Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
IGF-1 LR3
CAS: 946870-92-4
Señalización directa de IGF-1 estudiada para vías de hipertrofia muscular
IGF-1 LR3 is a research peptide in the growth hormone / gh secretagogues category. IGF-1 LR3 is a synthetic 83-amino acid analog of IGF-1 (which has 70 amino acids) with an arginine at position 3 and a 13-amino acid extension at the N-terminus. MiPeptidos offers IGF-1 LR3 in 2 sizes with 99.5% verified purity and full analytical documentation.
- Potent muscle growth support
- Enhanced training pumps
- Faster recovery between sets
- Improved nutrient partitioning
Studies report enhanced muscle pumps and improved recovery within the first few days. By weeks 2-3, research suggests measurable changes in body composition, increased muscle fullness, and strength improvements. This is a potent short-cycle peptide — typical protocols run just 3-4 weeks.
$40.09/vial · Everything you need to start
Sin spam. Cancela en cualquier momento.
Análisis de Pureza HPLC
Direct Anabolic Signaling.
4-week IGF-1 receptor activation protocol — bypassing the GH pathway for direct growth signaling
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid analog of IGF-1 with two key modifications: an arginine substitution at position 3 and a 13-amino acid extension at the N-terminus. These modifications reduce binding to IGF-binding proteins (IGFBPs) by over 95%, dramatically increasing the amount of free, biologically active IGF-1 in circulation.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. William Seeds
Founder, SSRP Institute
40+ years in cellular and molecular medicine. Author of 'Peptide Protocols: Volume 1'.
IGF-1 LR3 is the most direct anabolic peptide available. It bypasses GH entirely and activates the IGF-1 receptor directly. The LR3 modification gives it dramatically more bioactivity than native IGF-1.
20–40 mcg subcutaneous daily. Short cycles only (3–4 weeks) due to potent growth-promoting effects. Not for extended use. Monitor blood glucose carefully.
Fuente: Peptide Protocols: Volume 1 (ISBN: 978-0578624358)
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab.
IGF-1 LR3 is essentially giving your cells the growth signal directly, bypassing the pituitary entirely. It's the most potent direct-acting growth factor peptide available. But potency means risk — the proliferative potential is very real.
Consider IGF-1 LR3 only for specific research applications where direct IGF-1R activation is needed. It is more potent and less forgiving than GH secretagogues. Blood glucose monitoring is essential.
Fuente: Huberman Lab Podcast: Growth Factors & Muscle Biology
Dr. Derek LeRoith
Director, Diabetes & Endocrinology, Icahn School of Medicine at Mount Sinai
World authority on the IGF-1 signaling axis. Published over 500 papers on insulin-like growth factors and their receptors.
The IGF-1 receptor activates PI3K/Akt/mTOR and Ras/MAPK signaling cascades — the two most powerful growth and survival pathways in the cell. LR3 modification provides enhanced bioavailability by evading IGFBP sequestration.
Research context only. The enhanced free-IGF-1 bioavailability means lower absolute doses are needed. The proliferative potential is significant and must be carefully considered.
Fuente: LeRoith et al. (2001) Endocr Rev; LeRoith & Yakar (2007) Nat Clin Pract Endocrinol Metab
Dr. Michael Kjaer
Professor of Sports Medicine, University of Copenhagen
Published extensively on growth factors in musculoskeletal tissue repair. Expert in IGF-1 signaling in tendon, muscle, and connective tissue.
IGF-1 is the critical downstream mediator of most growth hormone effects on muscle. Direct IGF-1R activation drives both hypertrophy (via mTOR) and hyperplasia (via satellite cell proliferation).
Research application in musculoskeletal repair contexts. IGF-1 LR3 provides a direct tool for studying IGF-1R-mediated repair independently of the GH axis.
Fuente: Kjaer et al. (2006) Scand J Med Sci Sports
Protocolo de Dosificación
2 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Start at 20 mcg and assess glucose response. Monitor blood sugar closely — IGF-1 has insulin-like hypoglycemic effects. Rotate injection sites.
For targeted muscle growth. Inject subcutaneously bilaterally for symmetry. Provides both systemic and local IGF-1R activation.
