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Análisis de Pureza HPLC
Hexarelin Acetate
CAS: 140703-51-1
Estudiado para la liberación potente de GH con propiedades cardioprotectoras
Hexarelin Acetate is a research peptide in the growth hormone / gh secretagogues category. Hexarelin is a synthetic hexapeptide GH secretagogue that acts on the ghrelin receptor (GHSR-1a) to stimulate pituitary GH release. MiPeptidos offers Hexarelin Acetate in 2 sizes with 99.5% verified purity and full analytical documentation.
- Biggest GH spike per dose
- Heart-protective via CD36
- Dramatic sleep improvement
- Rapid body composition shifts
Studies report a pronounced GH pulse with tingling and warmth from the very first dose, along with dramatically deeper sleep. By weeks 3-4, research suggests IGF-1 rises 40-80% above baseline and body composition visibly changes. Best used in short 4-8 week bursts since the body gradually adapts.
$18.20/vial · Everything you need to start
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Análisis de Pureza HPLC
Peak GH + Cardioprotection.
8-week protocol with the strongest GH secretagogue plus unique heart-protective properties
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue and the most potent GHRP ever developed. It produces the highest GH pulse amplitude of any secretagogue compound, approximately 2–3 times greater peak GH than GHRP-6 or GHRP-2 at equivalent doses.
Resultados Publicados
Revisado por ParesResultados cuantificables de investigación clínica publicada.
Lo que Dicen los Expertos
4 MédicosProfesionales e investigadores líderes que han estudiado y prescrito este péptido.
Dr. Romano Deghenghi
Inventor of Hexarelin, Europeptides
Medicinal chemist who designed and patented hexarelin. Pioneered the development of GH secretagogue hexapeptides for clinical application.
Hexarelin is the most potent growth hormone releasing peptide known. Its cardioprotective effects through the CD36 receptor represent a entirely separate pharmacological action — not mediated through GH release.
Research dosing: 1–2 mcg/kg subcutaneous or IV. GH response peaks at 20 minutes. Cardioprotective effects demonstrated at lower doses. Cycle to avoid desensitization.
Fuente: Deghenghi et al. (1994) Life Sciences; Multiple hexarelin patents
Dr. William Seeds
Founder, SSRP Institute
40+ years in cellular and molecular medicine. Author of 'Peptide Protocols: Volume 1'.
Hexarelin gives you the biggest GH spike of any secretagogue — but it desensitizes. I use it for short, aggressive bursts when maximum GH output is needed, then switch to ipamorelin for maintenance.
100–200 mcg subcutaneous 1–2 times daily. Limit to 4–8 weeks maximum due to desensitization. Do not exceed 16 weeks continuous. 6–8 week washout between cycles.
Fuente: Peptide Protocols: Volume 1 (ISBN: 978-0578624358)
Dr. Ezio Ghigo
Professor of Endocrinology, University of Turin
Leading clinical researcher on hexarelin and GH secretagogues. Published extensively on hexarelin's GH-releasing and cardioprotective properties.
Hexarelin produces the most powerful GH response of any synthetic secretagogue. The cardiac effects through CD36 are independent and additive — making hexarelin pharmacologically unique.
Clinical research: 1.0 mcg/kg IV or SC. GH response predictable and reproducible. Cardiac protective doses may be lower than GH-releasing doses.
Fuente: Ghigo et al. (1999) Endocrine Reviews; Multiple hexarelin clinical studies
Dr. Andrew Huberman
Professor of Neurobiology, Stanford University
Ph.D. in Neuroscience. Host of Huberman Lab.
Hexarelin is interesting because it's the strongest GH releaser but it also has these cardiac effects through a completely separate receptor — CD36. The desensitization issue is real though, so timing matters.
Short bursts only. 4–8 weeks maximum before switching to a non-desensitizing alternative like ipamorelin. The cardiac benefits may persist at lower doses even after GH desensitization.
Fuente: Huberman Lab Podcast: Peptide Therapeutics Discussion (2024)
Protocolo de Dosificación
2 FasesRégimen de dosificación paso a paso compilado de profesionales líderes e investigación clínica.
Hexarelin produces maximum GH release from the first dose. No loading period needed. Combine with CJC-1295 for synergistic effect. Must be fasted.
Reduce to single daily dose. GH response may begin to attenuate after week 4–6 due to desensitization. Bedtime dose maximizes recovery benefit.
