reactions; substrate for sirtuins (SIRT1-7), PARPs, and CD38; activates DNA repair, mitochondrial biogenesis, and stress resilience pathways
Telomerase (hTERT) enzyme, pineal gland melatonin synthesis pathways
Sirtuins (SIRT1-7), PARPs, CD38 (NAD+-consuming enzymes)
Short in plasma; biological effects (telomerase activation) persist for weeks
~30-45 minutes in plasma (rapidly metabolized)
Typically studied in 10-20 day cycles
Typically studied daily or several times weekly
\u226599% (HPLC verified at 99.5%)
\u226599% (HPLC verified at 99.3%)
Telomerase activation and telomere elongation, anti-aging and lifespan extension, circadian rhythm restoration, cancer prevention through telomere stabilization, age-related gene expression
Age-related NAD+ decline, sirtuin biology and activation, DNA repair and genomic stability, mitochondrial function and biogenesis, neurodegeneration and neuroprotection
390.35 Da (tetrapeptide)
663.43 Da (dinucleotide coenzyme)
$14.95/vial (10mg)
$26.95/vial (100mg)
Activates telomerase (hTERT) to extend telomere length, stimulates pineal melatonin production, modulates antioxidant enzyme expression, shown to extend lifespan in animal models
Essential coenzyme and electron carrier in metabolic redox reactions; substrate for sirtuins (SIRT1-7), PARPs, and CD38; activates DNA repair, mitochondrial biogenesis, and stress resilience pathways
Telomerase (hTERT) enzyme, pineal gland melatonin synthesis pathways
Sirtuins (SIRT1-7), PARPs, CD38 (NAD+-consuming enzymes)
Short in plasma; biological effects (telomerase activation) persist for weeks
~30-45 minutes in plasma (rapidly metabolized)
Typically studied in 10-20 day cycles
Typically studied daily or several times weekly
\u226599% (HPLC verified at 99.5%)
\u226599% (HPLC verified at 99.3%)
Telomerase activation and telomere elongation, anti-aging and lifespan extension, circadian rhythm restoration, cancer prevention through telomere stabilization, age-related gene expression
Age-related NAD+ decline, sirtuin biology and activation, DNA repair and genomic stability, mitochondrial function and biogenesis, neurodegeneration and neuroprotection
390.35 Da (tetrapeptide)
663.43 Da (dinucleotide coenzyme)
$14.95/vial (10mg)
$26.95/vial (100mg)
Detailed Breakdown
Mechanism
Activates telomerase (hTERT) to extend telomere length, stimulates pineal melatonin production, modulates antioxidant enzyme expression, shown to extend lifespan in animal models
Essential coenzyme and electron carrier in metabolic redox reactions; substrate for sirtuins (SIRT1-7), PARPs, and CD38; activates DNA repair, mitochondrial biogenesis, and stress resilience pathways
Receptor Targets
Telomerase (hTERT) enzyme, pineal gland melatonin synthesis pathways
Sirtuins (SIRT1-7), PARPs, CD38 (NAD+-consuming enzymes)
Half-Life
Short in plasma; biological effects (telomerase activation) persist for weeks
~30-45 minutes in plasma (rapidly metabolized)
Dosing Frequency
Typically studied in 10-20 day cycles
Typically studied daily or several times weekly
Purity
\u226599% (HPLC verified at 99.5%)
\u226599% (HPLC verified at 99.3%)
Research Applications
Telomerase activation and telomere elongation, anti-aging and lifespan extension, circadian rhythm restoration, cancer prevention through telomere stabilization, age-related gene expression
Age-related NAD+ decline, sirtuin biology and activation, DNA repair and genomic stability, mitochondrial function and biogenesis, neurodegeneration and neuroprotection
Molecular Weight
390.35 Da (tetrapeptide)
663.43 Da (dinucleotide coenzyme)
Starting Price
$14.95/vial (10mg)
$26.95/vial (100mg)
Which Is Right for Your Research?
Choose Epithalon for telomerase activation and telomere elongation research targeting replicative senescence. Choose NAD+ for sirtuin-dependent pathways, mitochondrial biogenesis, and cellular energy metabolism research. They target complementary aging mechanisms.