Add 1 mL bacteriostatic water to 1 mg vial = 1,000 mcg/mL. 20 mcg = 2 units on insulin syringe; 40 mcg = 4 units. Use bacteriostatic water only (0.9% benzyl alcohol).
CRITICAL: Short cycles only — 4 weeks maximum, 4–6 weeks off. IGF-1 LR3 is potent and proliferative. Never run extended cycles. Some practitioners use 3 weeks on, 1 week off.
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 21 days. IGF-1 LR3 is less stable than many peptides — handle carefully, never shake.
Subcutaneous injection. Administer with a meal or have glucose available — IGF-1 LR3 can cause hypoglycemia. Avoid fasted administration. Rotate injection sites.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
IGF-1 Receptor Activation
- Immediate PI3K/Akt/mTOR pathway activation upon injection
- Possible mild hypoglycemia if administered fasted (insulin-like effects)
- Enhanced muscle pumps during training (IGF-1-mediated nutrient partitioning)
- Improved recovery between sessions within days
- Potential water retention from IGF-1-mediated sodium/fluid handling
Base de investigación: LeRoith et al. (2001) Endocr Rev; IGF-1R signaling literature
Anabolic Peak & Composition Changes
- Significant muscle fullness and hardness improvement
- Accelerated recovery allowing higher training volume
- Measurable lean mass gains (1–2 kg typical in responders)
- Improved nutrient partitioning — calories directed toward muscle
- Enhanced satellite cell proliferation and differentiation
Base de investigación: IGF-1R/PI3K/Akt/mTOR signaling; satellite cell biology
Protocol Completion
- Peak body composition and performance effects
- Cycle off to prevent receptor desensitization and limit proliferative exposure
- Effects persist briefly after discontinuation (20–30 hour half-life clearance)
- Lean mass gains maintained with continued training and nutrition
Base de investigación: IGF-1 LR3 pharmacokinetic data; practical protocol outcomes
Washout & Consolidation
- IGF-1R sensitivity normalizes during washout
- Can switch to GH secretagogues for indirect IGF-1 support
- Lean mass gains consolidate with proper training
- Monitor blood glucose normalization
Base de investigación: IGF-1R receptor physiology; growth factor cycling literature
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
PI3K/Akt/mTOR Activation
IGF-1 LR3 binds IGF-1R, activating the PI3K/Akt/mTOR cascade — the primary driver of ribosomal biogenesis, protein synthesis, and cell survival in skeletal muscle.
- mTOR activation drives ribosomal biogenesis for increased translational capacity
- Akt inhibits FoxO transcription factors — reducing protein degradation
- Net effect: dramatically increased protein synthesis, decreased protein breakdown
Schiaffino & Mammucari (2011) PMID: 22108601
Enhanced Bioavailability (IGFBP Evasion)
The LR3 modification (Arg3 substitution + N-terminal extension) reduces binding to IGFBPs by >95%, keeping the peptide in free, bioactive form rather than sequestered.
- >95% reduction in IGFBP-1, -2, -3, -4, -5, -6 binding
- 2–3x greater biological potency than native IGF-1
- Extended half-life: 20–30 hours (vs ~15 min for native IGF-1)
Francis et al. (1992) PMID: 1383564
Satellite Cell Proliferation & Differentiation
IGF-1 LR3 drives both proliferation and terminal differentiation of satellite cells through PI3K-dependent signaling, converting activated stem cells into functional myofibers.
- Promotes satellite cell proliferation (cell division)
- Drives terminal differentiation (myoblast → myocyte → myofiber fusion)
- Essential for converting MGF-activated stem cells into mature muscle
Musaro et al. (1999) PMID: 10454577; Barton (2006) PMID: 16908196
Investigación Publicada
5 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
The insulin-like growth factor system: its role in physiology and pathophysiology
LeRoith D, Werner H, Beitner-Johnson D, Roberts CT Jr — Endocrine Reviews (2001)
Hallazgo Clave: Comprehensive review of the IGF-1 signaling axis. IGF-1R activates PI3K/Akt/mTOR (cell survival, growth) and Ras/MAPK (proliferation) — the two most potent growth cascades.