Add 2.5 mL bacteriostatic water to 5 mg vial = 2,000 mcg/mL. 100 mcg = 5 units on insulin syringe.
CRITICAL: Hexarelin develops tachyphylaxis within 14–16 weeks. Limit cycles to 4–8 weeks. 6–8 week washout between cycles. Switch to ipamorelin during off-cycles if GH support needed.
Lyophilized: -20°C for 24+ months. Reconstituted: 2–8°C, use within 28 days.
Subcutaneous injection, fasted. Produces the strongest GH pulse of any secretagogue — expect pronounced tingling, flushing, and transient warmth.
Cronología de Recuperación
Basado en observaciones de investigación publicada. Los resultados individuales varían. Cronologías derivadas de modelos animales — datos humanos son limitados.
Maximum GH Output
- Strongest GH pulse of any secretagogue — 2–3x GHRP-6/GHRP-2
- Pronounced tingling, flushing, and warmth (GH-mediated vascular effects)
- Dramatic sleep quality improvement
- Moderate appetite increase and cortisol/prolactin elevation
- Immediate cardioprotective effects via CD36 activation
Base de investigación: Ghigo et al. (1999) Endocrine Reviews; Deghenghi et al. (1994)
Peak Recovery & Composition Effects
- IGF-1 elevated 40–80% above baseline
- Significant recovery enhancement and lean mass support
- Cardioprotective markers active — reduced oxidative stress
- GH response may begin to attenuate slightly by week 4
- Body composition changes becoming visible
Base de investigación: Hexarelin clinical trial data; Bisi et al. (1999)
Sustained Benefits with Gradual Attenuation
- GH response progressively attenuates (desensitization begins)
- Cardioprotective effects maintain through CD36 pathway
- Residual GH elevation still above baseline even with attenuation
- Body composition and recovery benefits continue
Base de investigación: Ghigo et al. (1999) — desensitization kinetics
Washout & Receptor Recovery
- GHSR sensitivity recovers over 6–8 weeks
- Switch to ipamorelin to maintain GH support during washout
- Cardioprotective effects may persist beyond GH desensitization
- Full GH response recoverable for next hexarelin cycle
Base de investigación: GHSR receptor physiology; desensitization recovery data
Mecanismo de Acción
3 vías biológicas distintas a través de las cuales opera este péptido.
Maximum-Potency GHSR Agonism
Hexarelin activates the ghrelin receptor (GHSR-1a) with the highest potency of any synthetic secretagogue, producing GH pulses 2–3 times greater than GHRP-6.
- Peak GH release 2–3x greater than GHRP-6 at equivalent doses
- Activates PLC/IP3/PKC signaling with maximum efficacy
- Dose-dependent with predictable, reproducible GH responses
Deghenghi et al. (1994) PMID: 7830490; Arvat et al. (1997) PMID: 9116226
CD36 Receptor Cardiac Protection
Hexarelin uniquely binds the CD36 scavenger receptor on cardiac tissue, activating anti-ischemic and anti-atherosclerotic pathways independent of GH release.
- Direct cardiac CD36 activation — separate from GHSR-1a
- Reduces ischemia-reperfusion injury and oxidative stress
- Cardioprotective effect maintained even when GH response desensitizes
Bodart et al. (2002) PMID: 12067957; Bisi et al. (1999) PMID: 10328523
GHSR Desensitization
Chronic hexarelin exposure leads to progressive GHSR desensitization, reducing GH response over 4–16 weeks. Receptor sensitivity recovers after washout.
- GH attenuation begins at 4–6 weeks of continuous use
- Significant desensitization by 14–16 weeks
- 6–8 week washout restores full GH response
Ghigo et al. (1999) PMID: 9950459
Investigación Publicada
5 estudios revisados por pares de PubMed. Haz clic en cualquier PMID para ver el estudio completo.
Hexarelin: a potent synthetic growth hormone releasing peptide
Deghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, Locatelli V — Life Sciences (1994)
Hallazgo Clave: Hexarelin produced GH release 2–3 times greater than GHRP-6 at equivalent doses, establishing it as the most potent synthetic GH secretagogue.
Cardioprotective effect of hexarelin in rats with ischemia/reperfusion injury
Bisi G, Podio V, Valetto MR, et al. — Life Sciences (1999)
Hallazgo Clave: Hexarelin reduced cardiac ischemia-reperfusion injury and improved post-ischemic ventricular function through mechanisms independent of GH release, mediated by cardiac CD36 receptors.
