IGF-1 LR3 - Front - MiPeptidos
Growth Hormone / GH Secretagogues

IGF-1 LR3

CAS: 946870-92-4

IGF-1 LR3 is a research peptide in the growth hormone / gh secretagogues category. IGF-1 LR3 is a synthetic 83-amino acid analog of IGF-1 (which has 70 amino acids) with an arginine at position 3 and a 13-amino acid extension at the N-terminus. MiPeptidos offers IGF-1 LR3 in 2 sizes with 99.5% verified purity and full analytical documentation.

Starting at
$8.95/vial
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≥99% Purity
COA Included
Third-Party Tested
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CoA Included
HPLC Verified
GMP Compliant
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How IGF-1 LR3 Works

IGF-1 LR3 is a synthetic 83-amino acid analog of IGF-1 (which has 70 amino acids) with an arginine at position 3 and a 13-amino acid extension at the N-terminus. These modifications reduce binding to IGF binding proteins (IGFBPs) by over 100-fold, resulting in dramatically higher bioavailability and potency compared to native IGF-1. It activates the IGF-1 receptor to stimulate the PI3K/Akt and MAPK/ERK pathways, promoting cell proliferation, differentiation, survival, and protein synthesis in muscle and other tissues.

Research Applications

1
Muscle growth and hypertrophy beyond GH/IGF-1 axis
2
IGFBP-independent IGF-1 signaling
3
Cell proliferation and anti-apoptosis
4
Glucose uptake and metabolic research
5
Tissue engineering and regenerative medicine
View Published Research on PubMed →

Pricing

SizePer Vial10-Pack
100mcg
$8.95$64.95
1mgBest Value
$54.95$400.95

Prices shown per vial from 10-pack. Volume discounts available for 50+ vials — contact us.

HPLC Purity Analysis

High-Performance Liquid Chromatography
99.5%purity
mAURetention Time (min)0250500750100005101520253099.5%
Method: RP-HPLC C18 ColumnDetection: UV 220nmMobile Phase: Acetonitrile/Water + 0.1% TFA

Certificate of Analysis

MiPeptidos
IGF-1 LR3
PASSES ALL SPECIFICATIONS
Batch NumberHR-GF1L-2600115
Date of AnalysisMarch 5, 2026
Purity (HPLC)99.5%
AppearanceWhite to off-white lyophilized powder
SolubilityFreely soluble in sterile water and bacteriostatic water
Molecular Weight (MS)9117.50 Da — Confirmed
Endotoxin (LAL)<0.1 EU/mg
Sterility (USP <71>)Passes USP <71>

This COA is a representative sample. A batch-specific Certificate of Analysis with full HPLC chromatograms and mass spectrometry data is included with every MiPeptidos order.

Download Product Brochure

Get our detailed IGF-1 LR3 product brochure with specifications, research applications, HPLC analysis data, and reconstitution guide. Available in English and Spanish.

Customer Reviews

5.0/5from 1 review
Verified
Dr. Wei Chen·Beijing, China

IGF-1 LR3 is our primary growth factor for cell culture supplementation research. The Long R3 variant from MiPeptidos has the expected reduced IGF-binding protein affinity and enhanced receptor activation. The 83-amino-a...

Jan 28, 2026
View All Reviews →

Frequently Asked Questions

IGF-1 LR3 (CAS: 946870-92-4) is a research compound, with a molecular weight of 9117.50 Da in the Growth Hormone / GH Secretagogues category. IGF-1 LR3 is a synthetic 83-amino acid analog of IGF-1 (which has 70 amino acids) with an arginine at position 3 and a 13-amino acid extension at the N-terminus. These modifications reduce binding to IGF binding proteins (IGFBPs) by over 100-fold, resulting in dramatically higher bioavailability and potency compared to native IGF-1. Researchers commonly investigate IGF-1 LR3 for Muscle growth and hypertrophy beyond GH/IGF-1 axis, IGFBP-independent IGF-1 signaling, Cell proliferation and anti-apoptosis. Every vial from MiPeptidos includes batch-specific analytical documentation.
IGF-1 LR3 is available in 2 sizes (100mcg, 1mg), so reconstitution volume depends on which vial you have. For the 100mcg size, add 6-8mL of bacteriostatic water; for the 1mg size, use 1mL. Always let the vial warm to room temperature first, inject the water slowly along the vial wall, and swirl gently — never shake. Store reconstituted IGF-1 LR3 at 2-8°C and use within 30 days. MiPeptidos carries bacteriostatic water in 3mL and 10mL vials.
IGF-1 LR3 is an 83-amino acid modified version of IGF-1 with an arginine-for-glutamic acid substitution at position 3 plus a 13-amino acid N-terminal extension. These modifications reduce IGF binding protein (IGFBP) affinity by >100-fold, dramatically increasing its bioavailability and half-life (~20-30 hours vs ~15 minutes for native IGF-1). At 9118 Da, it is the most potent form of IGF-1 available for research. MiPeptidos stocks it in 0.1mg and 1mg sizes.
Store lyophilized IGF-1 LR3 at -20°C for maximum long-term stability — properly stored, it remains potent for 24+ months. Once reconstituted with bacteriostatic water, keep it refrigerated at 2-8°C and use within 30 days. In research applications, IGF-1 LR3 has a reported half-life of ~20-30 hours (due to minimal IGFBP binding), which informs dosing frequency and protocol design. Avoid repeated freeze-thaw cycles and protect from direct light. MiPeptidos ships every order with cold-chain packaging to maintain integrity during transit.
Every IGF-1 LR3 order from MiPeptidos includes a batch-specific Certificate of Analysis. Our current batch (HR-GF1L-2600115, tested March 5, 2026) shows 99.5% purity by HPLC, mass spectrometry confirmation at 9117.50 Da, endotoxin levels below 0.1 EU/mg, and passing sterility per USP <71>. This level of documentation ensures you can verify compound identity and purity before beginning your research. MiPeptidos also offers bulk pricing on orders of 50+ vials — contact info@mipeptidos.com.

Specifications

Purity
≥99%
Form
Lyophilized Powder
CAS Number
946870-92-4
Mol. Weight
9117.50 Da
Formula
C400H625N111O115S9
Half-Life
~20-30 hours (due to minimal IGFBP binding)
Storage
Store at -20°C. Reconstituted: 2–8°C for up to 30 days.
Sizes
100mcg, 1mg

Sequence

83-amino acid protein; modified IGF-1 with Arg substitution at position 3 and a 13-amino acid N-terminal extension peptide

Research Use Only. This product is intended for laboratory research purposes only. Not for human consumption. Handle with appropriate safety precautions.

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