Long R3 IGF-1 has reduced binding to IGF binding proteins
Francis GL, Ross M, Ballard FJ, et al. — Journal of Endocrinology (1992)
Hallazgo Clave: LR3 modification reduced IGFBP binding by >95% while maintaining full IGF-1R binding affinity. Resulted in 2–3 fold greater biological potency than native IGF-1.
IGF-1 signaling pathways in skeletal muscle hypertrophy
Schiaffino S, Mammucari C — Nature Reviews Molecular Cell Biology (2011)
Hallazgo Clave: IGF-1/PI3K/Akt/mTOR pathway is the primary driver of skeletal muscle hypertrophy. mTOR activation increases ribosomal biogenesis and protein synthesis. Akt inhibits protein degradation via FoxO.
IGF-I and mechanisms of skeletal muscle hypertrophy
Barton ER — Growth Hormone & IGF Research (2006)
Hallazgo Clave: IGF-1 drives muscle hypertrophy through both increased protein synthesis (mTOR) and satellite cell activation/proliferation. Dual mechanism makes it uniquely potent for muscle growth.
Insulin-like growth factor I promotes maturation of satellite cells
Musaro A, McCullagh KJ, Naya FJ, et al. — Molecular Cell Biology (1999)
Hallazgo Clave: IGF-1 promotes both proliferation and differentiation of muscle satellite cells through PI3K-dependent pathways. Essential for satellite cell maturation into functional myofibers.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar IGF-1 LR3 con estos péptidos para mecanismos complementarios.
MGF activates satellite cells; IGF-1 LR3 drives their proliferation and differentiation. Sequential activation → proliferation cascade.
Complete muscle regeneration cascade — satellite cell activation plus maturation signaling for maximum hypertrophy potential.
CJC/Ipa elevates endogenous GH while IGF-1 LR3 provides direct exogenous IGF-1R activation — upstream and downstream coverage simultaneously.
Maximum GH/IGF-1 axis activation from both endogenous (CJC/Ipa) and exogenous (IGF-1 LR3) sources simultaneously.
HGH provides GH receptor activation and hepatic IGF-1 production while IGF-1 LR3 provides direct IGF-1 receptor activation — the full axis covered.
Full GH/IGF-1 axis engagement — direct GH effects (lipolysis, protein synthesis) plus enhanced IGF-1R activation.
BPC-157 upregulates GH receptors and drives tissue repair while IGF-1 LR3 provides the direct growth signal for anabolic processes.
Tissue repair (BPC-157) amplified by direct anabolic signaling (IGF-1 LR3) — recovery plus growth simultaneously.
Especificaciones
Cómo Funciona IGF-1 LR3
IGF-1 LR3 is a synthetic 83-amino acid analog of IGF-1 (which has 70 amino acids) with an arginine at position 3 and a 13-amino acid extension at the N-terminus. These modifications reduce binding to IGF binding proteins (IGFBPs) by over 100-fold, resulting in dramatically higher bioavailability and potency compared to native IGF-1. It activates the IGF-1 receptor to stimulate the PI3K/Akt and MAPK/ERK pathways, promoting cell proliferation, differentiation, survival, and protein synthesis in muscle and other tissues.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
100mcgOferta | $26.95$30.00 | $229.07 | 10% descuento |
1mgMejor ValorOferta | $55.95$160.00 | $475.57 | 65% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
IGF-1 LR3 is a research peptide only. It is not an approved pharmaceutical. All information is for research and educational purposes.
Significant cancer risk from enhanced IGF-1R activation
IGF-1 LR3 is 2–3x more potent than native IGF-1 with 20–30 hour half-life. Sustained IGF-1R activation promotes cell proliferation. Absolute contraindication with any cancer history.
Hypoglycemia risk — must not administer fasted
IGF-1 has insulin-like glucose-lowering effects. IGF-1 LR3's enhanced potency increases hypoglycemia risk. Always administer with or shortly after a meal. Keep glucose available.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
Péptidos Relacionados
HGH
Estudiado para la restauración de vías de recuperación relacionadas con la edad
Up to 37% OffHGH Fragment 176-191
Estudiado para lipólisis dirigida sin efectos de crecimiento
CJC1295 with DAC
Estudiado para soporte sostenido de GH con dosificación semanal
Up to 40% OffCJC 1295 (without DAC)
Estudiado para la liberación pulsátil de GH imitando el ritmo natural