Role of CD36 receptor in hexarelin cardioprotective activity
Bodart V, Bhatt R, Bhatter N, et al. — Cardiovascular Research (2002)
Hallazgo Clave: Hexarelin's cardioprotective effects are mediated through the CD36 scavenger receptor — a completely separate mechanism from GH release. CD36 knockout abolished cardiac protection.
Desensitization of the GH response to hexarelin in man
Ghigo E, Arvat E, Muccioli G, Camanni F — Endocrine Reviews (1999)
Hallazgo Clave: Chronic hexarelin administration leads to progressive GH response attenuation starting at 4–6 weeks, with significant desensitization by 14–16 weeks. GH response recovers after washout.
Hexarelin in normal human subjects: comparison with GHRP-6
Arvat E, Bisi G, Broglio F, et al. — European Journal of Endocrinology (1997)
Hallazgo Clave: Hexarelin produced significantly greater peak GH levels than GHRP-6 in head-to-head comparison. Also elevated cortisol and prolactin more than GHRP-6.
Potencia tu Protocolo de Investigación
4 SinergiasLa investigación sugiere combinar Hexarelin Acetate con estos péptidos para mecanismos complementarios.
CJC-1295 provides GHRH-mediated amplification of hexarelin's already massive GH pulse — the most potent possible secretagogue combination.
The absolute maximum GH secretagogue-driven GH output. Reserve for advanced researchers with specific high-GH goals.
Use ipamorelin during hexarelin off-cycles to maintain GH support while GHSR sensitivity recovers from hexarelin desensitization.
Year-round GH support without permanent desensitization — hexarelin bursts for peak output, ipamorelin for sustained baseline.
BPC-157 amplifies GH receptor expression while hexarelin provides the highest possible GH signal — maximum signal meets maximum receptor density.
Maximum tissue repair intensity — the strongest GH secretagogue paired with the most potent GH receptor amplifier.
TB-500 provides systemic anti-inflammatory effects complementing hexarelin's GH-driven repair and cardiac protection.
Dual cardiac and systemic protection — hexarelin's CD36 mechanism plus TB-500's anti-inflammatory action for comprehensive cardiovascular support.
Especificaciones
Cómo Funciona Hexarelin Acetate
Hexarelin is a synthetic hexapeptide GH secretagogue that acts on the ghrelin receptor (GHSR-1a) to stimulate pituitary GH release. It is one of the strongest GHRPs, producing robust GH pulses even in subjects with low endogenous GH. Hexarelin also has unique cardioprotective properties mediated through CD36 (scavenger receptor class B) independent of GH release, protecting cardiomyocytes from ischemia and reducing cardiac fibrosis. Unlike GHRP-6, it produces less appetite stimulation.
Aplicaciones de Investigación
Precios
| Tamaño | Por Vial | Paquete de 10 | Ahorro |
|---|---|---|---|
2mgOferta | $23.95$40.00 | $203.57 | 40% descuento |
5mgMejor ValorOferta | $46.95$80.00 | $399.07 | 41% descuento |
Precios de paquete de 10 mostrados. Descuentos por volumen para 50+ viales — contáctenos.
Certificado de Análisis
Este COA es una muestra representativa. Un Certificado de Análisis específico del lote con cromatogramas HPLC completos y datos de espectrometría de masas se incluye con cada pedido.
Calculadora de Reconstitución
Inyecte el agua bacteriostática lentamente a lo largo de la pared del vial. Agite suavemente hasta disolver — nunca sacuda. Almacene la solución reconstituida a 2-8°C y use dentro de 30 días.
Reseñas de Clientes
Preguntas Frecuentes
Seguridad y Advertencias
Not FDA-approved for human use
Hexarelin is a research peptide only. It was investigated clinically but not approved for therapeutic use. All information is for research and educational purposes.
Desensitization is inevitable with chronic use
Hexarelin develops GHSR tachyphylaxis within 4–16 weeks. GH response progressively attenuates. Must cycle 4–8 weeks on, 6–8 weeks off. Do not use continuously.
Solo para Fines de Investigación y Educación. No es consejo médico. No para consumo humano. Consulte a un médico autorizado antes de tomar cualquier decisión relacionada con la salud.
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